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data, pubmed, cells, article, min, glucose, source, wdr, google, scholar, cas, analysis, mtorc, amino, fig, nature, cell, acids, wcls, extended, central, hek, derived, restimulated, ampk, deprived, constructs, ips, western, blots, knockin, unprocessed, mice, metabolism, phosphorylation, gator, access, scale, bar, representative, signalling, wdrsd, nat, hela, image, shown, reconstituted, antiflag, fasted, activation,

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crispr-cas9-mediated genome editing integrative cancer research nature portfolio journals privacy policy nature portfolio glyceraldehyde-3-phosphate dehydrogenase-mediated regulation nature metabolism team advertising mtorc1-regulated substrates william embryonic development social media reprints sun yat-sen university fine-tune mtorc1 activation generated wdr24-ps155 antibody a1/b1/g2 subunits anti-thiophosphate-ester antibody amp-activated protein kinase nutrient-sensing hub gator2 wdr24-ps155 antibody recognizes publishing agreement anti-flag ips derived targeting ampk–wdr24 signalling anti-ha ips derived anti-wdr24 ips derived full-length human ampk phospho-deficient wdr24s155a knock nature+ nature 596 nature 493 nature 543 nature 556 nature 607 nature 548 nature extended data fig tumor suppressor complex energy stress conditions accepted manuscript version permissions source data fig springerlink instant access glycolytic flux signals cell death discov content ampk knocks gator1–rag gtpases complexes wdr24-s155d mutation combat human diseases haihong yu & ping wang regulate mtorc1 signalling

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• How does mTOR sense glucose starvation?

Schema {🗺️}

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      name:Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, School of Life Sciences and Technology, Tongji University, Shanghai, China
      name:Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, School of Life Sciences and Technology, Tongji University, Shanghai, China
      name:Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:The David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
      name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
      name:Division of Signal Transduction, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, USA
      name:Tongji University Cancer Center, Shanghai Tenth People’s Hospital, School of Medicine, School of Life Sciences and Technology, Tongji University, Shanghai, China
      name:Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
      name:Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA
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