NATURE . COM {}

Matching Content Categories {📚}

• Education
• Social Networks
• Telecommunications

Content Management System {📝}

What CMS is nature.com built with?

Custom-built

No common CMS systems were detected on Nature.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of nature.com audience?

🌆 Monumental Traffic: 20M - 50M visitors per month


Based on our best estimate, this website will receive around 42,554,915 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Nature.com Make Money? {💸}

Display Ads {🎯}

Direct Advertisers (10)

Reseller Advertisers (38)

How Much Does Nature.com Make? {💰}

Display Ads {🎯}

$536,300 per month
Estimations show Nature.com's display ad online revenue falls between $357,503 and $983,134 per month.

Keywords {🔍}

article, nature, google, scholar, cas, bcr, access, ads, content, gene, chromosome, cookies, data, heisterkamp, groffen, privacy, translocation, human, cml, oncogene, cell, open, journal, leukaemia, chronic, region, abl, sequences, cdna, bcrabl, mrna, research, advertising, information, subscribe, june, role, stam, klein, cabl, breakpoint, phpositive, chimaeric, institution, buy, myeloid, science, usa, permissions, leukemia,

Topics {✒️}

nature portfolio permissions reprints privacy policy crispr/cas9-mediated double cleavages scientific excellence serve advertising social media subscribe nature ph′-positive patients examined nature 243 nature 300 nature 306 nature 315 nature 304 nature 5′ v-abl-homologous exon3 abl cellular proto-oncogene ph′-positive cml patients hsa-mir-181a-5p hsa-mir-26a-5p chronic myelocytic leukaemia human c-abl oncogene springerlink instant access permissions chimaeric bcr/abl mrna european economic area molecular mechanisms involved personal data hsa-mir-182-5p c-abl oncogene privacy data protection data suggest abl sequences confirms explore content subscription content bcr-abl protein protein-encoding regions complementary dna sequences institutional subscriptions read tyrosine kinase inhibitors hematological malignancies chris periventricular nodular heterotopia human leukaemia accepting optional cookies gene fusions elspeth journals search log bcr cdna sequences article heisterkamp normal ‘bcr gene

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Structural organization of the bcr gene and its role in the Ph′ translocation
         description:The Philadelphia (Ph′) chromosome, an abnormal chromosome 22 (ref. 1), is one of the best-known examples of a specific human chromosomal abnormality strongly associated with one form of human leukaemia, chronic myelocytic leukaemia (CML). The finding2 that a small region of chromosome 9 which includes the c-abl oncogene is translocated to chromosome 22 prompted studies to elucidate the molecular mechanisms involved in this disease. We have demonstrated previously that the chromosome 9 of one patient with CML contains a breakpoint 14 kilobases (kb) 5′ of the most 5′ v-abl-homologous exon3. These data suggest a role for c-abl in CML, a theory supported by the presence of an abnormally sized abl messenger RNA4,5 and protein6 in the CML cell line K562. The region involved in the translocation on chromosome 22 has also been identified: all Ph′-positive patients examined to date have a breakpoint within a 5.8-kb region, for which we have proposed the name ‘breakpoint cluster region’ (bcr)7. To determine whether her contains protein-encoding regions, probes from bcr were tested for their ability to hybridize to complementary DNA sequences. A 0.6-kb HindIII/BamHl bcr restriction enzyme fragment proved suitable for isolating several cDNA clones from a human fibroblast cDNA library8. Using bcr cDNA sequences, we obtained data strongly suggesting the presence of a chimaeric bcr/abl mRNA in the leukaemic cells of Ph′-positive CML patients. The recent isolation of cDNA clones containing bcr and abl sequences confirms this finding12. Because the bcr part of the chimaeric mRNA could be required to induce the transforming activity of the human c-abl oncogene, we have now initiated studies to characterize the normal ‘bcr gene’ and to determine the effect of a translocation within its coding domain. We demonstrate that as a result of the Ph′ translocation, a variable number of bcr exons are included in the chimaeric bcr/abl mRNA. The bcr gene sequences in this mRNA could be responsible for the transition of the abl cellular proto-oncogene into an oncogene.
         datePublished:1985-06-01T00:00:00Z
         dateModified:1985-06-01T00:00:00Z
         pageStart:758
         pageEnd:761
         sameAs:https://doi.org/10.1038/315758a0
         keywords:
            Science
            Humanities and Social Sciences
            multidisciplinary
         image:
         isPartOf:
            name:Nature
            issn:
               1476-4687
               0028-0836
            volumeNumber:315
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Nature Publishing Group UK
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Nora Heisterkamp
               affiliation:
                     name:Oncogene Science, Inc.
                     address:
                        name:Oncogene Science, Inc., Mineola, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kees Stam
               affiliation:
                     name:Oncogene Science, Inc.
                     address:
                        name:Oncogene Science, Inc., Mineola, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:John Groffen
               affiliation:
                     name:Oncogene Science, Inc.
                     address:
                        name:Oncogene Science, Inc., Mineola, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Annelies de Klein
               affiliation:
                     name:Erasmus University
                     address:
                        name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Gerard Grosveld
               affiliation:
                     name:Erasmus University
                     address:
                        name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Structural organization of the bcr gene and its role in the Ph′ translocation
      description:The Philadelphia (Ph′) chromosome, an abnormal chromosome 22 (ref. 1), is one of the best-known examples of a specific human chromosomal abnormality strongly associated with one form of human leukaemia, chronic myelocytic leukaemia (CML). The finding2 that a small region of chromosome 9 which includes the c-abl oncogene is translocated to chromosome 22 prompted studies to elucidate the molecular mechanisms involved in this disease. We have demonstrated previously that the chromosome 9 of one patient with CML contains a breakpoint 14 kilobases (kb) 5′ of the most 5′ v-abl-homologous exon3. These data suggest a role for c-abl in CML, a theory supported by the presence of an abnormally sized abl messenger RNA4,5 and protein6 in the CML cell line K562. The region involved in the translocation on chromosome 22 has also been identified: all Ph′-positive patients examined to date have a breakpoint within a 5.8-kb region, for which we have proposed the name ‘breakpoint cluster region’ (bcr)7. To determine whether her contains protein-encoding regions, probes from bcr were tested for their ability to hybridize to complementary DNA sequences. A 0.6-kb HindIII/BamHl bcr restriction enzyme fragment proved suitable for isolating several cDNA clones from a human fibroblast cDNA library8. Using bcr cDNA sequences, we obtained data strongly suggesting the presence of a chimaeric bcr/abl mRNA in the leukaemic cells of Ph′-positive CML patients. The recent isolation of cDNA clones containing bcr and abl sequences confirms this finding12. Because the bcr part of the chimaeric mRNA could be required to induce the transforming activity of the human c-abl oncogene, we have now initiated studies to characterize the normal ‘bcr gene’ and to determine the effect of a translocation within its coding domain. We demonstrate that as a result of the Ph′ translocation, a variable number of bcr exons are included in the chimaeric bcr/abl mRNA. The bcr gene sequences in this mRNA could be responsible for the transition of the abl cellular proto-oncogene into an oncogene.
      datePublished:1985-06-01T00:00:00Z
      dateModified:1985-06-01T00:00:00Z
      pageStart:758
      pageEnd:761
      sameAs:https://doi.org/10.1038/315758a0
      keywords:
         Science
         Humanities and Social Sciences
         multidisciplinary
      image:
      isPartOf:
         name:Nature
         issn:
            1476-4687
            0028-0836
         volumeNumber:315
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Nature Publishing Group UK
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Nora Heisterkamp
            affiliation:
                  name:Oncogene Science, Inc.
                  address:
                     name:Oncogene Science, Inc., Mineola, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kees Stam
            affiliation:
                  name:Oncogene Science, Inc.
                  address:
                     name:Oncogene Science, Inc., Mineola, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:John Groffen
            affiliation:
                  name:Oncogene Science, Inc.
                  address:
                     name:Oncogene Science, Inc., Mineola, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Annelies de Klein
            affiliation:
                  name:Erasmus University
                  address:
                     name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Gerard Grosveld
            affiliation:
                  name:Erasmus University
                  address:
                     name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Nature
      issn:
         1476-4687
         0028-0836
      volumeNumber:315
Organization:
      name:Nature Publishing Group UK
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Oncogene Science, Inc.
      address:
         name:Oncogene Science, Inc., Mineola, USA
         type:PostalAddress
      name:Oncogene Science, Inc.
      address:
         name:Oncogene Science, Inc., Mineola, USA
         type:PostalAddress
      name:Oncogene Science, Inc.
      address:
         name:Oncogene Science, Inc., Mineola, USA
         type:PostalAddress
      name:Erasmus University
      address:
         name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
         type:PostalAddress
      name:Erasmus University
      address:
         name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Nora Heisterkamp
      affiliation:
            name:Oncogene Science, Inc.
            address:
               name:Oncogene Science, Inc., Mineola, USA
               type:PostalAddress
            type:Organization
      name:Kees Stam
      affiliation:
            name:Oncogene Science, Inc.
            address:
               name:Oncogene Science, Inc., Mineola, USA
               type:PostalAddress
            type:Organization
      name:John Groffen
      affiliation:
            name:Oncogene Science, Inc.
            address:
               name:Oncogene Science, Inc., Mineola, USA
               type:PostalAddress
            type:Organization
      name:Annelies de Klein
      affiliation:
            name:Erasmus University
            address:
               name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
      name:Gerard Grosveld
      affiliation:
            name:Erasmus University
            address:
               name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Oncogene Science, Inc., Mineola, USA
      name:Oncogene Science, Inc., Mineola, USA
      name:Oncogene Science, Inc., Mineola, USA
      name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
      name:Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

Social Networks {👍}(2)

• https://www.facebook.com/Nature
• https://twitter.com/nature

External Links {🔗}(65)

• How much revenue does https://link.springer.com/article/10.1038/315758a0?utm_source=nature&utm_medium=referral&utm_campaign=buyArticle produce monthly?
• What's the profit of https://doi.org/10.1038%2F243290a0?
• What is the monthly revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1973Natur.243..290R?
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F243290a0&volume=243&pages=290-293&publication_year=1973&author=Rowley%2CJD pull in monthly?
• What's the income generated by https://doi.org/10.1038%2F300765a0 each month?
• What's the financial intake of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1982Natur.300..765K?
• Explore the financials of http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F300765a0&volume=300&pages=765-767&publication_year=1982&author=de%20Klein%2CA
• How much profit does https://doi.org/10.1038%2F306239a0 make?
• Income figures for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.306..239H
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F306239a0&volume=306&pages=239-242&publication_year=1983&author=Heisterkamp%2CN earn?
• https://doi.org/10.1126%2Fscience.6587568's revenue stream
• Profit of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1984Sci...225...72C
• What's the total monthly financial gain of http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.6587568&volume=225&pages=72-74&publication_year=1984&author=Collins%2CSJ&author=Kubonishi%2CI&author=Miyoshi%2CI&author=Groudine%2CMT?
• Profit of https://doi.org/10.1073%2Fpnas.81.18.5648
• How profitable is http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1984PNAS...81.5648G?
• What's the financial gain of http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.81.18.5648&volume=81&pages=5648-5652&publication_year=1984&author=Gale%2CRP&author=Canaani%2CE?
• How profitable is https://doi.org/10.1016%2F0092-8674%2884%2990438-0?
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2884%2990438-0&volume=317&pages=1035-1042&publication_year=1984&author=Konopka%2CJB&author=Watanabe%2CSM&author=Witte%2CON have monthly?
• What's the financial gain of https://doi.org/10.1016%2F0092-8674%2884%2990077-1?
• What's the financial intake of http://scholar.google.com/scholar_lookup?&title=&journal=Cell&doi=10.1016%2F0092-8674%2884%2990077-1&volume=36&pages=93-99&publication_year=1984&author=Groffen%2CJ?
• Revenue of https://doi.org/10.1128%2FMCB.3.2.280
• How much cash flow does http://scholar.google.com/scholar_lookup?&title=&journal=Molec.%20Cell%20Biol.&doi=10.1128%2FMCB.3.2.280&volume=3&pages=280-289&publication_year=1983&author=Okayama%2CH&author=Berg%2CP have monthly?
• Find out how much https://doi.org/10.1038%2F306277a0 earns monthly
• What are the total earnings of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.306..277B?
• See how much http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F306277a0&volume=306&pages=277-280&publication_year=1983&author=Bartram%2CCR makes per month
• How much cash flow does https://doi.org/10.1126%2Fscience.2983426 have monthly?
• Revenue of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Sci...227.1435L
• How much does http://scholar.google.com/scholar_lookup?&title=&journal=Science&doi=10.1126%2Fscience.2983426&volume=227&pages=1435-1441&publication_year=1985&author=Lipman%2CDF&author=Pearson%2CWR make?
• Learn about the earnings of https://doi.org/10.1002%2Fj.1460-2075.1985.tb03683.x
• How much money does http://scholar.google.com/scholar_lookup?&title=&journal=EMBO%20J.&doi=10.1002%2Fj.1460-2075.1985.tb03683.x&volume=4&pages=683-686&publication_year=1985&author=Bartram%2CCR generate?
• What is the earnings of https://doi.org/10.1038%2F315550a0?
• How much does http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Natur.315..550S rake in every month?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F315550a0&volume=315&pages=550-554&publication_year=1985&author=Canaani%2CE generate?
• How much profit does https://doi.org/10.1038%2F304167a0 generate?
• What's the monthly income of http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1983Natur.304..167G?
• What is the monthly revenue of http://scholar.google.com/scholar_lookup?&title=&journal=Nature&doi=10.1038%2F304167a0&volume=304&pages=167-169&publication_year=1983&author=Groffen%2CJ&author=Heisterkamp%2CN&author=Reynolds%2CF&author=Stephenson%2CJR?
• How profitable is https://doi.org/10.1073%2Fpnas.74.12.5463?
• What's the revenue for http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1977PNAS...74.5463S?
• How much income does http://scholar.google.com/scholar_lookup?&title=&journal=Proc.%20natn.%20Acad.%20Sci.%20U.S.A.&doi=10.1073%2Fpnas.74.12.5463&volume=74&pages=5463-5467&publication_year=1977&author=Sanger%2CF&author=Nicklen%2CS&author=Coulson%2CAR have?
• What's the financial outcome of https://doi.org/10.1016%2F0378-1119%2882%2990016-6?
• How much revenue does http://scholar.google.com/scholar_lookup?&title=&journal=Gene&doi=10.1016%2F0378-1119%2882%2990016-6&volume=19&pages=269-276&publication_year=1982&author=Messing%2CJ&author=Vieira%2CJ generate?
• How much money does https://doi.org/10.1016%2F0042-6822%2883%2990473-7 generate?
• Monthly income for http://scholar.google.com/scholar_lookup?&title=&journal=Virology&doi=10.1016%2F0042-6822%2883%2990473-7&volume=126&pages=213-227&publication_year=1983&author=Groffen%2CJ&author=Heisterkamp%2CN&author=Blennerhassett%2CG&author=Stephenson%2CJR
• How much revenue does https://citation-needed.springer.com/v2/references/10.1038/315758a0?format=refman&flavour=references produce monthly?
• Revenue of https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Nora%20Heisterkamp
• Get to know https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Nora%20Heisterkamp%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en's earnings
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Kees%20Stam generate monthly?
• How much does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Kees%20Stam%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=John%20Groffen rake in every month?
• How much cash flow does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22John%20Groffen%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en have monthly?
• How much revenue does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Annelies%20de%20Klein bring in?
• How much profit does https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Annelies%20de%20Klein%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en make?
• How much does https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Gerard%20Grosveld earn?
• What's the financial gain of https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Gerard%20Grosveld%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en?
• How much does https://s100.copyright.com/AppDispatchServlet?title=Structural%20organization%20of%20the%20bcr%20gene%20and%20its%20role%20in%20the%20Ph%E2%80%B2%20translocation&author=Nora%20Heisterkamp%20et%20al&contentID=10.1038%2F315758a0©right=Springer%20Nature%20Limited&publication=0028-0836&publicationDate=1985-06-01&publisherName=SpringerNature&orderBeanReset=true generate monthly?
• How much does https://citation-needed.springer.com/v2/references/10.1038/315758a0?format=refman&flavour=citation pull in monthly?
• What's the profit of https://doi.org/10.1186/s12885-022-09396-5?
• How much profit does https://doi.org/10.1038/s41408-022-00738-x make?
• What is the earnings of https://doi.org/10.1038/s41375-021-01436-6?
• Financial intake of https://doi.org/10.1038/s41388-020-1253-0
• What's the income of https://doi.org/10.1038/s41431-019-0335-3?
• How much does https://www.protocols.io/ rake in every month?
• https://www.natureindex.com/ income
• What's the monthly money flow for http://www.naturechina.com?
• Find out how much https://www.natureasia.com/ja-jp earns monthly

Analytics and Tracking {📊}

• Google Tag Manager

Libraries {📚}

• Prism.js
• Zoom.js

Emails and Hosting {✉️}

Mail Servers:

• mxa-002c5801.gslb.pphosted.com
• mxb-002c5801.gslb.pphosted.com

Name Servers:

• pdns1.ultradns.net
• pdns2.ultradns.net
• pdns3.ultradns.org
• pdns4.ultradns.org
• pdns5.ultradns.info
• pdns6.ultradns.co.uk

CDN Services {📦}

• Crossref