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Title:
Spatiotemporal mapping of the contractile and adhesive forces sculpting early C. elegans embryos | bioRxiv
Description:
Embryo shape is determined by individual cell mechanics, intercellular interaction strength, and geometrical constraints. Models based on surface tensions at cell interfaces can predict 3D static cellular arrangements within aggregates. However, predicting the dynamics of such arrangements is challenging due to difficulties in measuring temporal changes in tensions. Here, we characterise the spatiotemporal changes in cellular tensions shaping the early nematode embryo using AFM, live microscopy, and tension inference. Using excoriated embryos, we validate a hybrid inference pipeline that calibrates relative inferred tensions temporally using cortical myosin enrichment and absolute tensions using AFM measurements. Applied to embryos within their native shell, we infer a spatiotemporal map of absolute tensions, revealing that ABa, ABp, and EMS compaction is driven by increased tension at free surfaces, while P2
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Keywords {🔍}
biology, tensions, research, preprint, view, orcid, profile, tension, medrxiv, subject, reviews, clinical, spatiotemporal, embryos, cell, council, cancer, biorxiv, university, trials, epidemiology, search, results, early, peer, pdf, embryo, intercellular, cellular, arrangements, due, afm, inference, absolute, contribution, cadherins, competing, interest, authors, declared, information, foundation, european, copyright, license, institute, technology, biophysics, context, genetics,
Topics {✒️}
epidemiology subject categories cell-cell contact tension clinical trials biorxiv subject category individual cell mechanics genetics microbiology epidemiology papers reviews early nematode embryo author/funder peer review [ health-related information keyword advanced search cell interfaces research infrastructure programs fc001086 wellcome trust cellular tensions shaping cortical myosin enrichment generous financial support chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior intercellular interaction strength hybrid inference pipeline p40 od010440 copyright guillaume charras doi competing interest statement context cadherins' indirect contribution preprint spatiotemporal mapping excoriated embryos tension inference competing interest grant agreement surface tensions absolute tensions increased tension high tension intercellular contacts affine contribution copyright holder results follow sacha ichbiah matthieu perez fabrice delbary geometrical constraints models based measuring temporal
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