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We are analyzing https://www.nature.com/articles/s41467-022-28306-8.

Title:
Alternative splicing in seasonal plasticity and the potential for adaptation to environmental change | Nature Communications
Description:
Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular mechanisms contribute to plasticity or how these mechanisms impact how plasticity evolves. Here, we use transcriptomic and genomic data from the butterfly Bicyclus anynana, a model system for seasonal plasticity, to compare the extent of differential expression and splicing and test how these axes of transcriptional plasticity differ in their potential for evolutionary change. Between seasonal morphs, we find that differential splicing affects a smaller but functionally unique set of genes compared to differential expression. Further, we find strong support for the novel hypothesis that spliced genes are more susceptible than differentially expressed genes to erosion of genetic variation due to selection on seasonal plasticity. Our results suggest that splicing plasticity is especially likely to experience genetic constraints that could affect the potential of wild populations to respond to rapidly changing environments. Little is known about how alternative splicing and other post-transcriptional molecular mechanisms impact plasticity. Steward et al. use transcriptomic and genomic data from the butterfly Bicyclus anynana, finding that splicing plasticity is likely to experience genetic constraints.
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30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

genes, expression, splicing, pubmed, article, gene, differentially, google, scholar, differential, exon, alternative, plasticity, supplementary, seasonal, spliced, fig, expressed, data, variation, cas, central, splice, events, exons, genetic, analyses, abdomen, selection, nucleotide, thorax, anynana, evolution, season, reads, divergence, compared, family, nature, samples, diversity, table, morphs, phenotypic, population, change, differences, event, tissues, families,

Topics {✒️}

nature portfolio scientific research privacy policy advertising alternative solutions regional patterns nature social media library preparation swedish research council illumina fragment libraries language reprints potentially providing access supplementary data files open source softw replicate rna-seq data china genomic research simulation-based comprehensive benchmarking original author research design cis-regulatory motifs affecting cis-acting regulatory motifs source data file quality-based trimming tool nonsense-mediated mrna decay leave long-term signatures facultative diapause rachel cold-adapted fly populations event-based tool rmats rmats event-based approach high-coverage draft genome caste-biased gene expression libraries permissions pipe-friendly framework average gene-wide expression sex-specific selection drives edger quasi-likelihood pipeline exon expression-based approach high-throughput sequencing reads accepted adjusted p-values research comprehensive annotation-free analysis complex multi-trait responses rna sequence data long-term constraint depends open sci supplementary information file

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         description:Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular mechanisms contribute to plasticity or how these mechanisms impact how plasticity evolves. Here, we use transcriptomic and genomic data from the butterfly Bicyclus anynana, a model system for seasonal plasticity, to compare the extent of differential expression and splicing and test how these axes of transcriptional plasticity differ in their potential for evolutionary change. Between seasonal morphs, we find that differential splicing affects a smaller but functionally unique set of genes compared to differential expression. Further, we find strong support for the novel hypothesis that spliced genes are more susceptible than differentially expressed genes to erosion of genetic variation due to selection on seasonal plasticity. Our results suggest that splicing plasticity is especially likely to experience genetic constraints that could affect the potential of wild populations to respond to rapidly changing environments. Little is known about how alternative splicing and other post-transcriptional molecular mechanisms impact plasticity. Steward et al. use transcriptomic and genomic data from the butterfly Bicyclus anynana, finding that splicing plasticity is likely to experience genetic constraints.
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      description:Seasonal plasticity is accomplished via tightly regulated developmental cascades that translate environmental cues into trait changes. Little is known about how alternative splicing and other posttranscriptional molecular mechanisms contribute to plasticity or how these mechanisms impact how plasticity evolves. Here, we use transcriptomic and genomic data from the butterfly Bicyclus anynana, a model system for seasonal plasticity, to compare the extent of differential expression and splicing and test how these axes of transcriptional plasticity differ in their potential for evolutionary change. Between seasonal morphs, we find that differential splicing affects a smaller but functionally unique set of genes compared to differential expression. Further, we find strong support for the novel hypothesis that spliced genes are more susceptible than differentially expressed genes to erosion of genetic variation due to selection on seasonal plasticity. Our results suggest that splicing plasticity is especially likely to experience genetic constraints that could affect the potential of wild populations to respond to rapidly changing environments. Little is known about how alternative splicing and other post-transcriptional molecular mechanisms impact plasticity. Steward et al. use transcriptomic and genomic data from the butterfly Bicyclus anynana, finding that splicing plasticity is likely to experience genetic constraints.
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