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psk, cells, phosphorylation, bms, mek, igfr, akt, fig, inhibition, cell, treated, pubmed, cancer, pdcd, activation, google, scholar, inhibitor, tumor, cas, colon, translation, data, protein, treatment, increased, knockdown, shown, hct, growth, survival, activity, mice, osi, analyzed, mrna, kinase, erk, significantly, western, central, resistance, independent, nature, levels, blot, images, induces, proliferation, inhibitors,

Topics {✒️}

nature portfolio privacy policy nature advertising social media dual igf-ir/ir inhibitor a-raf-related protein phosphorylation reprints p70 s6-kinase mediates igf-1r-mediated activation real-time quantitative pcr igf-1r governs pi3k/akt igf-1r signaling pathway targeting igf-1r appears artificial stem-loop structure hsin-sheng yang overcoming igf1r/ir resistance potent igf-1r inhibitor igf-1r/ir inhibitor full size image igf-ir null cells growth factor-1r/ir anti-igf-1r agents represses p53-dependent apoptosis phospho-s6 ribosomal protein antibodies targeting igf-1r markey cancer center author correspondence original author permissions phospho-p-70s6k1/gapdh igf-1r expression levels colon cancer therapy ras/erk signaling pathways ribosome-bound rnas igf-1r inhibition results inhibits pro-apoptotic proteins stress-induced kinases inhibits p53-dependent apoptosis pathogen-free conditions bms-754807-induced p70s6k1 activation dead box helicases kras mutation testing krasg12c inhibitors mediated china authors china academy development promotes cell death pro-apoptotic molecule bad ribosomal protein s6

Questions {❓}

• How does MEK activate AKT?
• If it is through IGF-1R inhibition, what is the molecular mechanism to induce p70S6K1 activation?

Schema {🗺️}

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