
NATURE . COM {
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Title:
Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy | Nature Communications
Description:
Selective delivery of photosensitizers to mitochondria of cancer cells can enhance the efficacy of photodynamic therapy (PDT). Though cationic Ru-based photosensitizers accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application in PDT. We recently discovered X-ray based cancer therapy by nanoscale metal–organic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic therapy (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT. Constructed from Ru-based photosensitizers, the cationic framework exhibits strong mitochondria-targeting property. Upon X-ray irradiation, Hf-DBB-Ru efficiently generates hydroxyl radicals from the Hf6 SBUs and singlet oxygen from the DBB-Ru photosensitizers to lead to RT-RDT effects. Mitochondria-targeted RT-RDT depolarizes the mitochondrial membrane to initiate apoptosis of cancer cells, leading to significant regression of colorectal tumors in mouse models. Our work establishes an effective strategy to selectively target mitochondria with cationic nMOFs for enhanced cancer therapy via RT-RDT with low doses of deeply penetrating X-rays. Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.
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nature portfolio hf-dbb-ru-enabled mitochondria-targeted rt-rdt hf-dbb-ru enables rt-rdt metastasis research privacy policy hf-dbb-ru-enabled rt-rdt treatment olsalazine-based metal–organic frameworks hf-dbb-ru mediated rt-rdt hf-dbb-ru-treated group displayed hf-dbb-ru-enabled rt-rdt hf-dbb-ru-treated tumor slice hf-dbb-ru [dbb-ru = bis concave-shaped dose-response curves cationic nature hf-dbb-ru outperformed hf-dba 10-n-nonyl acridine orange advertising mitochondria-targeted radiotherapy-radiodynamic therapy toxic nature nanoscale metal–organic frameworks nanoscale metal-organic frameworks nanoscale metal–organic framework mitochondria-targeted rt-rdt depolarizes polydispersity index access mitochondrial genome nanoscale metal–organic layers �ray‐induced photodynamic therapy nature hf-dbb-ru group showed mitochondria-targeted rt-rdt treatment social media cationic hf-dbb-ru framework mitochondria-targeted ru-based pss hf-dbb-ru-treated group mitochondria-targeted hf-dbb-ru hf-dbb-ru treatment group photosensitizing metal-organic layers internalized hf-dbb-ru escaped reprints mitochondria-targeted triphenylphosphonium-based compounds hf-dbb-ru treatment led detecting phosphorylated γ-h2ax realize mitochondria-targeted therapy intravenously injected hf-dbb-ru japan hf-dbb-ru particles exhibited process termed rt-rdt35 biotin-conjugated anti-cox-2 antibody hf-dbb-ru-treated cells light‐triggered theranostics based
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headline:Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
description:Selective delivery of photosensitizers to mitochondria of cancer cells can enhance the efficacy of photodynamic therapy (PDT). Though cationic Ru-based photosensitizers accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application in PDT. We recently discovered X-ray based cancer therapy by nanoscale metalâorganic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic therapy (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT. Constructed from Ru-based photosensitizers, the cationic framework exhibits strong mitochondria-targeting property. Upon X-ray irradiation, Hf-DBB-Ru efficiently generates hydroxyl radicals from the Hf6 SBUs and singlet oxygen from the DBB-Ru photosensitizers to lead to RT-RDT effects. Mitochondria-targeted RT-RDT depolarizes the mitochondrial membrane to initiate apoptosis of cancer cells, leading to significant regression of colorectal tumors in mouse models. Our work establishes an effective strategy to selectively target mitochondria with cationic nMOFs for enhanced cancer therapy via RT-RDT with low doses of deeply penetrating X-rays. Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.
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headline:Nanoscale metal-organic frameworks for mitochondria-targeted radiotherapy-radiodynamic therapy
description:Selective delivery of photosensitizers to mitochondria of cancer cells can enhance the efficacy of photodynamic therapy (PDT). Though cationic Ru-based photosensitizers accumulate in mitochondria, they require excitation with less penetrating short-wavelength photons, limiting their application in PDT. We recently discovered X-ray based cancer therapy by nanoscale metalâorganic frameworks (nMOFs) via enhancing radiotherapy (RT) and enabling radiodynamic therapy (RDT). Herein we report Hf-DBB-Ru as a mitochondria-targeted nMOF for RT-RDT. Constructed from Ru-based photosensitizers, the cationic framework exhibits strong mitochondria-targeting property. Upon X-ray irradiation, Hf-DBB-Ru efficiently generates hydroxyl radicals from the Hf6 SBUs and singlet oxygen from the DBB-Ru photosensitizers to lead to RT-RDT effects. Mitochondria-targeted RT-RDT depolarizes the mitochondrial membrane to initiate apoptosis of cancer cells, leading to significant regression of colorectal tumors in mouse models. Our work establishes an effective strategy to selectively target mitochondria with cationic nMOFs for enhanced cancer therapy via RT-RDT with low doses of deeply penetrating X-rays. Photosensitizers delivered to mitochondria of cancer cells can enhance photodynamic therapy. Here, the authors report mitochondria-targeted radiation therapy and radiodynamic therapy of colorectal cancer models with a cationic nanoscale metal-organic framework to overcome shallow light penetration of Ru-based photosensitizers.
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