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Title:
Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection
Description:
Vancomycin Hydrochloride is an antibiotic produced by the growth of certain strains of Streptomyces orientalis. As Vancomycin Hydrochloride is poorly absorbed after oral administration; it is given intravenously for therapy of systemic infections. Vancomycin was labeled with technetium-99m pertechnetate using SnCl 2 ·2H 2 O as reducing agent. The labeling efficiency depends on ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99m Tc-Vancomycin was determined by thin layer chromatography. Biodistribution studies of 99m Tc-Vancomycin were performed in a model of bacterial infection in Sprague–Dawley rats. A significantly higher accumulation of 99m Tc-Vancomycin was seen at sites of S. aureus infected animals. Whereas uptake of 99m Tc-Vancomycin in turpentine inflamed rats were quite low.
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Keywords {🔍}
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Topics {✒️}
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Article:
author:
type:Person
name:Samina Roohi
type:Person
name:A. Mushtaq
type:Person
name:Salman A. Malik
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datePublished:2005-07-01
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type:Organization
name:De Gruyter (O)
context:https://schema.org
name:Synthesis and biodistribution of 99mTc-Vancomycin in a model of bacterial infection
image:https://www.degruyterbrill.com/document/cover/journal_key/RACT/thumbnail
url:https://doi.org/10.1524/ract.2005.93.7.415
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name:Samina Roohi
name:A. Mushtaq
name:Salman A. Malik
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name:De Gruyter (O)
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