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Title:
GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk | Nature Communications
Description:
Male pattern baldness (MPB) or androgenetic alopecia is one of the most common conditions affecting men, reaching a prevalence of ~50% by the age of 50; however, the known genes explain little of the heritability. Here, we present the results of a genome-wide association study including more than 70,000 men, identifying 71 independently replicated loci, of which 30 are novel. These loci explain 38% of the risk, suggesting that MPB is less genetically complex than other complex traits. We show that many of these loci contain genes that are relevant to the pathology and highlight pathways and functions underlying baldness. Finally, despite only showing genome-wide genetic correlation with height, pathway-specific genetic correlations are significant for traits including lifespan and cancer. Our study not only greatly increases the number of MPB loci, illuminating the genetic architecture, but also provides a new approach to disentangling the shared biological pathways underlying complex diseases. Male pattern baldness (MBP) is a complex trait that has genetic associations. Here, Pirastu and colleagues perform a genome-wide association study to show 71 susceptibility loci associated with MBP — 30 of which are novel — and that these loci can explain 38% of heritability.
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Keywords {🔍}
data, loci, pubmed, snps, analysis, article, genes, supplementary, baldness, genetic, google, scholar, traits, pathways, association, cas, hair, study, nature, risk, locus, age, pathway, pattern, results, biobank, central, regression, mbp, heritability, significant, disease, gwas, genomewide, complex, diseases, snp, gene, male, scores, research, effect, score, health, wnt, chromosome, cases, tested, human, genet,
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supplementary data 13 summarises supplementary data 1 describes supplementary data 2 supplementary data 3 supplementary data 4 supplementary data 5 supplementary data 6 supplementary data 7 supplementary data 8 supplementary data 9 supplementary data 10 supplementary data 11 supplementary data 12 supplementary data 13 supplementary data 14 supplementary data 15 supplementary data 16 supplementary data 17 supplementary data 18 supplementary data 19 supplementary data 1 supplementary data 21 nature portfolio uk/wp-content/uploads/2014/04/ukbiobank_genotyping_qc_documentation-web original bgen files privacy policy open access resource uk/wp-content/uploads/2014/04/imputation_documentation_may2015 supplementary fig supplementary figs interpreting genome data advertising uk biobank data cis-eqtl data genetic data set genetic data sets individual data sets gene expression data merck/rosetta research laboratories townsend deprivation index north-east social media open-angle glaucoma genetic data personal data data set data sets large-scale genome-wide association tools reprints
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headline:GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk
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url:http://orcid.org/0000-0002-5159-8802
affiliation:
name:University Medical Center
address:
name:Department of Genetics, University Medical Center, Gröningen, The Netherlands
type:PostalAddress
type:Organization
name:Kari E. North
affiliation:
name:University of North Carolina
address:
name:Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, USA
type:PostalAddress
type:Organization
name:Peter Kraft
affiliation:
name:Harvard T. H. Chan School of Public Health
address:
name:Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, USA
type:PostalAddress
type:Organization
name:Alanna C. Morrison
affiliation:
name:The University of Texas Health Science Center at Houston
address:
name:Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA
type:PostalAddress
type:Organization
name:Tõnu Esko
url:http://orcid.org/0000-0003-1982-6569
affiliation:
name:University of Tartu
address:
name:Estonian Genome Center, University of Tartu, Tartu, Estonia
type:PostalAddress
type:Organization
name:Broad Institute of Harvard and MIT
address:
name:Broad Institute of Harvard and MIT, Cambridge, USA
type:PostalAddress
type:Organization
name:James F. Wilson
url:http://orcid.org/0000-0001-5751-9178
affiliation:
name:Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
address:
name:Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
type:PostalAddress
type:Organization
name:University of Edinburgh, Western General Hospital
address:
name:MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
type:PostalAddress
type:Organization
PostalAddress:
name:Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA
name:Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, USA
name:Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:Department of Food Science and Biotechnology, Dongguk University, Goyang, South Korea
name:Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, USA
name:Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, USA
name:Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, USA
name:Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, USA
name:Channing Division of Network Medicine, Department of Medicine, Brigham and Womenâs Hospital and Harvard Medical School, Boston, USA
name:Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:Pharmatics Ltd., Edinburgh, Scotland
name:Department of Genetics, University Medical Center, Gröningen, The Netherlands
name:Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, USA
name:Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, USA
name:Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA
name:Estonian Genome Center, University of Tartu, Tartu, Estonia
name:Broad Institute of Harvard and MIT, Cambridge, USA
name:Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland
name:MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
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