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Title:
Targeting key angiogenic pathways with a bispecific CrossMAb optimized for neovascular eye diseases - PubMed
Description:
Anti-angiogenic therapies using biological molecules that neutralize vascular endothelial growth factor-A (VEGF-A) have revolutionized treatment of retinal vascular diseases including age-related macular degeneration (AMD). This study reports preclinical assessment of a strategy to enhance anti-VEGF …
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Keywords {🔍}
doi, pmid, pmc, pubmed, neovascular, diseases, free, article, vascular, vegfa, macular, angiopoietin, bispecific, eye, targeting, endothelial, growth, agerelated, degeneration, efficacy, factor, figure, mol, crossmab, klein, ang, inhibition, model, monoclonal, antibodies, articles, information, med, emmm, regula, stubenrauch, treatment, retinal, antibody, therapy, dual, aug, review, faricimab, ophthalmol, immunologic, factors, main, ncbi, figures,
Topics {✒️}
main page content age‐related macular degeneration age-related macular degeneration neovascular eye diseases neovascular eye diseases retinal vascular diseases health animal drug evaluation literature sources spontaneous choroidal neovascularization neovascular ocular diseases retinal vascular disease articles references aguilar similar articles ang-2-vegf factor strongly upregulated generation therapy literature review diabetic macular oedema similar articles cited pubmed central embo mol med lundh von leithner chui ming gc gemmy cheung cm diabetic macular edema bo tun sb tetravalent bispecific antibody bispecific domain-exchanged united states government hoffmann‐la roche ang-2 functions simultaneously mediates potent antitumor investigate subretinal fibrosis enhance anti-vegf anti-metastatic efficacy tie2 receptor ligands tie2 receptor ectodomain clin cancer res angiopoietin‐tie system angiopoietin‐2‐tie2 complex bispecific crossmab optimized yeo sia wey 4 properties make rg7716 eye curr opin ophthalmol 201505889 erratum monoclonal antibody vascular morphogenesis dual pathway inhibition anti-angiogenic
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