Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Schema
  10. Social Networks
  11. External Links
  12. Analytics And Tracking
  13. Libraries
  14. Hosting Providers
  15. CDN Services

We are analyzing https://www.nature.com/articles/s41467-021-23949-5.

Title:
Single cell derived mRNA signals across human kidney tumors | Nature Communications
Description:
Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference “cellular signals” in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of “fetalness” with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer. Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Telecommunications
  • Science
  • Education

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$63,100 per month
Our analysis indicates Nature.com generates between $42,042 and $115,616 monthly online from display ads.

Keywords {🔍}

cell, data, cells, reference, single, signal, bulk, tumor, kidney, transcriptomes, signals, fig, fetal, tumors, cellular, renal, article, type, cancer, human, model, supplementary, analysis, normal, google, scholar, transcriptome, distribution, gene, contribution, population, mature, score, set, samples, wilms, mesenchymal, populations, genes, expression, childhood, sample, nature, tissue, cmn, mrt, derived, cas, cambridge, mrna,

Topics {✒️}

project id abe1a013-af7a-45ed-8c26-f3793c24a1f4 }_{{gp}}={\beta }_{0p}+{\beta }_{1p}{ nature portfolio privacy policy }_{g2}+\ldots +{\beta }_{{np}}{ open source software joint mrc/wellcome trust-funded index-jumping event advertising }_{{gc}}{\beta }_{{cp}}$$ }_{{gc}}}{\mathop{\sum}\limits_{ }_{g1}+{\beta }_{2p}{ congenital mesoblastic nephroma {\lambda }_{{gp}}^{{\prime} }-{ {\lambda }_{{gp}}^{{\prime} } social media national health service single-nucleus rna-sequencing pipeline reprints }}}_{\text{full}}}{{{\log }}{{\mathscr{ tcga research network s-shaped body medial single-cell rna-seq single-cell rna sequencing }_{{gc}}={{\log }}\left european research council nature 464 nature 566 nature 499 nature 581 nature acute lymphoblastic leukemia van den heuvel-eibrink heat-induced epitope retrieval single-cell transcriptomic data single-cell transcriptomic map single-cell molecular map channel-specific hrp reagents soft-clipped reads reporting european genome-phenome archive mapping human development reproducible rna-seq analysis atypical teratoid/rhabdoid tumor bulk rna-seq data single-cell transcriptomes reveal therapeutically applicable research congenital mesoblastic nephromas congenital mesoblastic nephroma22 cell-type-specific gene programs nihr cambridge brc

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Single cell derived mRNA signals across human kidney tumors
         description:Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference “cellular signals” in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of “fetalness” with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer. Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
         datePublished:2021-06-23T00:00:00Z
         dateModified:2021-06-23T00:00:00Z
         pageStart:1
         pageEnd:19
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41467-021-23949-5
         keywords:
            Cancer genomics
            Transcriptomics
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig7_HTML.png
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:12
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Matthew D. Young
               url:http://orcid.org/0000-0003-0937-5290
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Thomas J. Mitchell
               url:http://orcid.org/0000-0003-0761-9503
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Surgery, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lars Custers
               url:http://orcid.org/0000-0003-0252-7714
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Oncode Institute
                     address:
                        name:Oncode Institute, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thanasis Margaritis
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Francisco Morales-Rodriguez
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Oncode Institute
                     address:
                        name:Oncode Institute, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kwasi Kwakwa
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eleonora Khabirova
               url:http://orcid.org/0000-0002-5891-6789
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gerda Kildisiute
               url:http://orcid.org/0000-0002-5314-2294
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Thomas R. W. Oliver
               url:http://orcid.org/0000-0003-4306-0102
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ronald R. de Krijger
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Utrecht
                     address:
                        name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marry M. van den Heuvel-Eibrink
               url:http://orcid.org/0000-0002-7760-879X
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Federico Comitani
               url:http://orcid.org/0000-0003-3226-1179
               affiliation:
                     name:The Hospital for Sick Children
                     address:
                        name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Alice Piapi
               url:http://orcid.org/0000-0001-8251-3309
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Eva Bugallo-Blanco
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christine Thevanesan
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christina Burke
               url:http://orcid.org/0000-0001-5381-3185
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Elena Prigmore
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kirsty Ambridge
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kenny Roberts
               url:http://orcid.org/0000-0001-6155-0821
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Felipe A. Vieira Braga
               affiliation:
                     name:University of Amsterdam
                     address:
                        name:Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tim H. H. Coorens
               url:http://orcid.org/0000-0002-5826-3554
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ignacio Del Valle
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anna Wilbrey-Clark
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lira Mamanova
               url:http://orcid.org/0000-0003-1463-8622
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Grant D. Stewart
               url:http://orcid.org/0000-0003-3188-9140
               affiliation:
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Surgery, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vincent J. Gnanapragasam
               affiliation:
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Surgery, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge
                     address:
                        name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dyanne Rampling
               affiliation:
                     name:Great Ormond Street Hospital for Children NHS Foundation Trust
                     address:
                        name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Neil Sebire
               affiliation:
                     name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health
                     address:
                        name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nicholas Coleman
               affiliation:
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Pathology, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Liz Hook
               affiliation:
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Pathology, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Anne Warren
               url:http://orcid.org/0000-0002-1170-7867
               affiliation:
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Muzlifah Haniffa
               url:http://orcid.org/0000-0002-3927-2084
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:Newcastle Hospitals NHS Foundation Trust
                     address:
                        name:Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
                        type:PostalAddress
                     type:Organization
                     name:Newcastle University
                     address:
                        name:Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Marcel Kool
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
                     address:
                        name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Division of Pediatric Neurooncology
                     address:
                        name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Stefan M. Pfister
               affiliation:
                     name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
                     address:
                        name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Division of Pediatric Neurooncology
                     address:
                        name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology
                     address:
                        name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John C. Achermann
               url:http://orcid.org/0000-0001-8787-6272
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xiaoling He
               affiliation:
                     name:University of Cambridge
                     address:
                        name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Roger A. Barker
               affiliation:
                     name:University of Cambridge
                     address:
                        name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Adam Shlien
               affiliation:
                     name:The Hospital for Sick Children
                     address:
                        name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:University of Toronto
                     address:
                        name:Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
                        type:PostalAddress
                     type:Organization
                     name:The Hospital for Sick Children
                     address:
                        name:Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Omer A. Bayraktar
               url:http://orcid.org/0000-0001-6055-277X
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sarah A. Teichmann
               url:http://orcid.org/0000-0002-6294-6366
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Cavendish Laboratory, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Frank C. Holstege
               url:http://orcid.org/0000-0002-8090-5146
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kerstin B. Meyer
               url:http://orcid.org/0000-0001-5906-1498
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jarno Drost
               url:http://orcid.org/0000-0002-2941-6179
               affiliation:
                     name:Princess Máxima Center for Pediatric Oncology
                     address:
                        name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
                     name:Oncode Institute
                     address:
                        name:Oncode Institute, Utrecht, The Netherlands
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Karin Straathof
               url:http://orcid.org/0000-0001-9673-8568
               affiliation:
                     name:UCL Great Ormond Street Hospital Institute of Child Health
                     address:
                        name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                        type:PostalAddress
                     type:Organization
                     name:Great Ormond Street Hospital for Children NHS Foundation Trust
                     address:
                        name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Sam Behjati
               url:http://orcid.org/0000-0002-6600-7665
               affiliation:
                     name:Wellcome Genome Campus, Hinxton
                     address:
                        name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:Cambridge University Hospitals NHS Foundation Trust
                     address:
                        name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                        type:PostalAddress
                     type:Organization
                     name:University of Cambridge
                     address:
                        name:Department of Paediatrics, University of Cambridge, Cambridge, UK
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Single cell derived mRNA signals across human kidney tumors
      description:Tumor cells may share some patterns of gene expression with their cell of origin, providing clues into the differentiation state and origin of cancer. Here, we study the differentiation state and cellular origin of 1300 childhood and adult kidney tumors. Using single cell mRNA reference maps of normal tissues, we quantify reference “cellular signals” in each tumor. Quantifying global differentiation, we find that childhood tumors exhibit fetal cellular signals, replacing the presumption of “fetalness” with a quantitative measure of immaturity. By contrast, in adult cancers our assessment refutes the suggestion of dedifferentiation towards a fetal state in most cases. We find an intimate connection between developmental mesenchymal populations and childhood renal tumors. We demonstrate the diagnostic potential of our approach with a case study of a cryptic renal tumor. Our findings provide a cellular definition of human renal tumors through an approach that is broadly applicable to human cancer. Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.
      datePublished:2021-06-23T00:00:00Z
      dateModified:2021-06-23T00:00:00Z
      pageStart:1
      pageEnd:19
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41467-021-23949-5
      keywords:
         Cancer genomics
         Transcriptomics
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-021-23949-5/MediaObjects/41467_2021_23949_Fig7_HTML.png
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:12
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Matthew D. Young
            url:http://orcid.org/0000-0003-0937-5290
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Thomas J. Mitchell
            url:http://orcid.org/0000-0003-0761-9503
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Surgery, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lars Custers
            url:http://orcid.org/0000-0003-0252-7714
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Oncode Institute
                  address:
                     name:Oncode Institute, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thanasis Margaritis
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Francisco Morales-Rodriguez
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Oncode Institute
                  address:
                     name:Oncode Institute, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kwasi Kwakwa
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eleonora Khabirova
            url:http://orcid.org/0000-0002-5891-6789
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gerda Kildisiute
            url:http://orcid.org/0000-0002-5314-2294
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Thomas R. W. Oliver
            url:http://orcid.org/0000-0003-4306-0102
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ronald R. de Krijger
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Utrecht
                  address:
                     name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marry M. van den Heuvel-Eibrink
            url:http://orcid.org/0000-0002-7760-879X
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Federico Comitani
            url:http://orcid.org/0000-0003-3226-1179
            affiliation:
                  name:The Hospital for Sick Children
                  address:
                     name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Alice Piapi
            url:http://orcid.org/0000-0001-8251-3309
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Eva Bugallo-Blanco
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christine Thevanesan
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christina Burke
            url:http://orcid.org/0000-0001-5381-3185
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Elena Prigmore
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kirsty Ambridge
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kenny Roberts
            url:http://orcid.org/0000-0001-6155-0821
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Felipe A. Vieira Braga
            affiliation:
                  name:University of Amsterdam
                  address:
                     name:Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tim H. H. Coorens
            url:http://orcid.org/0000-0002-5826-3554
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ignacio Del Valle
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anna Wilbrey-Clark
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lira Mamanova
            url:http://orcid.org/0000-0003-1463-8622
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Grant D. Stewart
            url:http://orcid.org/0000-0003-3188-9140
            affiliation:
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Surgery, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vincent J. Gnanapragasam
            affiliation:
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Surgery, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge
                  address:
                     name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dyanne Rampling
            affiliation:
                  name:Great Ormond Street Hospital for Children NHS Foundation Trust
                  address:
                     name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Neil Sebire
            affiliation:
                  name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health
                  address:
                     name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nicholas Coleman
            affiliation:
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Pathology, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Liz Hook
            affiliation:
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Pathology, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Anne Warren
            url:http://orcid.org/0000-0002-1170-7867
            affiliation:
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Muzlifah Haniffa
            url:http://orcid.org/0000-0002-3927-2084
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:Newcastle Hospitals NHS Foundation Trust
                  address:
                     name:Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
                     type:PostalAddress
                  type:Organization
                  name:Newcastle University
                  address:
                     name:Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Marcel Kool
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
                  address:
                     name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Division of Pediatric Neurooncology
                  address:
                     name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Stefan M. Pfister
            affiliation:
                  name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
                  address:
                     name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Division of Pediatric Neurooncology
                  address:
                     name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology
                  address:
                     name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John C. Achermann
            url:http://orcid.org/0000-0001-8787-6272
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xiaoling He
            affiliation:
                  name:University of Cambridge
                  address:
                     name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Roger A. Barker
            affiliation:
                  name:University of Cambridge
                  address:
                     name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Adam Shlien
            affiliation:
                  name:The Hospital for Sick Children
                  address:
                     name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:University of Toronto
                  address:
                     name:Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
                     type:PostalAddress
                  type:Organization
                  name:The Hospital for Sick Children
                  address:
                     name:Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Omer A. Bayraktar
            url:http://orcid.org/0000-0001-6055-277X
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sarah A. Teichmann
            url:http://orcid.org/0000-0002-6294-6366
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Cavendish Laboratory, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Frank C. Holstege
            url:http://orcid.org/0000-0002-8090-5146
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kerstin B. Meyer
            url:http://orcid.org/0000-0001-5906-1498
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jarno Drost
            url:http://orcid.org/0000-0002-2941-6179
            affiliation:
                  name:Princess Máxima Center for Pediatric Oncology
                  address:
                     name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
                  name:Oncode Institute
                  address:
                     name:Oncode Institute, Utrecht, The Netherlands
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Karin Straathof
            url:http://orcid.org/0000-0001-9673-8568
            affiliation:
                  name:UCL Great Ormond Street Hospital Institute of Child Health
                  address:
                     name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
                     type:PostalAddress
                  type:Organization
                  name:Great Ormond Street Hospital for Children NHS Foundation Trust
                  address:
                     name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Sam Behjati
            url:http://orcid.org/0000-0002-6600-7665
            affiliation:
                  name:Wellcome Genome Campus, Hinxton
                  address:
                     name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:Cambridge University Hospitals NHS Foundation Trust
                  address:
                     name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
                     type:PostalAddress
                  type:Organization
                  name:University of Cambridge
                  address:
                     name:Department of Paediatrics, University of Cambridge, Cambridge, UK
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:12
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Surgery, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Oncode Institute
      address:
         name:Oncode Institute, Utrecht, The Netherlands
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Oncode Institute
      address:
         name:Oncode Institute, Utrecht, The Netherlands
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:University Medical Center Utrecht
      address:
         name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:The Hospital for Sick Children
      address:
         name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:University of Amsterdam
      address:
         name:Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Surgery, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Surgery, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge
      address:
         name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Great Ormond Street Hospital for Children NHS Foundation Trust
      address:
         name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
         type:PostalAddress
      name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health
      address:
         name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Pathology, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Pathology, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Newcastle Hospitals NHS Foundation Trust
      address:
         name:Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
         type:PostalAddress
      name:Newcastle University
      address:
         name:Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
      address:
         name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
         type:PostalAddress
      name:Division of Pediatric Neurooncology
      address:
         name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
         type:PostalAddress
      name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
      address:
         name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
         type:PostalAddress
      name:Division of Pediatric Neurooncology
      address:
         name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
         type:PostalAddress
      name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology
      address:
         name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:The Hospital for Sick Children
      address:
         name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
         type:PostalAddress
      name:University of Toronto
      address:
         name:Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
         type:PostalAddress
      name:The Hospital for Sick Children
      address:
         name:Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Cavendish Laboratory, University of Cambridge, Cambridge, UK
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Princess Máxima Center for Pediatric Oncology
      address:
         name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
         type:PostalAddress
      name:Oncode Institute
      address:
         name:Oncode Institute, Utrecht, The Netherlands
         type:PostalAddress
      name:UCL Great Ormond Street Hospital Institute of Child Health
      address:
         name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
         type:PostalAddress
      name:Great Ormond Street Hospital for Children NHS Foundation Trust
      address:
         name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
         type:PostalAddress
      name:Wellcome Genome Campus, Hinxton
      address:
         name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
         type:PostalAddress
      name:Cambridge University Hospitals NHS Foundation Trust
      address:
         name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
         type:PostalAddress
      name:University of Cambridge
      address:
         name:Department of Paediatrics, University of Cambridge, Cambridge, UK
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Matthew D. Young
      url:http://orcid.org/0000-0003-0937-5290
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Thomas J. Mitchell
      url:http://orcid.org/0000-0003-0761-9503
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Surgery, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Lars Custers
      url:http://orcid.org/0000-0003-0252-7714
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:Oncode Institute
            address:
               name:Oncode Institute, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Thanasis Margaritis
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Francisco Morales-Rodriguez
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:Oncode Institute
            address:
               name:Oncode Institute, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Kwasi Kwakwa
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Eleonora Khabirova
      url:http://orcid.org/0000-0002-5891-6789
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Gerda Kildisiute
      url:http://orcid.org/0000-0002-5314-2294
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Thomas R. W. Oliver
      url:http://orcid.org/0000-0003-4306-0102
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Ronald R. de Krijger
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:University Medical Center Utrecht
            address:
               name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Marry M. van den Heuvel-Eibrink
      url:http://orcid.org/0000-0002-7760-879X
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Federico Comitani
      url:http://orcid.org/0000-0003-3226-1179
      affiliation:
            name:The Hospital for Sick Children
            address:
               name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Alice Piapi
      url:http://orcid.org/0000-0001-8251-3309
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Eva Bugallo-Blanco
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Christine Thevanesan
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Christina Burke
      url:http://orcid.org/0000-0001-5381-3185
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Elena Prigmore
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Kirsty Ambridge
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Kenny Roberts
      url:http://orcid.org/0000-0001-6155-0821
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Felipe A. Vieira Braga
      affiliation:
            name:University of Amsterdam
            address:
               name:Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Tim H. H. Coorens
      url:http://orcid.org/0000-0002-5826-3554
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Ignacio Del Valle
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Anna Wilbrey-Clark
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Lira Mamanova
      url:http://orcid.org/0000-0003-1463-8622
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Grant D. Stewart
      url:http://orcid.org/0000-0003-3188-9140
      affiliation:
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Surgery, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Vincent J. Gnanapragasam
      affiliation:
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Surgery, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge
            address:
               name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Dyanne Rampling
      affiliation:
            name:Great Ormond Street Hospital for Children NHS Foundation Trust
            address:
               name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
               type:PostalAddress
            type:Organization
      name:Neil Sebire
      affiliation:
            name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health
            address:
               name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Nicholas Coleman
      affiliation:
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Pathology, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Liz Hook
      affiliation:
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Pathology, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Anne Warren
      url:http://orcid.org/0000-0002-1170-7867
      affiliation:
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Muzlifah Haniffa
      url:http://orcid.org/0000-0002-3927-2084
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:Newcastle Hospitals NHS Foundation Trust
            address:
               name:Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
               type:PostalAddress
            type:Organization
            name:Newcastle University
            address:
               name:Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
               type:PostalAddress
            type:Organization
      name:Marcel Kool
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
            address:
               name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Division of Pediatric Neurooncology
            address:
               name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:Stefan M. Pfister
      affiliation:
            name:Hopp Children´s Cancer Center Heidelberg (KiTZ)
            address:
               name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Division of Pediatric Neurooncology
            address:
               name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology
            address:
               name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany
               type:PostalAddress
            type:Organization
      name:John C. Achermann
      url:http://orcid.org/0000-0001-8787-6272
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
      name:Xiaoling He
      affiliation:
            name:University of Cambridge
            address:
               name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Roger A. Barker
      affiliation:
            name:University of Cambridge
            address:
               name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Adam Shlien
      affiliation:
            name:The Hospital for Sick Children
            address:
               name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:University of Toronto
            address:
               name:Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
               type:PostalAddress
            type:Organization
            name:The Hospital for Sick Children
            address:
               name:Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada
               type:PostalAddress
            type:Organization
      name:Omer A. Bayraktar
      url:http://orcid.org/0000-0001-6055-277X
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Sarah A. Teichmann
      url:http://orcid.org/0000-0002-6294-6366
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Cavendish Laboratory, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Frank C. Holstege
      url:http://orcid.org/0000-0002-8090-5146
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Kerstin B. Meyer
      url:http://orcid.org/0000-0001-5906-1498
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
      name:Jarno Drost
      url:http://orcid.org/0000-0002-2941-6179
      affiliation:
            name:Princess Máxima Center for Pediatric Oncology
            address:
               name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
            name:Oncode Institute
            address:
               name:Oncode Institute, Utrecht, The Netherlands
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Karin Straathof
      url:http://orcid.org/0000-0001-9673-8568
      affiliation:
            name:UCL Great Ormond Street Hospital Institute of Child Health
            address:
               name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
               type:PostalAddress
            type:Organization
            name:Great Ormond Street Hospital for Children NHS Foundation Trust
            address:
               name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Sam Behjati
      url:http://orcid.org/0000-0002-6600-7665
      affiliation:
            name:Wellcome Genome Campus, Hinxton
            address:
               name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:Cambridge University Hospitals NHS Foundation Trust
            address:
               name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
               type:PostalAddress
            type:Organization
            name:University of Cambridge
            address:
               name:Department of Paediatrics, University of Cambridge, Cambridge, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Surgery, University of Cambridge, Cambridge, UK
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Oncode Institute, Utrecht, The Netherlands
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Oncode Institute, Utrecht, The Netherlands
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Surgery, University of Cambridge, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Surgery, University of Cambridge, Cambridge, UK
      name:Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK
      name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
      name:NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Pathology, University of Cambridge, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Pathology, University of Cambridge, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
      name:Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
      name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
      name:Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
      name:German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany
      name:Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
      name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
      name:MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK
      name:Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK
      name:Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
      name:Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
      name:Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Canada
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Cavendish Laboratory, University of Cambridge, Cambridge, UK
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
      name:Oncode Institute, Utrecht, The Netherlands
      name:UCL Great Ormond Street Hospital Institute of Child Health, London, UK
      name:Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
      name:Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK
      name:Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
      name:Department of Paediatrics, University of Cambridge, Cambridge, UK

External Links {🔗}(242)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

6.03s.