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We are analyzing https://www.nature.com/articles/s41467-017-01490-8.

Title:
GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk | Nature Communications
Description:
Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases. Male pattern baldness (MBP) is a complex trait that has genetic associations. Here, Pirastu and colleagues perform a genome-wide association study to show 71 susceptibility loci associated with MBP — 30 of which are novel — and that these loci can explain 38% of heritability.
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Keywords {🔍}

data, loci, pubmed, snps, analysis, article, genes, supplementary, baldness, genetic, google, scholar, traits, pathways, association, cas, hair, study, nature, risk, locus, age, pathway, pattern, results, biobank, central, regression, mbp, heritability, significant, disease, gwas, genomewide, complex, diseases, snp, gene, male, scores, research, effect, score, health, wnt, chromosome, cases, tested, human, genet,

Topics {✒️}

supplementary data 13 summarises supplementary data 1 describes supplementary data 2 supplementary data 3 supplementary data 4 supplementary data 5 supplementary data 6 supplementary data 7 supplementary data 8 supplementary data 9 supplementary data 10 supplementary data 11 supplementary data 12 supplementary data 13 supplementary data 14 supplementary data 15 supplementary data 16 supplementary data 17 supplementary data 18 supplementary data 19 supplementary data 1 supplementary data 21 nature portfolio uk/wp-content/uploads/2014/04/ukbiobank_genotyping_qc_documentation-web original bgen files privacy policy open access resource uk/wp-content/uploads/2014/04/imputation_documentation_may2015 supplementary fig supplementary figs interpreting genome data advertising uk biobank data cis-eqtl data genetic data set genetic data sets individual data sets gene expression data merck/rosetta research laboratories townsend deprivation index north-east social media open-angle glaucoma genetic data personal data data set data sets large-scale genome-wide association tools reprints

Schema {🗺️}

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      headline:GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
      description:Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases. Male pattern baldness (MBP) is a complex trait that has genetic associations. Here, Pirastu and colleagues perform a genome-wide association study to show 71 susceptibility loci associated with MBP — 30 of which are novel — and that these loci can explain 38% of heritability.
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