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We are analyzing https://www.nature.com/articles/s41577-021-00577-0.

Title:
Regulation of the nucleic acid-sensing Toll-like receptors | Nature Reviews Immunology
Description:
Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that receptor activation unequivocally indicates the presence of something foreign. However, a subset of TLRs recognizes nucleic acids, which are present in both the host and foreign microorganisms. This specificity enables broad recognition by virtue of the ubiquity of nucleic acids but also introduces the possibility of self-recognition and autoinflammatory or autoimmune disease. Defining the regulatory mechanisms required to ensure proper discrimination between foreign and self-nucleic acids by TLRs is an area of intense research. Progress over the past decade has revealed a complex array of regulatory mechanisms that ensure maintenance of this delicate balance. These regulatory mechanisms can be divided into a conceptual framework with four categories: compartmentalization, ligand availability, receptor expression and signal transduction. In this Review, we discuss our current understanding of each of these layers of regulation. Activation of nucleic acid-sensing Toll-like receptors is finely tuned to limit self-reactivity while maintaining recognition of foreign microorganisms. The authors describe recent progress made in defining the regulatory mechanisms that facilitate this delicate balance.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Education
  • Science
  • Business & Finance

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

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How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$536,300 per month
Our analysis indicates Nature.com generates between $357,503 and $983,134 monthly online from display ads.

Keywords {🔍}

pubmed, google, scholar, cas, central, tlr, tolllike, receptor, nature, immunol, nat, cells, cell, dna, receptors, immunity, lupus, rna, uncb, systemic, dendritic, human, erythematosus, article, activation, signaling, nucleic, recognition, access, responses, immune, tlrs, expression, autoimmunity, sci, cpg, med, content, barton, disease, mice, science, interferon, research, paper, usa, inflammation, exp, type, genet,

Topics {✒️}

permissions reprints nature portfolio journals privacy policy cancer research institute pi3k/mir-136-5p/akt3 pathway nature portfolio advertising social media intense research development china cpg sequence-dependent manner single-stranded acid exonucleases dnase ii-deficient mice author correspondence human unc-93b deficiency erythromycin resistance-forming modification chromatin–igg complexes activate myd88-dependent autoantibody production authors researched data hermansky–pudlak syndrome proteins links tlr–myd88 signaling tlr9-mediated inflammatory responses cytosolic double-stranded dna familial rosai–dorfman disease rna-related antigens due interferon-dependent immune responses dna-dependent inflammatory disease nucleic acid-sensing tlrs interferon-α production induced permissions cell antigen receptor/toll human myeloid cells peer review promotes inflammatory responses springerlink instant access personal data nucleic acid-sensing toll nature+ nature 449 nature 374 nature 416 nature 452 nature 575 nature 456 nature 520 nature 443 nature 581 nature 434 nature 440

Schema {🗺️}

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