NATURE . COM {}

Matching Content Categories {📚}

• Science
• Education
• Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 21,169,014 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (9)

Reseller Advertisers (40)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

Display Ads ~ $203,300 per month
Our analysis indicates Nature.com generates between $135,514 and $372,663 monthly online from display ads.

Keywords {🔍}

article, google, scholar, cas, nature, mice, japan, insulin, cell, research, crebbp, protein, access, genetics, obesity, science, content, increased, yamauchi, cbp, oike, kamon, transcription, receptors, adipose, development, resistance, author, department, university, tokyo, sensitivity, heterozygous, junji, takashi, kadowaki, binding, biological, nuclear, transcriptional, weight, tissue, open, adipocyte, references, role, biol, proc, sci, mol,

Topics {✒️}

nature portfolio creative scientific research permissions reprints high-fat diet-induced obesity basic helix-loop-helix domain peroxisome proliferator-activated receptor-alpha nature med animal research center insulin-sensitizing hormones secreted nature 405 nature 404 nature 409 nature adipocyte creb/crtc pathway ccaat/enhancer-binding proteins meng-xian li analyzed cbp-deficient mice10 research fellowships author correspondence springerlink instant access research rubinstein-taybi syndrome single amino acid zucker fatty rats increased insulin sensitivity ppar-gamma deficiency yukari date high-fat improved insulin-sensitivity explore content subscription content ppar-alpha activation heterozygous pparγ deficiency white adipose tissue insulin sensitizer acts permissions issue learn retinoid signalling pathway takashi kadowaki crebbp heterozygous mice crebbp null mice nuclear receptor coactivators takeyori saheki binding protein institutional subscriptions read regulated intramembrane proteolysis control mechanism conserved abnormal skeletal patterning dominant-negative mechanism add1/srebp1 controlled

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
         description:The CBP protein (cAMP response element binding protein (CREB) binding protein)1 is a co-activator2 for several transcription factors with a wide range of important biological functions, such as sterol regulatory element binding proteins (SREBPs)3, CCAAT/enhancer-binding proteins (C/EBPs)4, nuclear receptors5,6 (including peroxisome proliferator–activated receptors, PPARs)7, and signal transducers and activators of transcription (STATs)8. In contrast to these individual transcription factors, the biological roles of CBP are poorly understood. CBP enhances transcriptional activities via histone acetylation and the recruitment of additional co-activators such as SRC (steroid coactivator)−1 (ref. 9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice10,11,12. As Crebbp null mice (Crebbp−/−) died during embryogenesis10,11,12, we used Crebbp+/− mice12. Unexpectedly, Crebbp+/− mice showed markedly reduced weight of white adipose tissue (WAT) but not of other tissues. Despite this lipodystrophy, Crebbp+/− mice showed increased insulin sensitivity and glucose tolerance and were completely protected from body weight gain induced by a high-fat (HF) diet. We observed increased leptin sensitivity and increased serum adiponectin levels in Crebbp+/− mice. These increased effects of insulin-sensitizing hormones secreted from WAT may explain, at least in part, the phenotypes of Crebbp+/− mice. This study demonstrates that CBP may function as a 'master-switch' between energy storage and expenditure.
         datePublished:2002-01-30T00:00:00Z
         dateModified:2002-01-30T00:00:00Z
         pageStart:221
         pageEnd:226
         sameAs:https://doi.org/10.1038/ng829
         keywords:
            Biomedicine
            general
            Human Genetics
            Cancer Research
            Agriculture
            Gene Function
            Animal Genetics and Genomics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig5_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig6_HTML.gif
         isPartOf:
            name:Nature Genetics
            issn:
               1546-1718
               1061-4036
            volumeNumber:30
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Toshimasa Yamauchi
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
                     name:CREST of Japan Science and Technology Corporation
                     address:
                        name:CREST of Japan Science and Technology Corporation, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yuichi Oike
               affiliation:
                     name:Institute of Molecular Embryology and Genetics, Kumamoto University
                     address:
                        name:Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Junji Kamon
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
                     name:Biological Research Laboratories, Nissan Chemical Industries
                     address:
                        name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hironori Waki
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
                     name:CREST of Japan Science and Technology Corporation
                     address:
                        name:CREST of Japan Science and Technology Corporation, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kajuro Komeda
               affiliation:
                     name:Animal Research Center, Tokyo Medical University
                     address:
                        name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Atsuko Tsuchida
               affiliation:
                     name:Animal Research Center, Tokyo Medical University
                     address:
                        name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yukari Date
               affiliation:
                     name:Miyazaki Medical College
                     address:
                        name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Meng-Xian Li
               affiliation:
                     name:Faculty of Medicine, Kagoshima University
                     address:
                        name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hiroshi Miki
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yasuo Akanuma
               affiliation:
                     name:CREST of Japan Science and Technology Corporation
                     address:
                        name:CREST of Japan Science and Technology Corporation, Japan
                        type:PostalAddress
                     type:Organization
                     name:Institute for Diabetes Care and Research, Asahi Life Foundation
                     address:
                        name:Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ryozo Nagai
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Satoshi Kimura
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takeyori Saheki
               affiliation:
                     name:Faculty of Medicine, Kagoshima University
                     address:
                        name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Masamitsu Nakazato
               affiliation:
                     name:Miyazaki Medical College
                     address:
                        name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takeshi Naitoh
               affiliation:
                     name:Biological Research Laboratories, Nissan Chemical Industries
                     address:
                        name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kenichi Yamamura
               affiliation:
                     name:Institute of Molecular Embryology and Genetics, Kumamoto University
                     address:
                        name:Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Takashi Kadowaki
               affiliation:
                     name:Graduate School of Medicine, University of Tokyo
                     address:
                        name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                        type:PostalAddress
                     type:Organization
                     name:CREST of Japan Science and Technology Corporation
                     address:
                        name:CREST of Japan Science and Technology Corporation, Japan
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice
      description:The CBP protein (cAMP response element binding protein (CREB) binding protein)1 is a co-activator2 for several transcription factors with a wide range of important biological functions, such as sterol regulatory element binding proteins (SREBPs)3, CCAAT/enhancer-binding proteins (C/EBPs)4, nuclear receptors5,6 (including peroxisome proliferator–activated receptors, PPARs)7, and signal transducers and activators of transcription (STATs)8. In contrast to these individual transcription factors, the biological roles of CBP are poorly understood. CBP enhances transcriptional activities via histone acetylation and the recruitment of additional co-activators such as SRC (steroid coactivator)−1 (ref. 9). To identify its physiological functions using a loss-of-function mutant, we analyzed CBP-deficient mice10,11,12. As Crebbp null mice (Crebbp−/−) died during embryogenesis10,11,12, we used Crebbp+/− mice12. Unexpectedly, Crebbp+/− mice showed markedly reduced weight of white adipose tissue (WAT) but not of other tissues. Despite this lipodystrophy, Crebbp+/− mice showed increased insulin sensitivity and glucose tolerance and were completely protected from body weight gain induced by a high-fat (HF) diet. We observed increased leptin sensitivity and increased serum adiponectin levels in Crebbp+/− mice. These increased effects of insulin-sensitizing hormones secreted from WAT may explain, at least in part, the phenotypes of Crebbp+/− mice. This study demonstrates that CBP may function as a 'master-switch' between energy storage and expenditure.
      datePublished:2002-01-30T00:00:00Z
      dateModified:2002-01-30T00:00:00Z
      pageStart:221
      pageEnd:226
      sameAs:https://doi.org/10.1038/ng829
      keywords:
         Biomedicine
         general
         Human Genetics
         Cancer Research
         Agriculture
         Gene Function
         Animal Genetics and Genomics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig5_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fng829/MediaObjects/41588_2002_Article_BFng829z_Fig6_HTML.gif
      isPartOf:
         name:Nature Genetics
         issn:
            1546-1718
            1061-4036
         volumeNumber:30
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Toshimasa Yamauchi
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
                  name:CREST of Japan Science and Technology Corporation
                  address:
                     name:CREST of Japan Science and Technology Corporation, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yuichi Oike
            affiliation:
                  name:Institute of Molecular Embryology and Genetics, Kumamoto University
                  address:
                     name:Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Junji Kamon
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
                  name:Biological Research Laboratories, Nissan Chemical Industries
                  address:
                     name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hironori Waki
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
                  name:CREST of Japan Science and Technology Corporation
                  address:
                     name:CREST of Japan Science and Technology Corporation, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kajuro Komeda
            affiliation:
                  name:Animal Research Center, Tokyo Medical University
                  address:
                     name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Atsuko Tsuchida
            affiliation:
                  name:Animal Research Center, Tokyo Medical University
                  address:
                     name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yukari Date
            affiliation:
                  name:Miyazaki Medical College
                  address:
                     name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Meng-Xian Li
            affiliation:
                  name:Faculty of Medicine, Kagoshima University
                  address:
                     name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hiroshi Miki
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yasuo Akanuma
            affiliation:
                  name:CREST of Japan Science and Technology Corporation
                  address:
                     name:CREST of Japan Science and Technology Corporation, Japan
                     type:PostalAddress
                  type:Organization
                  name:Institute for Diabetes Care and Research, Asahi Life Foundation
                  address:
                     name:Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ryozo Nagai
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Satoshi Kimura
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takeyori Saheki
            affiliation:
                  name:Faculty of Medicine, Kagoshima University
                  address:
                     name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Masamitsu Nakazato
            affiliation:
                  name:Miyazaki Medical College
                  address:
                     name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takeshi Naitoh
            affiliation:
                  name:Biological Research Laboratories, Nissan Chemical Industries
                  address:
                     name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kenichi Yamamura
            affiliation:
                  name:Institute of Molecular Embryology and Genetics, Kumamoto University
                  address:
                     name:Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Takashi Kadowaki
            affiliation:
                  name:Graduate School of Medicine, University of Tokyo
                  address:
                     name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
                     type:PostalAddress
                  type:Organization
                  name:CREST of Japan Science and Technology Corporation
                  address:
                     name:CREST of Japan Science and Technology Corporation, Japan
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Genetics
      issn:
         1546-1718
         1061-4036
      volumeNumber:30
Organization:
      name:Nature Publishing Group US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:CREST of Japan Science and Technology Corporation
      address:
         name:CREST of Japan Science and Technology Corporation, Japan
         type:PostalAddress
      name:Institute of Molecular Embryology and Genetics, Kumamoto University
      address:
         name:Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:Biological Research Laboratories, Nissan Chemical Industries
      address:
         name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:CREST of Japan Science and Technology Corporation
      address:
         name:CREST of Japan Science and Technology Corporation, Japan
         type:PostalAddress
      name:Animal Research Center, Tokyo Medical University
      address:
         name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
         type:PostalAddress
      name:Animal Research Center, Tokyo Medical University
      address:
         name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
         type:PostalAddress
      name:Miyazaki Medical College
      address:
         name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
         type:PostalAddress
      name:Faculty of Medicine, Kagoshima University
      address:
         name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:CREST of Japan Science and Technology Corporation
      address:
         name:CREST of Japan Science and Technology Corporation, Japan
         type:PostalAddress
      name:Institute for Diabetes Care and Research, Asahi Life Foundation
      address:
         name:Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:Faculty of Medicine, Kagoshima University
      address:
         name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
         type:PostalAddress
      name:Miyazaki Medical College
      address:
         name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
         type:PostalAddress
      name:Biological Research Laboratories, Nissan Chemical Industries
      address:
         name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
         type:PostalAddress
      name:Institute of Molecular Embryology and Genetics, Kumamoto University
      address:
         name:Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
         type:PostalAddress
      name:Graduate School of Medicine, University of Tokyo
      address:
         name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
         type:PostalAddress
      name:CREST of Japan Science and Technology Corporation
      address:
         name:CREST of Japan Science and Technology Corporation, Japan
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Toshimasa Yamauchi
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
            name:CREST of Japan Science and Technology Corporation
            address:
               name:CREST of Japan Science and Technology Corporation, Japan
               type:PostalAddress
            type:Organization
      name:Yuichi Oike
      affiliation:
            name:Institute of Molecular Embryology and Genetics, Kumamoto University
            address:
               name:Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
               type:PostalAddress
            type:Organization
      name:Junji Kamon
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
            name:Biological Research Laboratories, Nissan Chemical Industries
            address:
               name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
               type:PostalAddress
            type:Organization
      name:Hironori Waki
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
            name:CREST of Japan Science and Technology Corporation
            address:
               name:CREST of Japan Science and Technology Corporation, Japan
               type:PostalAddress
            type:Organization
      name:Kajuro Komeda
      affiliation:
            name:Animal Research Center, Tokyo Medical University
            address:
               name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Atsuko Tsuchida
      affiliation:
            name:Animal Research Center, Tokyo Medical University
            address:
               name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Yukari Date
      affiliation:
            name:Miyazaki Medical College
            address:
               name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
               type:PostalAddress
            type:Organization
      name:Meng-Xian Li
      affiliation:
            name:Faculty of Medicine, Kagoshima University
            address:
               name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
               type:PostalAddress
            type:Organization
      name:Hiroshi Miki
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Yasuo Akanuma
      affiliation:
            name:CREST of Japan Science and Technology Corporation
            address:
               name:CREST of Japan Science and Technology Corporation, Japan
               type:PostalAddress
            type:Organization
            name:Institute for Diabetes Care and Research, Asahi Life Foundation
            address:
               name:Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Ryozo Nagai
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Satoshi Kimura
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
      name:Takeyori Saheki
      affiliation:
            name:Faculty of Medicine, Kagoshima University
            address:
               name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
               type:PostalAddress
            type:Organization
      name:Masamitsu Nakazato
      affiliation:
            name:Miyazaki Medical College
            address:
               name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
               type:PostalAddress
            type:Organization
      name:Takeshi Naitoh
      affiliation:
            name:Biological Research Laboratories, Nissan Chemical Industries
            address:
               name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
               type:PostalAddress
            type:Organization
      name:Kenichi Yamamura
      affiliation:
            name:Institute of Molecular Embryology and Genetics, Kumamoto University
            address:
               name:Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
               type:PostalAddress
            type:Organization
      name:Takashi Kadowaki
      affiliation:
            name:Graduate School of Medicine, University of Tokyo
            address:
               name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
               type:PostalAddress
            type:Organization
            name:CREST of Japan Science and Technology Corporation
            address:
               name:CREST of Japan Science and Technology Corporation, Japan
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:CREST of Japan Science and Technology Corporation, Japan
      name:Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:CREST of Japan Science and Technology Corporation, Japan
      name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
      name:Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical University, Tokyo, Japan
      name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
      name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:CREST of Japan Science and Technology Corporation, Japan
      name:Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
      name:Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
      name:Biological Research Laboratories, Nissan Chemical Industries, Saitama, Japan
      name:Department of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
      name:Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
      name:CREST of Japan Science and Technology Corporation, Japan
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/NatureGenet
• https://twitter.com/NatureGenet

External Links {🔗}(106)

• https://link.springer.com/article/10.1038/ng829?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle
• http://scholar.google.com/scholar_lookup?&title=CBP%2Fp300%20in%20cell%20growth%2C%20transformation%2C%20and%20development&journal=Genes%20Dev.&volume=14&pages=1553-1577&publication_year=2000&author=Goodman%2CRH&author=Smolik%2CS
• https://doi.org/10.1016%2FS1054-3589%2808%2960110-6
• http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptor%20coactivators&journal=Adv.%20Pharmacol.&doi=10.1016%2FS1054-3589%2808%2960110-6&volume=47&pages=89-112&publication_year=2000&author=Westin%2CS&author=Rosenfeld%2CMG&author=Glass%2CCK
• https://doi.org/10.1016%2FS0092-8674%2800%2980675-3
• http://scholar.google.com/scholar_lookup?&title=Regulated%20intramembrane%20proteolysis%3A%20a%20control%20mechanism%20conserved%20from%20bacteria%20to%20humans&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980675-3&volume=100&pages=391-398&publication_year=2000&author=Brown%2CMS&author=Ye%2CJ&author=Rawson%2CRB&author=Goldstein%2CJL
• https://doi.org/10.1074%2Fjbc.273.46.30057
• http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20C%2FEBP%20genes%20in%20adipocyte%20differentiation&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.273.46.30057&volume=273&pages=30057-30060&publication_year=1998&author=Darlington%2CGJ&author=Ross%2CSE&author=MacDougald%2COA
• https://doi.org/10.1016%2FS0092-8674%2800%2980498-5
• http://scholar.google.com/scholar_lookup?&title=Nuclear%20receptors%20in%20Sicily%3A%20all%20in%20the%20famiglia&journal=Cell&doi=10.1016%2FS0092-8674%2800%2980498-5&volume=90&pages=391-397&publication_year=1997&author=Perlmann%2CT&author=Evans%2CRM
• https://doi.org/10.1017%2FS0029665199000798
• http://scholar.google.com/scholar_lookup?&title=A%20genetic%20dissection%20of%20the%20retinoid%20signalling%20pathway%20in%20the%20mouse&journal=Proc.%20Nutr.%20Soc.&doi=10.1017%2FS0029665199000798&volume=58&pages=609-613&publication_year=1999&author=Mark%2CM
• https://doi.org/10.1038%2F35013000
• http://scholar.google.com/scholar_lookup?&title=Roles%20of%20PPARs%20in%20health%20and%20disease&journal=Nature&doi=10.1038%2F35013000&volume=405&pages=421-424&publication_year=2000&author=Kersten%2CS&author=Desvergne%2CB&author=Wahli%2CW
• https://doi.org/10.1016%2FS0968-0004%2800%2901624-8
• http://scholar.google.com/scholar_lookup?&title=STAT%20proteins%20and%20transcriptional%20responses%20to%20extracellular%20signals&journal=Trends.%20Biochem.%20Sci.&doi=10.1016%2FS0968-0004%2800%2901624-8&volume=25&pages=496-502&publication_year=2000&author=Horvath%2CCM
• https://doi.org/10.1016%2FS0960-0760%2800%2900112-6
• http://scholar.google.com/scholar_lookup?&title=From%20ligand%20to%20response%3A%20generating%20diversity%20in%20nuclear%20receptor%20coregulator%20function&journal=J.%20Steroid%20Biochem.%20Mol.%20Biol.&doi=10.1016%2FS0960-0760%2800%2900112-6&volume=74&pages=255-259&publication_year=2000&author=McKenna%2CNJ&author=O%27Malley%2CBW
• https://doi.org/10.1073%2Fpnas.94.19.10215
• http://scholar.google.com/scholar_lookup?&title=Abnormal%20skeletal%20patterning%20in%20embryos%20lacking%20a%20single%20Cbp%20allele%3A%20a%20partial%20similarity%20with%20Rubinstein-Taybi%20syndrome&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.94.19.10215&volume=94&pages=10215-10220&publication_year=1997&author=Tanaka%2CY
• https://doi.org/10.1016%2FS0092-8674%2800%2981165-4
• http://scholar.google.com/scholar_lookup?&title=Gene%20dosage-dependent%20embryonic%20development%20and%20proliferation%20defects%20in%20mice%20lacking%20the%20transcriptional%20integrator%20p300&journal=Cell&doi=10.1016%2FS0092-8674%2800%2981165-4&volume=93&pages=361-372&publication_year=1998&author=Yao%2CTP
• https://doi.org/10.1093%2Fhmg%2F8.3.387
• http://scholar.google.com/scholar_lookup?&title=Truncated%20CBP%20protein%20leads%20to%20classical%20Rubinstein-Taybi%20syndrome%20phenotypes%20in%20mice%3A%20implications%20for%20a%20dominant-negative%20mechanism&journal=Hum.%20Mol.%20Genet.&doi=10.1093%2Fhmg%2F8.3.387&volume=8&pages=387-396&publication_year=1999&author=Oike%2CY
• https://doi.org/10.1016%2FS1097-2765%2800%2980210-5
• http://scholar.google.com/scholar_lookup?&title=PPAR%20gamma%20mediates%20high-fat%20diet-induced%20adipocyte%20hypertrophy%20and%20insulin%20resistance&journal=Mol.%20Cell&doi=10.1016%2FS1097-2765%2800%2980210-5&volume=4&pages=597-609&publication_year=1999&author=Kubota%2CN
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=10837022
• http://scholar.google.com/scholar_lookup?&title=Transcriptional%20regulation%20of%20adipogenesis&journal=Genes%20Dev.&volume=14&pages=1293-1307&publication_year=2000&author=Rosen%2CED&author=Walkey%2CCJ&author=Puigserver%2CP&author=Spiegelman%2CBM
• https://doi.org/10.1128%2FMCB.15.5.2582
• http://scholar.google.com/scholar_lookup?&title=Dual%20DNA%20binding%20specificity%20of%20ADD1%2FSREBP1%20controlled%20by%20a%20single%20amino%20acid%20in%20the%20basic%20helix-loop-helix%20domain&journal=Mol.%20Cell.%20Biol.&doi=10.1128%2FMCB.15.5.2582&volume=15&pages=2582-2588&publication_year=1995&author=Kim%2CJB
• https://doi.org/10.1073%2Fpnas.91.15.7355
• http://scholar.google.com/scholar_lookup?&title=Differential%20expression%20and%20activation%20of%20a%20family%20of%20murine%20peroxisome%20proliferator-activated%20receptors&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.91.15.7355&volume=91&pages=7355-7359&publication_year=1994&author=Kliewer%2CSA
• https://doi.org/10.1016%2F0005-2728%2888%2990103-X
• http://scholar.google.com/scholar_lookup?&title=Uncoupling%20protein%20in%20embryonic%20brown%20adipose%20tissue%20existence%20of%20nonthermogenic%20and%20thermogenic%20mitochondria&journal=Biochim.%20Biophys.%20Acta&doi=10.1016%2F0005-2728%2888%2990103-X&volume=935&pages=19-25&publication_year=1988&author=Houstek%2CJ&author=Kopecky%2CJ&author=Rychter%2CZ&author=Soukup%2CT
• http://scholar.google.com/scholar_lookup?&title=Development%20of%20white%20adipose%20tissue&pages=359-378&publication_year=1998&author=Ailaud%2CG&author=Hauner%2CH
• https://doi.org/10.1038%2F35007504
• http://scholar.google.com/scholar_lookup?&title=Obesity%20in%20the%20new%20millennium&journal=Nature&doi=10.1038%2F35007504&volume=404&pages=632-634&publication_year=2000&author=Friedman%2CJM
• https://doi.org/10.1038%2F90984
• http://scholar.google.com/scholar_lookup?&title=Replenishment%20of%20the%20fat-derived%20hormone%20adiponectin%20reverses%20insulin%20resistance%20associated%20with%20both%20lipoatrophy%20and%20obesity&journal=Nature%20Med.&doi=10.1038%2F90984&volume=7&pages=941-946&publication_year=2001&author=Yamauchi%2CT
• https://doi.org/10.1038%2F90992
• http://scholar.google.com/scholar_lookup?&title=The%20adipocyte-secreted%20protein%20Acrp30%20enhances%20hepatic%20insulin%20action&journal=Nature%20Med.&doi=10.1038%2F90992&volume=7&pages=947-953&publication_year=2001&author=Berg%2CAH&author=Combs%2CTP&author=Du%2CX&author=Brownlee%2CM&author=Scherer%2CPE
• https://doi.org/10.1074%2Fjbc.M103241200
• http://scholar.google.com/scholar_lookup?&title=The%20mechanisms%20by%20which%20both%20heterozygous%20PPAR%CE%B3%20deficiency%20and%20PPAR%CE%B3%20agonist%20improve%20insulin%20resistance&journal=J.%20Biol.%20Chem.&doi=10.1074%2Fjbc.M103241200&volume=276&pages=41245-41254&publication_year=2001&author=Yamauchi%2CT
• https://doi.org/10.1172%2FJCI10583
• http://scholar.google.com/scholar_lookup?&title=Cellular%20mechanisms%20of%20insulin%20resistance&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI10583&volume=106&pages=171-176&publication_year=2000&author=Shulman%2CGI
• https://doi.org/10.1046%2Fj.1365-2796.1999.00490.x
• http://scholar.google.com/scholar_lookup?&title=The%20role%20of%20TNFalpha%20and%20TNF%20receptors%20in%20obesity%20and%20insulin%20resistance&journal=J.%20Intern.%20Med.&doi=10.1046%2Fj.1365-2796.1999.00490.x&volume=245&pages=621-625&publication_year=1999&author=Hotamisligil%2CGS
• https://doi.org/10.2337%2Fdiabetes.47.12.1841
• http://scholar.google.com/scholar_lookup?&title=A%20novel%20insulin%20sensitizer%20acts%20as%20a%20coligand%20for%20peroxisome%20proliferator-activated%20receptor-alpha%20%28PPAR-alpha%29%20and%20PPAR-gamma%3A%20effect%20of%20PPAR-alpha%20activation%20on%20abnormal%20lipid%20metabolism%20in%20liver%20of%20Zucker%20fatty%20rats&journal=Diabetes&doi=10.2337%2Fdiabetes.47.12.1841&volume=47&pages=1841-1847&publication_year=1998&author=Murakami%2CK
• https://doi.org/10.1038%2F35007527
• http://scholar.google.com/scholar_lookup?&title=Towards%20a%20molecular%20understanding%20of%20adaptive%20thermogenesis&journal=Nature&doi=10.1038%2F35007527&volume=404&pages=652-660&publication_year=2000&author=Lowell%2CBB&author=Spiegelman%2CBM
• https://doi.org/10.1172%2FJCI8538
• http://scholar.google.com/scholar_lookup?&title=Improved%20insulin-sensitivity%20in%20mice%20heterozygous%20for%20PPAR-gamma%20deficiency&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI8538&volume=105&pages=287-292&publication_year=2000&author=Miles%2CPD&author=Barak%2CY&author=He%2CW&author=Evans%2CRM&author=Olefsky%2CJM
• https://doi.org/10.1073%2Fpnas.98.4.2005
• http://scholar.google.com/scholar_lookup?&title=Proteolytic%20cleavage%20product%20of%2030-kDa%20adipocyte%20complement-related%20protein%20increases%20fatty%20acid%20oxidation%20in%20muscle%20and%20causes%20weight%20loss%20in%20mice&journal=Proc.%20Natl%20Acad.%20Sci.%20USA&doi=10.1073%2Fpnas.98.4.2005&volume=98&pages=2005-2010&publication_year=2001&author=Fruebis%2CJ
• https://doi.org/10.1172%2FJCI7901
• http://scholar.google.com/scholar_lookup?&title=Surgical%20implantation%20of%20adipose%20tissue%20reverses%20diabetes%20in%20lipoatrophic%20mice&journal=J.%20Clin.%20Invest.&doi=10.1172%2FJCI7901&volume=105&pages=271-278&publication_year=2000&author=Gavrilova%2CO
• https://doi.org/10.1038%2F35051587
• http://scholar.google.com/scholar_lookup?&title=A%20role%20for%20ghrelin%20in%20the%20central%20regulation%20of%20feeding&journal=Nature&doi=10.1038%2F35051587&volume=409&pages=194-198&publication_year=2001&author=Nakazato%2CM
• https://citation-needed.springer.com/v2/references/10.1038/ng829?format=refman&flavour=references
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Toshimasa%20Yamauchi
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Toshimasa%20Yamauchi%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yuichi%20Oike
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yuichi%20Oike%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Junji%20Kamon
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Junji%20Kamon%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hironori%20Waki
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hironori%20Waki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kajuro%20Komeda
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kajuro%20Komeda%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Atsuko%20Tsuchida
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Atsuko%20Tsuchida%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yukari%20Date
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yukari%20Date%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Meng-Xian%20Li
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Meng-Xian%20Li%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Hiroshi%20Miki
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Hiroshi%20Miki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Yasuo%20Akanuma
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Yasuo%20Akanuma%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Ryozo%20Nagai
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Ryozo%20Nagai%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Satoshi%20Kimura
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Satoshi%20Kimura%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takeyori%20Saheki
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takeyori%20Saheki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Masamitsu%20Nakazato
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Masamitsu%20Nakazato%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takeshi%20Naitoh
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takeshi%20Naitoh%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kenichi%20Yamamura
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kenichi%20Yamamura%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Takashi%20Kadowaki
• http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Takashi%20Kadowaki%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en
• https://static-content.springer.com/esm/art%3A10.1038%2Fng829/MediaObjects/41588_2002_BFng829z_MOESM1_ESM.pdf
• https://s100.copyright.com/AppDispatchServlet?title=Increased%20insulin%20sensitivity%20despite%20lipodystrophy%20in%20Crebbp%20heterozygous%20mice&author=Toshimasa%20Yamauchi%20et%20al&contentID=10.1038%2Fng829©right=Springer%20Nature%20America%2C%20Inc.&publication=1061-4036&publicationDate=2002-01-30&publisherName=SpringerNature&orderBeanReset=true
• https://citation-needed.springer.com/v2/references/10.1038/ng829?format=refman&flavour=citation
• https://doi.org/10.1038/s41419-020-02960-6
• https://doi.org/10.1038/nrendo.2015.181
• https://doi.org/10.1007/s10565-016-9318-0
• https://doi.org/10.1007/s13238-015-0204-y
• https://doi.org/10.1038/jhg.2013.57
• https://www.protocols.io/
• https://www.natureindex.com/
• http://www.naturechina.com
• https://www.natureasia.com/ja-jp

Analytics and Tracking {📊}

• Google Analytics
• Google Tag Manager

Javascript Libraries {📚}

• Prism.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk