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We are analyzing https://www.nature.com/articles/s41590-018-0200-5.

Title:
An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells | Nature Immunology
Description:
Different types of effector and memory T lymphocytes are induced and maintained in protective or pathological immune responses. Here we characterized two human CD4+ TH17 helper cell subsets that, in the recently activated state, could be distinguished on the basis of their expression of the anti-inflammatory cytokine IL-10. IL-10+ TH17 cells upregulated a variety of genes encoding immunoregulatory molecules, as well as genes whose expression is characteristic of tissue-resident T cells. In contrast, IL-10– TH17 cells maintained a pro-inflammatory gene-expression profile and upregulated the expression of homing receptors that guide recirculation from tissues to blood. Expression of the transcription factor c-MAF was selectively upregulated in IL-10+ TH17 cells, and it was bound to a large set of enhancer-like regions and modulated the immunoregulatory and tissue-residency program. Our results identify c-MAF as a relevant factor that drives two highly divergent post-activation fates of human TH17 cells and provide a framework with which to investigate the role of these cells in physiology and immunopathology. TH17 cells contribute to anti-fungal and anti-bacterial adaptive immune responses. Sallusto and colleagues show that the transcription factor c-Maf has an immunoregulatory role in directing gene expression and tissue residency in human IL-10+ TH17 cell subsets.
Website Age:
30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

article, google, scholar, cells, cas, thil, nature, expression, cell, cmaf, nat, immunol, human, gene, data, day, memory, activated, supplementary, genes, analysis, access, regulatory, immune, enrichment, transcription, experiments, figure, disease, cytokine, isoform, content, regions, rev, immunity, receptor, ccr, research, manuscript, shown, hkac, peaks, cookies, function, information, sallusto, effector, lymphocytes, inflammation, production,

Topics {✒️}

permissions reprints nature portfolio journals privacy policy nature portfolio cd103+cd8+ tissue-resident memory subset-specific h3k27ac-positive regions advertising th17-il-10–-specific h3k27ac domains european research council cell type-specific enhancers recently-activated th17-il-10+-specific social media plate-bound cd3/cd28 antibodies large-scale chip-seq analysis pro-inflammatory gene-expression profile high-throughput chromatin immunoprecipitation subset-specific h3k27ac peaks development vivo protein-dna interactions pre-existent enhancer landscape research h3k27ac chip-seq data c-maf binding profiles c-maf peak localized functional cytokine memory c-maf-dependent regulatory tissue-resident memory transcription factor c-maf il-10-producing tr1 cells results identify c-maf article initially published expressing th17-il10– cells �dna motif–enrichment analysis c-maf binding sites tissue-residency genes loci th17-mediated autoimmune diseases establishing functional microenvironments c-maf-dependent genes th17 cells promotes rna-seq data tissue-residency program modulated springerlink instant access high-resolution transcriptome c-maf-bound regions nature+ nature 401 nature 484 nature 528 nature 498 nature 459

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            address:
               name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
               type:PostalAddress
            type:Organization
      name:Samuele Notarbartolo
      url:http://orcid.org/0000-0001-5910-4910
      affiliation:
            name:Università della Svizzera italiana
            address:
               name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Federica Sallusto
      url:http://orcid.org/0000-0003-3750-2752
      affiliation:
            name:Università della Svizzera italiana
            address:
               name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
               type:PostalAddress
            type:Organization
            name:ETH Zurich
            address:
               name:Institute of Microbiology, ETH Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Translational Gastroenterology Unit, NDM Experimental Medicine, University of Oxford, Oxford, UK
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Swiss Institute of Bioinformatics, Lausanne, Switzerland
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Ann Romney Center for Neurologic Diseases and Evergrande Center for Immunologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana, Bellinzona, Switzerland
      name:Institute of Microbiology, ETH Zurich, Zurich, Switzerland
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