
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines - PMC
Description:
Airway remodeling and dysfunction are characteristic features of asthma thought to be caused by aberrant production of Th2 cytokines. Histamine H4 receptor (H4R) perturbation has previously been shown to modify acute inflammation and Th2 cytokine ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
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Keywords {🔍}
doi, airway, lung, inflammation, treatment, animals, asthma, cell, cells, pubmed, google, scholar, antiil, antagonist, model, vehicle, levels, allergic, tissue, mice, treated, histamine, jnj, mgkg, antagonism, production, cytokine, effect, ccl, cytokines, hyperreactivity, fig, receptor, remodeling, reduction, measured, lungs, antagonists, collagen, challenge, study, group, antibody, data, significantly, free, compared, control, pmc, previously,
Topics {✒️}
competing interests specific pathogen-free conditions t-cell-mediated respiratory inflammation compare drug-treated groups ova-specific ige levels pmc beta search enzyme-llinked immunosorbent assays antigen-specific ige observed serum ova-specific ige draining lymph node anti-mouse il-13 mab double-blind randomised study positive end-expiratory pressure anti-il-13 treated groups anti-il-13 antibody made supplementary materials included anti-il-13 significantly inhibited allergen-induced airway hyperreactivity ova-stimulated culture supernatants rat anti-mouse il-13 control vehicle-treated animals anti-il-13 antibody failed cells/field versus h4r license information pmcid anti-il-13 treated animals antigen-specific th2 cells histamine h4 receptor alcian blue/pas stain anti-il-13 treatment resulted antigen-challenged allergic mice anti-il-13 antibody treatment ova-free diet ongoing ige-mediated free collagen levels total free collagen bronchoalveolar lavage fluid h4r antagonist inhibits jing ying ma references bousquet tavares-de-lima antigen specific stimulation cd3+ primary antibody normal goat igg th2-type cytokines identified primary biogenic amine rev respir dis 35 versus anti-il-13 inhibits allergic asthma publisher site pdf il-13 driven pathologies
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