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Title:
The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
Description:
The ubiquitin-proteasome system is responsible for the degradation of most intracellular proteins, including those that control cell cycle progression, apoptosis, signal transduction and the NF-ΞΊB transcriptional pathway. Aberrations in the ubiquitin-proteasome system underlie the pathogenesis of many human diseases, so both the ubiquitin-conjugating system and the 20S proteasome are important targets for drug discovery. This article presents a few of the most important examples of the small molecule inhibitors and modulators targeting the ubiquitin-proteasome system, their mode of action, and their potential therapeutic relevance in the treatment of cancer and inflammatory-related diseases.
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Article:
author:
type:Person
name:Halina Ostrowska
editor:
audience:
datePublished:2008-09-01
headline:
keywords:keyword,keyword,keyword,keyword,keyword,keyword,keyword,keyword
isAccessibleForFree:1
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type:Organization
name:De Gruyter
context:https://schema.org
name:The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
image:https://www.degruyterbrill.com/document/cover/journal_key/CMBLE/thumbnail
url:https://doi.org/10.2478/s11658-008-0008-7
Person:
name:Halina Ostrowska
Organization:
name:De Gruyter
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