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We are analyzing https://www.biorxiv.org/content/10.1101/2025.06.11.658946v1.

Title:
Cell type specific CaMKII activation patterns revealed by CaMKAR, a bioactivity reporter deployable in living cells | bioRxiv
Description:
An accurate and precise mechanism for measuring CaMKII activity in living cells is invaluable in the search for effective and targeted CaMKII-based therapeutics. Here, we employ our recently published CaMKII Activity Reporter (CaMKAR) biosensor in order to investigate the spatiotemporal dynamics of CaMKII activation in three different types of cells – cardiac myocytes, skeletal myocytes, and neurons. In doing so, we found a greater rate of CaMKII activation in skeletal muscle compared to cardiac muscle and also delineated CaMKAR’s ability to measure discrete CaMKII activation events in the presence of individual action potentials. By modifying the original CaMKAR sequence, we generated sensors that can be localized to subcellular compartments and thereby preferentially detect the activity of specific spatially-distributed CaMKII isoforms. Finally, we utilized the live-cell data to generate mathematical models of CaMKII activation kinetics, both as an integrated function across multiple calcium transients and as discrete on-off events following individual depolarizations. By furthering our understanding of CaMKII activity profiles across cell types and within subcellular compartments, we hope to support development of CaMKII inhibitors that are optimally precise and potent. ### Competing Interest Statement The authors have declared no competing interest. American Heart Association, 905878
Website Age:
12 years and 2 months (reg. 2013-04-08).

Matching Content Categories {📚}

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Website use Drupal 7 (http://drupal.org).

Traffic Estimate {📈}

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💥 Very Strong Traffic: 200k - 500k visitors per month


Based on our best estimate, this website will receive around 261,717 visitors per month in the current month.

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How Does Biorxiv.org Make Money? {💸}

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Keywords {🔍}

camkii, biology, view, orcid, profile, activation, activity, medrxiv, subject, reviews, clinical, search, preprint, cell, camkar, cells, biorxiv, university, trials, epidemiology, results, specific, reporter, living, pdf, precise, types, cardiac, myocytes, skeletal, muscle, discrete, events, individual, subcellular, compartments, support, competing, interest, authors, declared, information, copyright, institute, technology, cancer, molecular, context, genetics, microbiology,

Topics {✒️}

epidemiology subject categories clinical trials live-cell data targeted camkii-based therapeutics view orcid profile genetics microbiology biorxiv subject category author/funder epidemiology papers cell types health-related information reviews camkii activation kinetics bioactivity reporter deployable measuring camkii activity camkii activity profiles keyword advanced search generate mathematical models multiple calcium transients chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior living cells individual action potentials generous financial support skeletal muscle compared competing interest statement context camkii activation original camkar sequence camkii inhibitors skeletal myocytes cardiac muscle competing interest individual depolarizations support development results follow reyes gaido chi wei hernandez-ochoa precise mechanism spatiotemporal dynamics greater rate generated sensors subcellular compartments preferentially detect integrated function optimally precise

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