Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/s41598-018-25665-5.

Title:
Concentration-dependent protein loading of extracellular vesicles released by Histoplasma capsulatum after antibody treatment and its modulatory action upon macrophages | Scientific Reports
Description:
Diverse pathogenic fungi secrete extracellular vesicles (EV) that contain macromolecules, including virulence factors that can modulate the host immune response. We recently demonstrated that the binding of monoclonal antibodies (mAb) modulates how Histoplasma capsulatum load and releases its extracellular vesicles (EV). In the present paper, we addressed a concentration-dependent impact on the fungus’ EV loading and release with different mAb, as well as the pathophysiological role of these EV during the host-pathogen interaction. We found that the mAbs differentially regulate EV content in concentration-dependent and independent manners. Enzymatic assays demonstrated that laccase activity in EV from H. capsulatum opsonized with 6B7 was reduced, but urease activity was not altered. The uptake of H. capsulatum by macrophages pre-treated with EV, presented an antibody concentration-dependent phenotype. The intracellular killing of yeast cells was potently inhibited in macrophages pre-treated with EV from 7B6 (non-protective) mAb-opsonized H. capsulatum and this inhibition was associated with a decrease in the reactive-oxygen species generated by these macrophages. In summary, our findings show that opsonization quantitatively and qualitatively modifies H. capsulatum EV load and secretion leading to distinct effects on the host’s immune effector mechanisms, supporting the hypothesis that EV sorting and secretion are dynamic mechanisms for a fine-tuned response by fungal cells.
Website Age:
30 years and 2 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Education
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🚀🌠 Tremendous Traffic: 10M - 20M visitors per month


Based on our best estimate, this website will receive around 17,585,777 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (9)
google.com, onomagic.com, onlinemediasolutions.com, sparcmedia.com, brightcom.com, audienciad.com, aps.amazon.com, yourbow.com, x.adprime.com

Reseller Advertisers (40)
rubiconproject.com, pubmatic.com, appnexus.com, video.unrulymedia.com, sharethrough.com, google.com, smartadserver.com, onetag.com, openx.com, yahoo.com, triplelift.com, media.net, smaato.com, conversantmedia.com, inmobi.com, themediagrid.com, indexexchange.com, 33across.com, adingo.jp, contextweb.com, axonix.com, outbrain.com, instreamatic.com, omnifytv.com, 152media.info, consumable.com, atasdigital.com, krushmedia.com, rhythmone.com, amxrtb.com, yieldmo.com, adyoulike.com, adform.com, adpone.com, criteo.com, lijit.com, richaudience.com, sovrn.com, improvedigital.com, smilewanted.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$221,600 per month
Our calculations suggest that Nature.com earns between $147,763 and $406,347 monthly online from display advertisements.

Keywords {🔍}

capsulatum, pubmed, article, mab, cells, macrophages, yeast, google, scholar, bev, protein, cas, treatment, bmdm, extracellular, proteins, compared, treated, vesicles, histoplasma, control, fungal, central, antibody, concentration, μgml, intracellular, abundance, cell, nature, mabs, phagocytosis, killing, µgml, performed, data, microbiology, response, activity, infection, nosanchuk, host, fig, analysis, content, pathways, untreated, journal, virulence, independent,

Topics {✒️}

nature portfolio scientific development nature reviews nature proteome research 14 reagents/analytic tools designed research reprints performed research kegg tools trans-cell wall transfer departamento de microbiologia bone marrow-derived macrophages burkholderia pseudomallei-induced cell reactive-oxygen species generated sre1 regulates iron-dependent daniel zamith-miranda & joshua author correspondence original author central carbon metabolism permissions biologically active toxins signaling pathways activated reactive-oxygen species previously published data rio de janeiro pathogenic organisms facilitates full size image media replacement article baltazar th1 cell-mediated immunity daniel zamith-miranda media supplemented concentration-dependent protein loading thermo scientific prados-rosales cross-protective th1 immunity full size table antibody concentration-dependent phenotype obtain permission directly hyungwon choi 100-kda cutoff membrane extracellular vesicles derived fungal cell wall ev protein content supplemental table s1 extracellular vesicles released supplementary figure s2 mab-mediated effects function-enrichment analysis

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Concentration-dependent protein loading of extracellular vesicles released by Histoplasma capsulatum after antibody treatment and its modulatory action upon macrophages
         description:Diverse pathogenic fungi secrete extracellular vesicles (EV) that contain macromolecules, including virulence factors that can modulate the host immune response. We recently demonstrated that the binding of monoclonal antibodies (mAb) modulates how Histoplasma capsulatum load and releases its extracellular vesicles (EV). In the present paper, we addressed a concentration-dependent impact on the fungus’ EV loading and release with different mAb, as well as the pathophysiological role of these EV during the host-pathogen interaction. We found that the mAbs differentially regulate EV content in concentration-dependent and independent manners. Enzymatic assays demonstrated that laccase activity in EV from H. capsulatum opsonized with 6B7 was reduced, but urease activity was not altered. The uptake of H. capsulatum by macrophages pre-treated with EV, presented an antibody concentration-dependent phenotype. The intracellular killing of yeast cells was potently inhibited in macrophages pre-treated with EV from 7B6 (non-protective) mAb-opsonized H. capsulatum and this inhibition was associated with a decrease in the reactive-oxygen species generated by these macrophages. In summary, our findings show that opsonization quantitatively and qualitatively modifies H. capsulatum EV load and secretion leading to distinct effects on the host’s immune effector mechanisms, supporting the hypothesis that EV sorting and secretion are dynamic mechanisms for a fine-tuned response by fungal cells.
         datePublished:2018-05-23T00:00:00Z
         dateModified:2018-05-23T00:00:00Z
         pageStart:1
         pageEnd:10
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41598-018-25665-5
         keywords:
            Fungal biology
            Fungal pathogenesis
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig2_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig3_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig5_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig6_HTML.jpg
         isPartOf:
            name:Scientific Reports
            issn:
               2045-2322
            volumeNumber:8
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ludmila Matos Baltazar
               affiliation:
                     name:Albert Einstein College of Medicine
                     address:
                        name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
                     name:Albert Einstein College of Medicine
                     address:
                        name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
                     name:Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
                     address:
                        name:Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel Zamith-Miranda
               affiliation:
                     name:Albert Einstein College of Medicine
                     address:
                        name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
                     name:Albert Einstein College of Medicine
                     address:
                        name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Meagan C. Burnet
               affiliation:
                     name:Pacific Northwest National Laboratory
                     address:
                        name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hyungwon Choi
               url:http://orcid.org/0000-0002-6687-3088
               affiliation:
                     name:National University of Singapore
                     address:
                        name:Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Leonardo Nimrichter
               affiliation:
                     name:Universidade Federal do Rio de Janeiro (UFRJ)
                     address:
                        name:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ernesto S. Nakayasu
               url:http://orcid.org/0000-0002-4056-2695
               affiliation:
                     name:Pacific Northwest National Laboratory
                     address:
                        name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Joshua D. Nosanchuk
               affiliation:
                     name:Albert Einstein College of Medicine
                     address:
                        name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
                     name:Albert Einstein College of Medicine
                     address:
                        name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Concentration-dependent protein loading of extracellular vesicles released by Histoplasma capsulatum after antibody treatment and its modulatory action upon macrophages
      description:Diverse pathogenic fungi secrete extracellular vesicles (EV) that contain macromolecules, including virulence factors that can modulate the host immune response. We recently demonstrated that the binding of monoclonal antibodies (mAb) modulates how Histoplasma capsulatum load and releases its extracellular vesicles (EV). In the present paper, we addressed a concentration-dependent impact on the fungus’ EV loading and release with different mAb, as well as the pathophysiological role of these EV during the host-pathogen interaction. We found that the mAbs differentially regulate EV content in concentration-dependent and independent manners. Enzymatic assays demonstrated that laccase activity in EV from H. capsulatum opsonized with 6B7 was reduced, but urease activity was not altered. The uptake of H. capsulatum by macrophages pre-treated with EV, presented an antibody concentration-dependent phenotype. The intracellular killing of yeast cells was potently inhibited in macrophages pre-treated with EV from 7B6 (non-protective) mAb-opsonized H. capsulatum and this inhibition was associated with a decrease in the reactive-oxygen species generated by these macrophages. In summary, our findings show that opsonization quantitatively and qualitatively modifies H. capsulatum EV load and secretion leading to distinct effects on the host’s immune effector mechanisms, supporting the hypothesis that EV sorting and secretion are dynamic mechanisms for a fine-tuned response by fungal cells.
      datePublished:2018-05-23T00:00:00Z
      dateModified:2018-05-23T00:00:00Z
      pageStart:1
      pageEnd:10
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41598-018-25665-5
      keywords:
         Fungal biology
         Fungal pathogenesis
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig2_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig3_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig5_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41598-018-25665-5/MediaObjects/41598_2018_25665_Fig6_HTML.jpg
      isPartOf:
         name:Scientific Reports
         issn:
            2045-2322
         volumeNumber:8
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ludmila Matos Baltazar
            affiliation:
                  name:Albert Einstein College of Medicine
                  address:
                     name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
                  name:Albert Einstein College of Medicine
                  address:
                     name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
                  name:Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
                  address:
                     name:Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel Zamith-Miranda
            affiliation:
                  name:Albert Einstein College of Medicine
                  address:
                     name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
                  name:Albert Einstein College of Medicine
                  address:
                     name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Meagan C. Burnet
            affiliation:
                  name:Pacific Northwest National Laboratory
                  address:
                     name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hyungwon Choi
            url:http://orcid.org/0000-0002-6687-3088
            affiliation:
                  name:National University of Singapore
                  address:
                     name:Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Leonardo Nimrichter
            affiliation:
                  name:Universidade Federal do Rio de Janeiro (UFRJ)
                  address:
                     name:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ernesto S. Nakayasu
            url:http://orcid.org/0000-0002-4056-2695
            affiliation:
                  name:Pacific Northwest National Laboratory
                  address:
                     name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Joshua D. Nosanchuk
            affiliation:
                  name:Albert Einstein College of Medicine
                  address:
                     name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
                  name:Albert Einstein College of Medicine
                  address:
                     name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Scientific Reports
      issn:
         2045-2322
      volumeNumber:8
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Albert Einstein College of Medicine
      address:
         name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
      name:Albert Einstein College of Medicine
      address:
         name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
      name:Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
      address:
         name:Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
         type:PostalAddress
      name:Albert Einstein College of Medicine
      address:
         name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
      name:Albert Einstein College of Medicine
      address:
         name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
      name:Pacific Northwest National Laboratory
      address:
         name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
         type:PostalAddress
      name:National University of Singapore
      address:
         name:Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
         type:PostalAddress
      name:Universidade Federal do Rio de Janeiro (UFRJ)
      address:
         name:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
         type:PostalAddress
      name:Pacific Northwest National Laboratory
      address:
         name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
         type:PostalAddress
      name:Albert Einstein College of Medicine
      address:
         name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
      name:Albert Einstein College of Medicine
      address:
         name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ludmila Matos Baltazar
      affiliation:
            name:Albert Einstein College of Medicine
            address:
               name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
            name:Albert Einstein College of Medicine
            address:
               name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
            name:Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais
            address:
               name:Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
               type:PostalAddress
            type:Organization
      name:Daniel Zamith-Miranda
      affiliation:
            name:Albert Einstein College of Medicine
            address:
               name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
            name:Albert Einstein College of Medicine
            address:
               name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
      name:Meagan C. Burnet
      affiliation:
            name:Pacific Northwest National Laboratory
            address:
               name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
               type:PostalAddress
            type:Organization
      name:Hyungwon Choi
      url:http://orcid.org/0000-0002-6687-3088
      affiliation:
            name:National University of Singapore
            address:
               name:Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
               type:PostalAddress
            type:Organization
      name:Leonardo Nimrichter
      affiliation:
            name:Universidade Federal do Rio de Janeiro (UFRJ)
            address:
               name:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
               type:PostalAddress
            type:Organization
      name:Ernesto S. Nakayasu
      url:http://orcid.org/0000-0002-4056-2695
      affiliation:
            name:Pacific Northwest National Laboratory
            address:
               name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
               type:PostalAddress
            type:Organization
      name:Joshua D. Nosanchuk
      affiliation:
            name:Albert Einstein College of Medicine
            address:
               name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
            name:Albert Einstein College of Medicine
            address:
               name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
      name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
      name:Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
      name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
      name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA
      name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
      name:Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore
      name:Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil
      name:Biological Sciences Division, Pacific Northwest National Laboratory, Richland, USA
      name:Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, USA
      name:Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, USA

External Links {🔗}(207)

Analytics and Tracking {📊}

  • Google Analytics
  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

8.13s.