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We are analyzing https://www.nature.com/articles/s41419-020-03268-1.

Title:
RNA-binding protein SORBS2 suppresses clear cell renal cell carcinoma metastasis by enhancing MTUS1 mRNA stability | Cell Death & Disease
Description:
RNA-binding proteins (RBPs) predominantly contribute to abnormal posttranscriptional gene modulation and disease progression in cancer. Sorbin and SH3 domain-containing 2 (SORBS2), an RBP, has been reported to be a potent tumor suppressor in several cancer types. Through integrative analysis of clinical specimens, we disclosed that the expression level of SORBS2 was saliently decreased in metastatic tissues and positively correlated with overall survival. We observed that overexpression of SORBS2 brought about decreased metastatic capacity in ccRCC cell lines. Transcriptome-wide analysis revealed that SORBS2 notably increased microtubule-associated tumor-suppressor 1 gene (MTUS1) expression. In-depth mechanistic exploring discovered that the Cys2-His2 zinc finger (C2H2-ZnF) domain of SORBS2 directly bound to the 3′ untranslated region (3′UTR) of MTUS1 mRNA, which increased MTUS1 mRNA stability. In addition, we identified that MTUS1 regulated microtubule dynamics via promoting KIF2CS192 phosphorylation by Aurora B. Together, our research identified SORBS2 as a suppressor of ccRCC metastasis by enhancing MTUS1 mRNA stability, providing a novel understanding of RBPs during ccRCC progression.
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30 years and 10 months (reg. 1994-08-11).

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Keywords {🔍}

cell, sorbs, mtus, pubmed, google, scholar, cancer, metastasis, ccrcc, mrna, cas, protein, expression, fig, tissues, analysis, lines, microtubule, metastatic, rna, carcinoma, cells, assay, central, nature, renal, tumor, article, performed, binding, data, patients, migration, stability, gene, domain, utr, western, blot, proteins, survival, dynamics, phosphorylation, qrtpcr, rnabinding, invasion, table, knockdown, aurora, kifc,

Topics {✒️}

nature portfolio research identified sorbs2 privacy policy gradient ethanol solutions c-abl-erk signaling pathway 2 μci/μl [γ-32p]-atp von hippel-lindau protein nature 499 nature advertising f-actin-rich membrane protrusions sample-wise mrna–protein correlation social media reprints renal cell carcinoma genome-wide experimental datasets znf384 mediates krt23 sorbs2-meidated metastasis suppression cys2-his2 zinc finger table s3 rna-binding protein hur 3′-utr-mediated post-transcriptional regulation table s2 rbp-mediated regulatory programs cancer development dual-luciferase reporter assay comprehensive molecular characterization potent microtubule-stabilizing protein19 sorbs2-overexpression cell lines rna libraries cell death dis library quality horseradish peroxidase-linked antibody c2h2-znf proteins comprise protein-protein association networks tubulin post-translational modifications cancer genome atlas kaplan–meier survival analysis human hepatocellular carcinoma figure 1a showed figure 4a showed regulates glioma sensitivity potential sorbs2-bound genes table s1 step rt-pcr system intermediate c2h2-znf domain figure 3e revealed permissions c-terminal sh3 domains quantitative real-time pcr

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