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Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? | Cell Death & Differentiation
Description:
Unicellular organisms, such as the protozoan parasite Leishmania, can be stimulated to show some morphological and biochemical features characteristic of mammalian apoptosis. This study demonstrates that under a variety of stress conditions such as serum deprivation, heat shock and nitric oxide, cell death can be induced leading to genomic DNA fragmentation into oligonucleosomes. DNA fragmentation was observed, without induction, in the infectious stages of the parasite, and correlated with the presence of internucleosomal nuclease activity, visualisation of 45 to 59 kDa nucleases and detection of TUNEL-positive nuclei. DNA fragmentation was not dependent on active effector downstream caspases nor on the lysosomal cathepsin L-like enyzmes CPA and CPB. These data are consistent with the presence of a caspase-independent cell death mechanism in Leishmania, induced by stress and differentiation that differs significantly from metazoa.
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Keywords {🔍}
cell, death, activity, dna, figure, pubmed, article, google, scholar, leishmania, cas, nuclei, fragmentation, parasites, lane, nuclease, phase, promastigotes, observed, caspase, mexicana, amastigote, apoptosis, presence, shown, cells, amastigotes, major, nuclear, degradation, mnase, addition, apoptotic, differentiation, parasite, data, programmed, mouse, cysteine, devdase, incubated, pcd, chromatin, stationary, logarithmic, nucleases, axenics, days, min, assay,
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nature portfolio permissions reprints mexicana mnyc/bz/62/m379 wild-type nature author information authors cysteine proteinase-deficient mutants caspase-3-7 substrate ac-devd-amc unique c-terminal extension host-parasite interactions curr author correspondence culture media sds–dna–page system sds–dna–page technique 30 μm ac-devd-amc full size image δcpa/cpb mutant39 promastigotes cpb null mutants post-mortem event due access ca2+-specific chelator egta welburn sc caspase inhibitor z-vad tunel-positive parasite nuclei endogenous site-unspecific endonuclease mouse lesion isolated-amastigotes mouse lesion-isolated amastigotes media 1 mg/ml ethidium bromide trypanosoma brucei rhodesiense elongation factor 1-alpha cysteine proteinase mol leishmania donovani promastigotes cell death differ unicellular organism leishmania explore content development tunel-positive amastigote nuclei lysosomal cysteine proteases recombinant cysteine proteinase brucei procyclic forms glass slides covered transmission electron microscopy olie ra belli si similar content wild-type axenics appeared human parasite leishmania short heat-shock treatment activated protein kinase sds–dna–page
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- 1996 A new twist to the tale?
- Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?
- Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?
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