Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/s41581-018-0078-3.

Title:
The Klotho proteins in health and disease | Nature Reviews Nephrology
Description:
The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho–FGFR4 complex in hepatocytes to promote metabolic responses to feeding. By contrast, under fasting conditions, the liver secretes the starvation hormone FGF21, which induces metabolic responses to fasting and stress responses through the activation of the hypothalamus–pituitary–adrenal axis and the sympathetic nervous system following binding to the βKlotho–FGFR1c complex in adipocytes and the suprachiasmatic nucleus, respectively. Finally, FGF23 is secreted by osteocytes in response to phosphate intake and binds to αKlotho–FGFR complexes, which are expressed most abundantly in renal tubules, to regulate mineral metabolism. Growing evidence suggests that the FGF–Klotho endocrine system also has a crucial role in the pathophysiology of ageing-related disorders, including diabetes, cancer, arteriosclerosis and chronic kidney disease. Therefore, targeting the FGF–Klotho endocrine axes might have therapeutic benefit in multiple systems; investigation of the crystal structures of FGF–Klotho–FGFR complexes is paving the way for the development of drugs that can regulate these axes. Klotho proteins are crucial elements of the receptor complex for the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. In this Review, Makoto Kuro-o discusses the functions of the FGF–Klotho endocrine systems in health and disease, including their role in ageing-related disorders.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Health & Fitness

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
According to our algorithms, Nature.com's monthly online income from display advertising ranges from $357,503 to $983,134.

Keywords {🔍}

pubmed, google, scholar, cas, central, fgf, klotho, growth, factor, kidney, fibroblast, phosphate, disease, nephrol, nature, renal, chronic, metabolism, gene, cell, biol, bone, mice, endocrine, receptor, hormone, clin, soc, kuroo, metabolic, res, expression, vascular, levels, protein, human, calcification, serum, article, αklotho, calcium, mol, metab, role, invest, physiol, sci, aging, bile, mineral,

Topics {✒️}

permissions reprints nature portfolio journals privacy policy nature portfolio fgfr1/β-klotho-activating antibody act advertising corticotropin-releasing factor-producing neurons 25-dihydroxyvitamin d3/vdr-mediated induction received research funds middle-age golgi n-glycan processing αklotho–fgfr1c–fgf23 ternary complex polypeptide galnac-transferase t3 medical research cross-sectional pilot study renal ischemia-reperfusion injury research resource core research erk1/2-sgk1 signaling pathway nature med extracellular ca2+-sensing receptor α2-hs glycoprotein/fetuin fgf21 induces pgc-1α soluble alpha-klotho levels portal circulation renin-angiotensin-aldosterone system clinical index nature+ nature 390 nature 444 nature 553 nature 464 nature serum α-klotho levels social media tunica media end-stage renal disease hypothalamus–pituitary–adrenal axis nephron index vitamin d-fgf-23-klotho ageing-related receptors resolved inhibiting calcium-phosphate deposition soluble α-klotho measurement personal data aldosterone-induced protein sgk hyperphosphatemia-induced nanocrystals upregulate beta-glucuronidase klotho hydrolyzes x-linked hypophosphatemic rickets author information authors anti-aging klotho gene

Questions {❓}

  • How might circadian rhythms control mood?
  • Klotho and endocrine fibroblast growth factors: marker of chronic kidney disease progression and cardiovascular complications?
  • Potential therapeutic implications for calciphylaxis?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:The Klotho proteins in health and disease
         description:The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho–FGFR4 complex in hepatocytes to promote metabolic responses to feeding. By contrast, under fasting conditions, the liver secretes the starvation hormone FGF21, which induces metabolic responses to fasting and stress responses through the activation of the hypothalamus–pituitary–adrenal axis and the sympathetic nervous system following binding to the βKlotho–FGFR1c complex in adipocytes and the suprachiasmatic nucleus, respectively. Finally, FGF23 is secreted by osteocytes in response to phosphate intake and binds to αKlotho–FGFR complexes, which are expressed most abundantly in renal tubules, to regulate mineral metabolism. Growing evidence suggests that the FGF–Klotho endocrine system also has a crucial role in the pathophysiology of ageing-related disorders, including diabetes, cancer, arteriosclerosis and chronic kidney disease. Therefore, targeting the FGF–Klotho endocrine axes might have therapeutic benefit in multiple systems; investigation of the crystal structures of FGF–Klotho–FGFR complexes is paving the way for the development of drugs that can regulate these axes. Klotho proteins are crucial elements of the receptor complex for the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. In this Review, Makoto Kuro-o discusses the functions of the FGF–Klotho endocrine systems in health and disease, including their role in ageing-related disorders.
         datePublished:2018-11-19T00:00:00Z
         dateModified:2018-11-19T00:00:00Z
         pageStart:27
         pageEnd:44
         sameAs:https://doi.org/10.1038/s41581-018-0078-3
         keywords:
            Ageing
            Calcium and phosphate metabolic disorders
            Chronic kidney disease
            Endocrine system and metabolic diseases
            Medicine/Public Health
            general
            Nephrology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig7_HTML.png
         isPartOf:
            name:Nature Reviews Nephrology
            issn:
               1759-507X
               1759-5061
            volumeNumber:15
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Makoto Kuro-o
               affiliation:
                     name:Jichi Medical University
                     address:
                        name:Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan
                        type:PostalAddress
                     type:Organization
                     name:University of Texas Southwestern Medical Center
                     address:
                        name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:The Klotho proteins in health and disease
      description:The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity binding of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs). Collectively, these proteins form a unique endocrine system that governs multiple metabolic processes in mammals. FGF19 is a satiety hormone that is secreted from the intestine on ingestion of food and binds the βKlotho–FGFR4 complex in hepatocytes to promote metabolic responses to feeding. By contrast, under fasting conditions, the liver secretes the starvation hormone FGF21, which induces metabolic responses to fasting and stress responses through the activation of the hypothalamus–pituitary–adrenal axis and the sympathetic nervous system following binding to the βKlotho–FGFR1c complex in adipocytes and the suprachiasmatic nucleus, respectively. Finally, FGF23 is secreted by osteocytes in response to phosphate intake and binds to αKlotho–FGFR complexes, which are expressed most abundantly in renal tubules, to regulate mineral metabolism. Growing evidence suggests that the FGF–Klotho endocrine system also has a crucial role in the pathophysiology of ageing-related disorders, including diabetes, cancer, arteriosclerosis and chronic kidney disease. Therefore, targeting the FGF–Klotho endocrine axes might have therapeutic benefit in multiple systems; investigation of the crystal structures of FGF–Klotho–FGFR complexes is paving the way for the development of drugs that can regulate these axes. Klotho proteins are crucial elements of the receptor complex for the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. In this Review, Makoto Kuro-o discusses the functions of the FGF–Klotho endocrine systems in health and disease, including their role in ageing-related disorders.
      datePublished:2018-11-19T00:00:00Z
      dateModified:2018-11-19T00:00:00Z
      pageStart:27
      pageEnd:44
      sameAs:https://doi.org/10.1038/s41581-018-0078-3
      keywords:
         Ageing
         Calcium and phosphate metabolic disorders
         Chronic kidney disease
         Endocrine system and metabolic diseases
         Medicine/Public Health
         general
         Nephrology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41581-018-0078-3/MediaObjects/41581_2018_78_Fig7_HTML.png
      isPartOf:
         name:Nature Reviews Nephrology
         issn:
            1759-507X
            1759-5061
         volumeNumber:15
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Makoto Kuro-o
            affiliation:
                  name:Jichi Medical University
                  address:
                     name:Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan
                     type:PostalAddress
                  type:Organization
                  name:University of Texas Southwestern Medical Center
                  address:
                     name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature Reviews Nephrology
      issn:
         1759-507X
         1759-5061
      volumeNumber:15
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Jichi Medical University
      address:
         name:Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan
         type:PostalAddress
      name:University of Texas Southwestern Medical Center
      address:
         name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Makoto Kuro-o
      affiliation:
            name:Jichi Medical University
            address:
               name:Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan
               type:PostalAddress
            type:Organization
            name:University of Texas Southwestern Medical Center
            address:
               name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Division of Anti-aging Medicine, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan
      name:Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(484)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Particles.js
  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

4.73s.