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Chemokine and chemotactic signals in dendritic cell migration | Cellular & Molecular Immunology
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Dendritic cells (DCs) are professional antigen-presenting cells responsible for the activation of specific T-cell responses and for the development of immune tolerance. Immature DCs reside in peripheral tissues and specialize in antigen capture, whereas mature DCs reside mostly in the secondary lymphoid organs where they act as antigen-presenting cells. The correct localization of DCs is strictly regulated by a large variety of chemotactic and nonchemotactic signals that include bacterial products, DAMPs (danger-associated molecular patterns), complement proteins, lipids, and chemokines. These signals function both individually and in concert, generating a complex regulatory network. This network is regulated at multiple levels through different strategies, such as synergistic interactions, proteolytic processing, and the actions of atypical chemokine receptors. Understanding this complex scenario will help to clarify the role of DCs in different pathological conditions, such as autoimmune diseases and cancers and will uncover new molecular targets for therapeutic interventions.
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nature portfolio permissions reprints research institute privacy policy advertising nature 392 nature 498 nature 449 nature social media monocyte-derived dendritic cells intracellular cell-related genes xcr1-expressing dendritic cells ccr9 + plasmacytoid dendritic cells cxcr2-dependent neutrophil recruitment xcr1-xcl1 chemokine axis ifn-producing cells respond chemokine-guided cell positioning cxcr5-expressing dendritic cells drive anti-tumor responses enable ccr7-dependent trafficking t-helper type-1 response specific t-cell responses francesca sozio & silvano sozzani human psoriatic lesions generating t-cell responses personal data superior antigen cross-presentation human monocyte-derived cxcr4-mediated signaling promote central tolerance mouse cd8 + dendritic cells antigen-presenting cell function author correspondence dendritic cell development springerlink instant access skin requires docking data protection naturally occurring cc-chemokines permissions dendritic cell biology monocyte-derived immature thymic dendritic cells bone marrow plasmacytoid dendritic cells chemokine receptor xcr1 annalisa del prete human dendritic cells cytokine growth factor haptotactic chemokine gradients
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headline:Chemokine and chemotactic signals in dendritic cell migration
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