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We are analyzing https://www.tandfonline.com/doi/full/10.1128/mcb.20.9.3198-3209.2000.

Title:
Protein Zero Gene Expression Is Regulated by the Glial Transcription Factor Sox10: Molecular and Cellular Biology: Vol 20 , No 9 - Get Access
Description:
The nervous system contains two major types of cells, neurons and glia. The task of glial cells is to support development, survival, and functionality of neurons. Glial cells are found associated w...
Website Age:
19 years and 10 months (reg. 2005-08-30).

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🌠 Phenomenal Traffic: 5M - 10M visitors per month

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$42,000 per month
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Keywords {🔍}

access, journals, sciences, open, taylor, francis, search, article, sox, online, journal, studies, browse, log, find, environment, science, gene, articles, group, page, publish, health, social, cart, issue, pdf, technology, information, register, protein, expression, transcription, molekulare, neurobiologie, universität, hamburg, dhamburg, read, myelin, content, close, menu, select, calls, papers, suggester, publishing, guidance, author,

Topics {✒️}

social care medicine journals bioscience molecular downloaded article pdf twitter page taylor article /doi/full/10 francis group high-affinity sites journal search calls cart search glial transcription factor downloaded article pdfs advanced search molecular limited period read lists articles find guidance institution access published online distal region functioned journals books receive personalised research crossref citations distal promoter region citing articles based journals browse wild-type sox10 author services home cellular biology list schwann cell lineage peripheral nervous system detailed analyses revealed schwann cell precursors n2a neuroblastoma expressing applicable share back issue 9 protein open cell-specific activation information journals a myelin gene expression article https date register sox proteins register log crossref icon sox10 mutants sox10 mutation myelin gene transcription factors taylor myelin sheath

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            name:Volume 20, Issue 9
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            name:Protein Zero Gene Expression Is Regulate ....
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PublicationIssue:
      id:#issue
      issueNumber:9
      datePublished:2000-05-01
      isPartOf:
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         type:
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         name:Molecular and Cellular Biology
         issn:
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      name:Molecular and Cellular Biology
      issn:
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      publisher:Taylor & Francis Group
ScholarlyArticle:
      mainEntityOfPage:https://www.tandfonline.com/doi/full/10.1128/MCB.20.9.3198-3209.2000
      url:https://www.tandfonline.com/doi/full/10.1128/MCB.20.9.3198-3209.2000
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      articleSection:Transcriptional Regulation
      name:Protein Zero Gene Expression Is Regulated by the Glial Transcription Factor Sox10
      headline:Protein Zero Gene Expression Is Regulated by the Glial Transcription Factor Sox10
      abstract:Myelinating glia express high levels of a unique set of genes which code for structural proteins of the myelin sheath. Few transcription factors have so far been implicated in the regulation of any myelin gene. Here we show that the protein zero (P0) gene, a myelin gene exclusively expressed in the Schwann cell lineage of the peripheral nervous system, is controlled in its expression by the high-mobility-group domain protein Sox10 both in tissue culture and in vivo. Induction of wild-type Sox10, but not of other transcription factors or Sox10 mutants, strongly increased endogenous P0expression in tissue culture. This activation was mediated by the P0 promoter, which was stimulated by Sox10 in transient transfections. Detailed analyses revealed the involvement of a proximal and a distal promoter region. The distal region functioned only in conjunction with the proximal one and contained a single Sox consensus binding site, which accounted for most of its activity. In contrast, the proximal region mediated Sox10 responsiveness on its own. It contained multiple binding sites for Sox proteins, with two high-affinity sites being the most significant. P0expression also depended on Sox10 in vivo, as evident from the analysis of Schwann cell precursors in mouse embryos with Sox10 mutation at day 12.5 of embryogenesis. To our knowledge this is the most conclusive link to date between a glial transcription factor and cell-specific activation of myelin gene expression.
      description:Myelinating glia express high levels of a unique set of genes which code for structural proteins of the myelin sheath. Few transcription factors have so far been implicated in the regulation of any myelin gene. Here we show that the protein zero (P0) gene, a myelin gene exclusively expressed in the Schwann cell lineage of the peripheral nervous system, is controlled in its expression by the high-mobility-group domain protein Sox10 both in tissue culture and in vivo. Induction of wild-type Sox10, but not of other transcription factors or Sox10 mutants, strongly increased endogenous P0expression in tissue culture. This activation was mediated by the P0 promoter, which was stimulated by Sox10 in transient transfections. Detailed analyses revealed the involvement of a proximal and a distal promoter region. The distal region functioned only in conjunction with the proximal one and contained a single Sox consensus binding site, which accounted for most of its activity. In contrast, the proximal region mediated Sox10 responsiveness on its own. It contained multiple binding sites for Sox proteins, with two high-affinity sites being the most significant. P0expression also depended on Sox10 in vivo, as evident from the analysis of Schwann cell precursors in mouse embryos with Sox10 mutation at day 12.5 of embryogenesis. To our knowledge this is the most conclusive link to date between a glial transcription factor and cell-specific activation of myelin gene expression.
      author:
            type:Person
            name:Reto I. Peirano
            type:Person
            name:Derk E. Goerich
            type:Person
            name:Dieter Riethmacher
            type:Person
            name:Michael Wegner
      pageStart:3198
      pageEnd:3209
      datePublished:2023-03-27
      publisher:
         type:Organization
         name:Taylor & Francis
         logo:
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Person:
      name:Reto I. Peirano
      name:Derk E. Goerich
      name:Dieter Riethmacher
      name:Michael Wegner
Organization:
      name:Taylor & Francis
      logo:
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ImageObject:
      url:https://www.tandfonline.com/pb-assets/Images/Taylor_and_Francis_Group_Logo-1742461082.png

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