Here's how NATURE.COM makes money* and how much!

*Please read our disclaimer before using our estimates.
Loading...

NATURE . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Nature.com Make Money
  6. How Much Does Nature.com Make
  7. Keywords
  8. Topics
  9. Questions
  10. Schema
  11. Social Networks
  12. External Links
  13. Analytics And Tracking
  14. Libraries
  15. Hosting Providers
  16. CDN Services

We are analyzing https://www.nature.com/articles/s41467-020-15497-1.

Title:
Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation | Nature Communications
Description:
Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3 inflammasome activation in murine and human cells. Mice expressing active KrasG12D in the hematopoietic system developed myeloproliferation and cytopenia, which is reversed in KrasG12D mice lacking NLRP3 in the hematopoietic system. Therapeutic IL-1-receptor blockade or NLRP3-inhibition reduces myeloproliferation and improves hematopoiesis. Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation. In agreement with our observations in mice, patient-derived myeloid leukemia cells exhibit KRAS/RAC1/ROS/NLRP3/IL-1β axis activity. Our findings indicate that oncogenic KRAS not only act via its canonical oncogenic driver function, but also enhances the activation of the pro-inflammatory RAC1/ROS/NLRP3/IL-1β axis. This paves the way for a therapeutic approach based on immune modulation via NLRP3 blockade in KRAS-mutant myeloid malignancies. Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.
Website Age:
30 years and 10 months (reg. 1994-08-11).

Matching Content Categories {📚}

  • Science
  • Education
  • Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,194,993 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}


Display Ads {🎯}


The website utilizes display ads within its content to generate revenue. Check the next section for further revenue estimates.

Ads are managed by yourbow.com. Particular relationships are as follows:

Direct Advertisers (10)
google.com, pmc.com, doceree.com, yourbow.com, audienciad.com, onlinemediasolutions.com, advibe.media, aps.amazon.com, getmediamx.com, onomagic.com

Reseller Advertisers (38)
conversantmedia.com, rubiconproject.com, pubmatic.com, appnexus.com, openx.com, smartadserver.com, lijit.com, sharethrough.com, video.unrulymedia.com, google.com, yahoo.com, triplelift.com, onetag.com, sonobi.com, contextweb.com, 33across.com, indexexchange.com, media.net, themediagrid.com, adform.com, richaudience.com, sovrn.com, improvedigital.com, freewheel.tv, smaato.com, yieldmo.com, amxrtb.com, adyoulike.com, adpone.com, criteo.com, smilewanted.com, 152media.info, e-planning.net, smartyads.com, loopme.com, opera.com, mediafuse.com, betweendigital.com

How Much Does Nature.com Make? {💰}


Display Ads {🎯}

$531,700 per month
Our analysis indicates Nature.com generates between $354,480 and $974,820 monthly online from display ads.

Keywords {🔍}

krasgd, mice, nlrp, cells, fig, bmdcs, ilβ, article, pubmed, krasmut, activation, patients, data, google, scholar, inflammasome, kras, cell, freiburg, increased, expression, caspase, production, leukemia, compared, normalized, cas, analysis, oncogenic, shown, ros, myeloid, cmml, supplementary, experiments, university, shows, representative, nature, blood, nonkrasmut, jmml, generated, mutations, observed, blot, treated, stimulation, change, isolated,

Topics {✒️}

nature portfolio pro-inflammatory rac1/ros/nlrp3/il-1β axis privacy policy reduced kras/nlrp3/il-1β axis rac1/ros/nlrp3/il-1β axis kras/ros/nlrp3/il-1β axis advertising sequencing libraries graft-versus-host disease social media kras/rac1/ros/nlrp3 axis ras/extracellular-signal-regulated kinase kras/nlrp3/il-1β axis constant ras/mek/erk signaling pro-il-1β rna transcription reactive oxygen species nature nature 445 nlrp3/caspase-1/il-1β axis language reprints memory stage-dependent manner strain termed rosa26-cre-ert2 access id gse131885 hbss/ca2+/mg2+ solution supplementary tables s1–s3 bio-rad laboratories gmbh pro-il-1β maturation19 rac1/ros/nlrp3 axis bd cytofix/cytoperm kit nlrp3/il-1β axis single-channel array normalization bone marrow transplantation multiparameter high-dimensional data blocking il-1β reverses inflammation-related molecules il-1514 direct pro-proliferative effect kras-mutant myeloid malignancies enzyme-linked immunosorbent assay linked anti-rabbit igg promoting cell death z-score log2 intensity tlr4/myd88/triff signaling therapeutic il-1-receptor blockade kras-driven hematological malignancies cell research rosa26-cre-ert2 transgenic36 visualizing single-cell data multiple inflammation-related genes kras-mutant myeloid neoplasms

Questions {❓}

  • Juvenile myelomonocytic leukemia: who’s the driver at the wheel?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
         description:Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3 inflammasome activation in murine and human cells. Mice expressing active KrasG12D in the hematopoietic system developed myeloproliferation and cytopenia, which is reversed in KrasG12D mice lacking NLRP3 in the hematopoietic system. Therapeutic IL-1-receptor blockade or NLRP3-inhibition reduces myeloproliferation and improves hematopoiesis. Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation. In agreement with our observations in mice, patient-derived myeloid leukemia cells exhibit KRAS/RAC1/ROS/NLRP3/IL-1β axis activity. Our findings indicate that oncogenic KRAS not only act via its canonical oncogenic driver function, but also enhances the activation of the pro-inflammatory RAC1/ROS/NLRP3/IL-1β axis. This paves the way for a therapeutic approach based on immune modulation via NLRP3 blockade in KRAS-mutant myeloid malignancies. Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.
         datePublished:2020-04-03T00:00:00Z
         dateModified:2020-04-03T00:00:00Z
         pageStart:1
         pageEnd:17
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1038/s41467-020-15497-1
         keywords:
            Bone marrow transplantation
            Myeloproliferative disease
            NOD-like receptors
            Targeted therapies
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig5_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig6_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig7_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig8_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig9_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig10_HTML.png
         isPartOf:
            name:Nature Communications
            issn:
               2041-1723
            volumeNumber:11
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Shaima’a Hamarsheh
               url:http://orcid.org/0000-0003-3991-5542
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Lena Osswald
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Benedikt S. Saller
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Susanne Unger
               affiliation:
                     name:University of Zurich
                     address:
                        name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Donatella De Feo
               affiliation:
                     name:University of Zurich
                     address:
                        name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Janaki Manoja Vinnakota
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Martina Konantz
               affiliation:
                     name:University of Basel and University Hospital Basel
                     address:
                        name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Franziska M. Uhl
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Heiko Becker
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Michael Lübbert
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Khalid Shoumariyeh
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christoph Schürch
               affiliation:
                     name:University of Basel and University Hospital Basel
                     address:
                        name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Geoffroy Andrieux
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Nils Venhoff
               affiliation:
                     name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Annette Schmitt-Graeff
               affiliation:
                     name:University of Freiburg
                     address:
                        name:University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Sandra Duquesne
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Dietmar Pfeifer
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Matthew A. Cooper
               url:http://orcid.org/0000-0003-3147-3460
               affiliation:
                     name:University of Queensland
                     address:
                        name:Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Claudia Lengerke
               url:http://orcid.org/0000-0001-5442-2805
               affiliation:
                     name:University of Basel and University Hospital Basel
                     address:
                        name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Melanie Boerries
               affiliation:
                     name:University of Freiburg
                     address:
                        name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Justus Duyster
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Charlotte M. Niemeyer
               affiliation:
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Miriam Erlacher
               url:http://orcid.org/0000-0002-7261-1447
               affiliation:
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Bruce R. Blazar
               affiliation:
                     name:University of Minnesota
                     address:
                        name:Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Burkard Becher
               url:http://orcid.org/0000-0002-1541-7867
               affiliation:
                     name:University of Zurich
                     address:
                        name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Olaf Groß
               affiliation:
                     name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Tilman Brummer
               affiliation:
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Robert Zeiser
               affiliation:
                     name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                     address:
                        name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:German Cancer Research Center (DKFZ)
                     address:
                        name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
                     name:University of Freiburg
                     address:
                        name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
      description:Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3 inflammasome activation in murine and human cells. Mice expressing active KrasG12D in the hematopoietic system developed myeloproliferation and cytopenia, which is reversed in KrasG12D mice lacking NLRP3 in the hematopoietic system. Therapeutic IL-1-receptor blockade or NLRP3-inhibition reduces myeloproliferation and improves hematopoiesis. Mechanistically, KrasG12D-RAC1 activation induces reactive oxygen species (ROS) production causing NLRP3 inflammasome-activation. In agreement with our observations in mice, patient-derived myeloid leukemia cells exhibit KRAS/RAC1/ROS/NLRP3/IL-1β axis activity. Our findings indicate that oncogenic KRAS not only act via its canonical oncogenic driver function, but also enhances the activation of the pro-inflammatory RAC1/ROS/NLRP3/IL-1β axis. This paves the way for a therapeutic approach based on immune modulation via NLRP3 blockade in KRAS-mutant myeloid malignancies. Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3 blockade.
      datePublished:2020-04-03T00:00:00Z
      dateModified:2020-04-03T00:00:00Z
      pageStart:1
      pageEnd:17
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1038/s41467-020-15497-1
      keywords:
         Bone marrow transplantation
         Myeloproliferative disease
         NOD-like receptors
         Targeted therapies
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig5_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig6_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig7_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig8_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig9_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1038%2Fs41467-020-15497-1/MediaObjects/41467_2020_15497_Fig10_HTML.png
      isPartOf:
         name:Nature Communications
         issn:
            2041-1723
         volumeNumber:11
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Shaima’a Hamarsheh
            url:http://orcid.org/0000-0003-3991-5542
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Lena Osswald
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Benedikt S. Saller
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Susanne Unger
            affiliation:
                  name:University of Zurich
                  address:
                     name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Donatella De Feo
            affiliation:
                  name:University of Zurich
                  address:
                     name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Janaki Manoja Vinnakota
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Martina Konantz
            affiliation:
                  name:University of Basel and University Hospital Basel
                  address:
                     name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Franziska M. Uhl
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Faculty of Biology, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Heiko Becker
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Michael Lübbert
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Khalid Shoumariyeh
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christoph Schürch
            affiliation:
                  name:University of Basel and University Hospital Basel
                  address:
                     name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Geoffroy Andrieux
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Nils Venhoff
            affiliation:
                  name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Annette Schmitt-Graeff
            affiliation:
                  name:University of Freiburg
                  address:
                     name:University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Sandra Duquesne
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Dietmar Pfeifer
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Matthew A. Cooper
            url:http://orcid.org/0000-0003-3147-3460
            affiliation:
                  name:University of Queensland
                  address:
                     name:Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Claudia Lengerke
            url:http://orcid.org/0000-0001-5442-2805
            affiliation:
                  name:University of Basel and University Hospital Basel
                  address:
                     name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Melanie Boerries
            affiliation:
                  name:University of Freiburg
                  address:
                     name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Justus Duyster
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Charlotte M. Niemeyer
            affiliation:
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Miriam Erlacher
            url:http://orcid.org/0000-0002-7261-1447
            affiliation:
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Bruce R. Blazar
            affiliation:
                  name:University of Minnesota
                  address:
                     name:Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Burkard Becher
            url:http://orcid.org/0000-0002-1541-7867
            affiliation:
                  name:University of Zurich
                  address:
                     name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Olaf Groß
            affiliation:
                  name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Tilman Brummer
            affiliation:
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Robert Zeiser
            affiliation:
                  name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
                  address:
                     name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:German Cancer Research Center (DKFZ)
                  address:
                     name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
                  name:University of Freiburg
                  address:
                     name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Nature Communications
      issn:
         2041-1723
      volumeNumber:11
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Faculty of Biology, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Faculty of Biology, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Zurich
      address:
         name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University of Zurich
      address:
         name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Faculty of Biology, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Basel and University Hospital Basel
      address:
         name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Faculty of Biology, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Basel and University Hospital Basel
      address:
         name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Queensland
      address:
         name:Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
         type:PostalAddress
      name:University of Basel and University Hospital Basel
      address:
         name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Minnesota
      address:
         name:Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, USA
         type:PostalAddress
      name:University of Zurich
      address:
         name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
         type:PostalAddress
      name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
      address:
         name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:German Cancer Research Center (DKFZ)
      address:
         name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
         type:PostalAddress
      name:University of Freiburg
      address:
         name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Shaima’a Hamarsheh
      url:http://orcid.org/0000-0003-3991-5542
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Faculty of Biology, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Lena Osswald
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Benedikt S. Saller
      affiliation:
            name:University of Freiburg
            address:
               name:Faculty of Biology, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Susanne Unger
      affiliation:
            name:University of Zurich
            address:
               name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Donatella De Feo
      affiliation:
            name:University of Zurich
            address:
               name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Janaki Manoja Vinnakota
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Faculty of Biology, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Martina Konantz
      affiliation:
            name:University of Basel and University Hospital Basel
            address:
               name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
               type:PostalAddress
            type:Organization
      name:Franziska M. Uhl
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Faculty of Biology, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Heiko Becker
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Michael Lübbert
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Khalid Shoumariyeh
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Christoph Schürch
      affiliation:
            name:University of Basel and University Hospital Basel
            address:
               name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
               type:PostalAddress
            type:Organization
      name:Geoffroy Andrieux
      affiliation:
            name:University of Freiburg
            address:
               name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Nils Venhoff
      affiliation:
            name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Annette Schmitt-Graeff
      affiliation:
            name:University of Freiburg
            address:
               name:University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Sandra Duquesne
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Dietmar Pfeifer
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Matthew A. Cooper
      url:http://orcid.org/0000-0003-3147-3460
      affiliation:
            name:University of Queensland
            address:
               name:Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
               type:PostalAddress
            type:Organization
      name:Claudia Lengerke
      url:http://orcid.org/0000-0001-5442-2805
      affiliation:
            name:University of Basel and University Hospital Basel
            address:
               name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
               type:PostalAddress
            type:Organization
      name:Melanie Boerries
      affiliation:
            name:University of Freiburg
            address:
               name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Justus Duyster
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Charlotte M. Niemeyer
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Miriam Erlacher
      url:http://orcid.org/0000-0002-7261-1447
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Bruce R. Blazar
      affiliation:
            name:University of Minnesota
            address:
               name:Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Burkard Becher
      url:http://orcid.org/0000-0002-1541-7867
      affiliation:
            name:University of Zurich
            address:
               name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
               type:PostalAddress
            type:Organization
      name:Olaf Groß
      affiliation:
            name:University Medical Center Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Tilman Brummer
      affiliation:
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      name:Robert Zeiser
      affiliation:
            name:Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
            address:
               name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:German Cancer Research Center (DKFZ)
            address:
               name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
            name:University of Freiburg
            address:
               name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Faculty of Biology, University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Faculty of Biology, University of Freiburg, Freiburg, Germany
      name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
      name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Faculty of Biology, University of Freiburg, Freiburg, Germany
      name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Faculty of Biology, University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
      name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
      name:Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland
      name:Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, USA
      name:Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
      name:Institute of Neuropathology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:Institute of Molecular Medicine and Cell Research (IMMZ), Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany
      name:Department of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
      name:German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany
      name:Comprehensive Cancer Centre Freiburg (CCCF), University of Freiburg, Freiburg, Germany
      name:Centre for Biological Signalling Studies (BIOSS) and Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany

External Links {🔗}(197)

Analytics and Tracking {📊}

  • Google Tag Manager

Libraries {📚}

  • Prism.js
  • Zoom.js

Emails and Hosting {✉️}

Mail Servers:

  • mxa-002c5801.gslb.pphosted.com
  • mxb-002c5801.gslb.pphosted.com

Name Servers:

  • pdns1.ultradns.net
  • pdns2.ultradns.net
  • pdns3.ultradns.org
  • pdns4.ultradns.org
  • pdns5.ultradns.info
  • pdns6.ultradns.co.uk

CDN Services {📦}

  • Crossref

5.78s.