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We are analyzing https://www.nature.com/articles/s42255-021-00479-4.

Title:
Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication | Nature Metabolism
Description:
Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to severe multi-organ damage and death. Here we show that cellular lipid synthesis is required for SARS-CoV-2 replication and offers an opportunity for pharmacological intervention. Screening a short-hairpin RNA sublibrary that targets metabolic genes, we identified genes that either inhibit or promote SARS-CoV-2 viral infection, including two key candidate genes, ACACA and FASN, which operate in the same lipid synthesis pathway. We further screened and identified several potent inhibitors of fatty acid synthase (encoded by FASN), including the US Food and Drug Administration-approved anti-obesity drug orlistat, and found that it inhibits in vitro replication of SARS-CoV-2 variants, including more contagious new variants, such as Delta. In a mouse model of SARS-CoV-2 infection (K18-hACE2 transgenic mice), injections of orlistat resulted in lower SARS-CoV-2 viral levels in the lung, reduced lung pathology and increased mouse survival. Our findings identify fatty acid synthase inhibitors as drug candidates for the prevention and treatment of COVID-19 by inhibiting SARS-CoV-2 replication. Clinical trials are needed to evaluate the efficacy of repurposing fatty acid synthase inhibitors for severe COVID-19 in humans. Pharmacological inhibitors of fatty acid synthase, including the approved anti-obesity drug orlistat, are shown to inhibit replication of SARS-CoV-2 in vitro and in a mouse model of infection in vivo.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
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Content Management System {📝}

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Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

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What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

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The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
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How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
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Keywords {🔍}

sarscov, cells, infection, data, viral, inhibitors, orlistat, fas, fig, cell, tvb, article, infected, virus, hekthace, google, scholar, cas, replication, rna, mice, assay, acid, source, performed, nature, treatment, fasn, analysis, covid, extended, control, mouse, fluorescence, day, medium, fatty, variants, lung, host, moi, statistical, qpcr, experiments, metabolism, inhibit, sarscovmng, activity, analyzed, added,

Topics {✒️}

nature portfolio permissions reprints privacy policy research design editing advertising mantel–cox log-rank test mantel-cox log-rank test rong-fu wang vivo anti-sars-cov-2 activity sars-cov-2 main protease vivo anti-sars-cov-2 infection free fatty acids social media south africa inhibit sars-cov-2-mng infection sars-cov-2-induced lethal inflammation protected sars-cov-2-infected mice nature https fda-approved anti-obesity drug potential anti-sars-cov-2 drugs drug development markedly inhibited sars-cov-2 sars-cov-2 virus-infected mice bsa-conjugated palmitic acid india sars-cov-2 spike protein sars-cov-2-infected mice treated treated sars-cov-2-infected mice suppress sars-cov-2 replication screening shrna library anti-fas monoclonal antibody potently inhibit sars-cov-2 anti-sars-cov-2 activity strikingly inhibit sars-cov-2 sars-cov-2-mng viruses32 nature 584 nature 582 nature 586 nature akt/mtor/hif-1α vaccine-induced antibody neutralization40 sars-cov-2-mng virus severe multi-organ damage pan-flavivirus host factor specific-pathogen-free facilities gpr40-mediated dual pathways akt/nf-κb pathways sars-cov-2-mng viruses anti-sars-cov-2 ability

Schema {🗺️}

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      affiliation:
            name:University of Southern California
            address:
               name:The Hastings and Wright Laboratories, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Xin Liu
      url:http://orcid.org/0000-0001-7949-1436
      affiliation:
            name:University of Southern California
            address:
               name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Chen Qian
      affiliation:
            name:University of Southern California
            address:
               name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Bingnan Yin
      affiliation:
            name:University of Southern California
            address:
               name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Helen Yicheng Wang
      affiliation:
            name:University of Southern California
            address:
               name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:University of Southern California
            address:
               name:Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      name:Rong-Fu Wang
      url:http://orcid.org/0000-0002-8834-2763
      affiliation:
            name:University of Southern California
            address:
               name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:University of Southern California
            address:
               name:Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
            name:University of Southern California
            address:
               name:Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, USA
      name:The Hastings and Wright Laboratories, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Department of Pediatrics, Children’s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, USA
      name:Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA

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