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Title:
Telomeric Repeat-Containing RNA Increases in Aged Human Cells | bioRxiv
Description:
Telomeric repeat-containing RNA (TERRA), transcribed from subtelomeric regions towards telomeric ends, poses challenges in deciphering its complete sequences. Utilizing TERRA-capture RNA-seq and Oxford Nanopore direct RNA sequencing to acquire full-length TERRA, we annotate TERRA transcription regions in the human T2T-CHM13 reference genome. TERRA transcripts encompass hundreds to over a thousand nucleotides of telomeric repeats, predominantly originating from 61-29-37 bp repeat promoters enriched with H3K4me3, RNA pol II, CTCF, and R-loops. We develop a bioinformatics tool, TERRA-QUANT, for quantifying TERRA using RNA-seq datasets and find that TERRA increases with age in blood, brain, and fibroblasts. TERRA upregulation in aged leukocytes is confirmed by RT-qPCR. Single-cell RNA-seq analysis demonstrates TERRA expression across various cell types, with upregulation observed in neurons during human embryonic stem cell differentiation. Additionally, TERRA levels are elevated in brain cells in the early stage of Alzheimer’s disease. Our study provides evidence linking TERRA to human aging and diseases. ### Competing Interest Statement The authors have declared no competing interest. National Science and Technology Council, 112-2628-B-002-008, 112-2320-B-002-058, 113-2320-B-002-009, 113-2628-B-002-010-MY3 National Taiwan University, NTU-111L7880, NTU-AS-112L104312, NTU-CDP-112L7721, NTU-CDP-113L7705 National Health Research Institutes, NHRI-EX111-11107SI, NHRI-EX112-11107SI, NHRI-EX113-11107SI, NHRI-EX114-11411SI
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Keywords {🔍}
terra, biology, telomeric, rna, human, national, university, nhriexsi, medrxiv, subject, reviews, clinical, preprint, rnaseq, cell, technology, biorxiv, trials, epidemiology, search, results, repeatcontaining, increases, aged, cells, yeh, pdf, regions, bioinformatics, find, brain, upregulation, competing, interest, authors, declared, information, ntucdpl, health, research, copyright, license, institute, cancer, genomics, context, genetics, microbiology, papers, submitted,
Topics {✒️}
epidemiology subject categories utilizing terra-capture rna-seq clinical trials bioinformatics tool acquire full-length terra nhri-ex114-11411si copyright biorxiv subject category genetics microbiology cell types rna-seq datasets epidemiology papers author/funder health-related information reviews chien-ping yen ntu-cdp-112l7721 yu-chen chen hung-chih kuo preprint telomeric repeat keyword advanced search rna pol ii evidence linking terra nhri-ex111-11107si nhri-ex112-11107si nhri-ex113-11107si chin-hua tai meng-ting yeh po-cheng yang hong-jhih shen chan-hsien yeh der-sheng han generous financial support chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior competing interest statement context human aging aged leukocytes rna increases telomeric ends telomeric repeats brain cells terra-quant quantifying terra terra increases terra upregulation terra levels
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