
NATURE . COM {
}
Title:
Extended Data Fig. 4: MICL regulates NET formation. | Nature
Description:
No description found...
Website Age:
30 years and 10 months (reg. 1994-08-11).
Matching Content Categories {📚}
- Social Networks
- Telecommunications
- Virtual Reality
Content Management System {📝}
What CMS is nature.com built with?
Custom-built
No common CMS systems were detected on Nature.com, and no known web development framework was identified.
Traffic Estimate {📈}
What is the average monthly size of nature.com audience?
🌆 Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Nature.com Make Money? {💸}
Display Ads {🎯}
The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.
Ads are managed by yourbow.com. Particular relationships are as follows:
Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.comReseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.comHow Much Does Nature.com Make? {💰}
Display Ads {🎯}
$531,700 per month
Our estimates place Nature.com's monthly online earnings from display ads at $354,480 to $974,820.
Keywords {🔍}
nature, data, nets, cookies, green, privacy, content, sytox, neutrophils, representative, performed, advertising, micl, net, thioglycollateelicited, experiments, triplicate, images, msuinduced, isolated, cells, quantification, statistical, significance, determined, students, ttest, dnah, research, optional, media, personal, parties, area, policy, information, journals, articles, article, extended, fig, formation, fluorescence, netbound, analysed, independent, fluorescent, bright, field, micldeficient,
Topics {✒️}
nature portfolio privacy policy nature advertising extended data fig social media cit-h3/gr-1 area thioglycollate-elicited neutrophils analysed thioglycollate-elicited neutrophils isolated net-bound sytox green explore content thioglycollate-elicited neutrophils net-bound sytox privacy personal data european economic area journals search log spark cyto reader statistical significance determined dpi pre-treatment data protection pooled data pma-induced nets accepting optional cookies content micl-deficient animals micl−/− synovial sections msu-induced nets manage preferences bright field images cit-h3 dna/h1 independent experiments performed net positive data neutrophils isolated stained unfixed optional cookies choices articles essential cookies cookies skip bright field net negative = 3 independent experiments cells = 2 experiments performed usage analysis varying standards journal publish
Schema {🗺️}
WebPage:
mainEntity:
headline:Recognition and control of neutrophil extracellular trap formation by MICL
description:Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if this process is uncontrolled, NETs contribute to disease pathogenesis, exacerbating inflammation and host tissue damage1,2. Here we show that myeloid inhibitory C-type lectin-like (MICL), an inhibitory C-type lectin receptor, directly recognizes DNA in NETs; this interaction is vital to regulate neutrophil activation. Loss or inhibition of MICL functionality leads to uncontrolled NET formation through the ROSâPAD4 pathway and the development of an auto-inflammatory feedback loop. We show that in the context of rheumatoid arthritis, such dysregulation leads to exacerbated pathology in both mouse models and in human patients, where autoantibodies to MICL inhibit key functions of this receptor. Of note, we also detect similarly inhibitory anti-MICL autoantibodies in patients with other diseases linked to aberrant NET formation, including lupus and severe COVID-19. By contrast, dysregulation of NET release is protective during systemic infection with the fungal pathogen Aspergillus fumigatus. Together, we show that the recognition of NETs by MICL represents a fundamental autoregulatory pathway that controls neutrophil activity and NET formation. How MICL recognizes and autoregulates the formation of neutrophil extracellular traps is explored in mouse models and human patients where disease severity is associated with aberrant neutrophil extracellular trap formation.
datePublished:2024-08-14T00:00:00Z
dateModified:2024-08-14T00:00:00Z
pageStart:442
pageEnd:450
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41586-024-07820-3
keywords:
Cell biology
Immunology
Infectious diseases
Rheumatic diseases
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig5_HTML.png
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:633
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Mariano Malamud
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Lauren Whitehead
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Alasdair McIntosh
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Fabio Colella
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Anke J. Roelofs
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Takato Kusakabe
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
type:Person
name:Ivy M. Dambuza
url:http://orcid.org/0000-0001-6556-6476
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Annie Phillips-Brookes
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Fabián Salazar
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Federico Perez
affiliation:
name:Hospital for Sick Children
address:
name:Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Romey Shoesmith
url:http://orcid.org/0000-0001-6629-6172
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Przemyslaw Zakrzewski
url:http://orcid.org/0000-0003-0035-5509
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
type:Person
name:Emily A. Sey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Cecilia Rodrigues
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Petruta L. Morvay
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Pierre Redelinghuys
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Tina Bedekovic
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Maria J. G. Fernandes
affiliation:
name:Laval University
address:
name:Faculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Canada
type:PostalAddress
type:Organization
type:Person
name:Ruqayyah Almizraq
url:http://orcid.org/0000-0001-8494-6538
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Donald R. Branch
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Borko Amulic
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
type:Person
name:Jamie Harvey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Diane Stewart
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Raif Yuecel
affiliation:
name:University of Exeter
address:
name:Centre for Cytomics, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Delyth M. Reid
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Alex McConnachie
url:http://orcid.org/0000-0002-7262-7000
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Matthew C. Pickering
url:http://orcid.org/0000-0002-1153-0192
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
type:Person
name:Marina Botto
url:http://orcid.org/0000-0002-1458-3791
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
type:Person
name:Iliyan D. Iliev
url:http://orcid.org/0000-0003-0884-9749
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
type:Person
name:Iain B. McInnes
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Cosimo De Bari
url:http://orcid.org/0000-0002-5113-862X
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Janet A. Willment
url:http://orcid.org/0000-0002-7040-0857
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Gordon D. Brown
url:http://orcid.org/0000-0002-0287-5383
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
type:ScholarlyArticle
context:https://schema.org
ScholarlyArticle:
headline:Recognition and control of neutrophil extracellular trap formation by MICL
description:Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if this process is uncontrolled, NETs contribute to disease pathogenesis, exacerbating inflammation and host tissue damage1,2. Here we show that myeloid inhibitory C-type lectin-like (MICL), an inhibitory C-type lectin receptor, directly recognizes DNA in NETs; this interaction is vital to regulate neutrophil activation. Loss or inhibition of MICL functionality leads to uncontrolled NET formation through the ROSâPAD4 pathway and the development of an auto-inflammatory feedback loop. We show that in the context of rheumatoid arthritis, such dysregulation leads to exacerbated pathology in both mouse models and in human patients, where autoantibodies to MICL inhibit key functions of this receptor. Of note, we also detect similarly inhibitory anti-MICL autoantibodies in patients with other diseases linked to aberrant NET formation, including lupus and severe COVID-19. By contrast, dysregulation of NET release is protective during systemic infection with the fungal pathogen Aspergillus fumigatus. Together, we show that the recognition of NETs by MICL represents a fundamental autoregulatory pathway that controls neutrophil activity and NET formation. How MICL recognizes and autoregulates the formation of neutrophil extracellular traps is explored in mouse models and human patients where disease severity is associated with aberrant neutrophil extracellular trap formation.
datePublished:2024-08-14T00:00:00Z
dateModified:2024-08-14T00:00:00Z
pageStart:442
pageEnd:450
license:http://creativecommons.org/licenses/by/4.0/
sameAs:https://doi.org/10.1038/s41586-024-07820-3
keywords:
Cell biology
Immunology
Infectious diseases
Rheumatic diseases
Science
Humanities and Social Sciences
multidisciplinary
image:
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig1_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig2_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig3_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig4_HTML.png
https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41586-024-07820-3/MediaObjects/41586_2024_7820_Fig5_HTML.png
isPartOf:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:633
type:
Periodical
PublicationVolume
publisher:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Mariano Malamud
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Lauren Whitehead
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Alasdair McIntosh
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Fabio Colella
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Anke J. Roelofs
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Takato Kusakabe
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
type:Person
name:Ivy M. Dambuza
url:http://orcid.org/0000-0001-6556-6476
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Annie Phillips-Brookes
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Fabián Salazar
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Federico Perez
affiliation:
name:Hospital for Sick Children
address:
name:Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Romey Shoesmith
url:http://orcid.org/0000-0001-6629-6172
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Przemyslaw Zakrzewski
url:http://orcid.org/0000-0003-0035-5509
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
type:Person
name:Emily A. Sey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Cecilia Rodrigues
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Petruta L. Morvay
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Pierre Redelinghuys
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Tina Bedekovic
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Maria J. G. Fernandes
affiliation:
name:Laval University
address:
name:Faculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Canada
type:PostalAddress
type:Organization
type:Person
name:Ruqayyah Almizraq
url:http://orcid.org/0000-0001-8494-6538
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Donald R. Branch
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
type:Person
name:Borko Amulic
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
type:Person
name:Jamie Harvey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Diane Stewart
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Raif Yuecel
affiliation:
name:University of Exeter
address:
name:Centre for Cytomics, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
type:Person
name:Delyth M. Reid
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Alex McConnachie
url:http://orcid.org/0000-0002-7262-7000
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Matthew C. Pickering
url:http://orcid.org/0000-0002-1153-0192
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
type:Person
name:Marina Botto
url:http://orcid.org/0000-0002-1458-3791
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
type:Person
name:Iliyan D. Iliev
url:http://orcid.org/0000-0003-0884-9749
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
type:Person
name:Iain B. McInnes
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
type:Person
name:Cosimo De Bari
url:http://orcid.org/0000-0002-5113-862X
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Janet A. Willment
url:http://orcid.org/0000-0002-7040-0857
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
type:Person
name:Gordon D. Brown
url:http://orcid.org/0000-0002-0287-5383
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
email:[email protected]
type:Person
isAccessibleForFree:1
["Periodical","PublicationVolume"]:
name:Nature
issn:
1476-4687
0028-0836
volumeNumber:633
Organization:
name:Nature Publishing Group UK
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:Hospital for Sick Children
address:
name:Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:Laval University
address:
name:Faculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Canada
type:PostalAddress
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Exeter
address:
name:Centre for Cytomics, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
ImageObject:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
name:Mariano Malamud
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Lauren Whitehead
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Alasdair McIntosh
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
name:Fabio Colella
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Anke J. Roelofs
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Takato Kusakabe
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Ivy M. Dambuza
url:http://orcid.org/0000-0001-6556-6476
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Annie Phillips-Brookes
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Fabián Salazar
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Federico Perez
affiliation:
name:Hospital for Sick Children
address:
name:Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
type:PostalAddress
type:Organization
name:Romey Shoesmith
url:http://orcid.org/0000-0001-6629-6172
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Przemyslaw Zakrzewski
url:http://orcid.org/0000-0003-0035-5509
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
name:Emily A. Sey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Cecilia Rodrigues
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Petruta L. Morvay
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Pierre Redelinghuys
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Tina Bedekovic
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Maria J. G. Fernandes
affiliation:
name:Laval University
address:
name:Faculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Canada
type:PostalAddress
type:Organization
name:Ruqayyah Almizraq
url:http://orcid.org/0000-0001-8494-6538
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
name:Donald R. Branch
affiliation:
name:Canadian Blood Services
address:
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
type:PostalAddress
type:Organization
name:Borko Amulic
affiliation:
name:University of Bristol
address:
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
type:PostalAddress
type:Organization
name:Jamie Harvey
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Diane Stewart
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Raif Yuecel
affiliation:
name:University of Exeter
address:
name:Centre for Cytomics, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:Delyth M. Reid
affiliation:
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Alex McConnachie
url:http://orcid.org/0000-0002-7262-7000
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
name:Matthew C. Pickering
url:http://orcid.org/0000-0002-1153-0192
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
name:Marina Botto
url:http://orcid.org/0000-0002-1458-3791
affiliation:
name:Imperial College London
address:
name:Department of Immunology and Inflammation, Imperial College London, London, UK
type:PostalAddress
type:Organization
name:Iliyan D. Iliev
url:http://orcid.org/0000-0003-0884-9749
affiliation:
name:Weill Cornell Medicine
address:
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Weill Cornell Medicine
address:
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
type:PostalAddress
type:Organization
name:Iain B. McInnes
affiliation:
name:University of Glasgow
address:
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
type:PostalAddress
type:Organization
name:Cosimo De Bari
url:http://orcid.org/0000-0002-5113-862X
affiliation:
name:University of Aberdeen
address:
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Janet A. Willment
url:http://orcid.org/0000-0002-7040-0857
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
name:Gordon D. Brown
url:http://orcid.org/0000-0002-0287-5383
affiliation:
name:University of Exeter
address:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
type:PostalAddress
type:Organization
name:University of Aberdeen
address:
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
type:PostalAddress
type:Organization
email:[email protected]
PostalAddress:
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Program in Cell Biology, Hospital for Sick Children, Toronto, Canada
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Faculty of Medicine, Department of Microbiology, Infectious Diseases, and Immunology, Laval University, Quebec City, Canada
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
name:Medical Affairs and Innovation, Canadian Blood Services, Toronto, Canada
name:School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:Centre for Cytomics, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
name:Department of Immunology and Inflammation, Imperial College London, London, UK
name:Department of Immunology and Inflammation, Imperial College London, London, UK
name:Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York City, USA
name:The Jill Roberts Institute for Research in Inflammatory Bowel Disease (JRI), Weill Cornell Medicine, New York City, USA
name:Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
name:Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
name:MRC Centre for Medical Mycology, University of Exeter, Exeter, UK
name:Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
External Links {🔗}(4)
Analytics and Tracking {📊}
- Google Tag Manager
Libraries {📚}
- Zoom.js
Emails and Hosting {✉️}
Mail Servers:
- mxa-002c5801.gslb.pphosted.com
- mxb-002c5801.gslb.pphosted.com
Name Servers:
- pdns1.ultradns.net
- pdns2.ultradns.net
- pdns3.ultradns.org
- pdns4.ultradns.org
- pdns5.ultradns.info
- pdns6.ultradns.co.uk