DEGRUYTERBRILL . COM {
}
Title:
Mechanism of Carbon Tetrachloride-Induced Hepatotoxicity. Hepatocellular Damage by Reactive Carbon Tetrachloride Metabolites
Description:
CCl 4 -induced liver damage was modeled in monolayer cultures of rat primary hepatocytes with a focus on involvement of covalent binding of CCl 4 metabolites to cell components and/or peroxidative damage as the cause of injury. (1) Covalent binding of 14 C-labeled metabolites was detected in hepatocytes immediately after exposure to CCl 4 . (2) Low oxygen partial pressure increased the reductive metabolism of CCl 4 and thus covalent binding. (3) [ 14 C]-CCl 4 was bound to lipids and to proteins throughout subcellular fractions. Binding occurred preferentially to triacylglycerols and phospholipids, with phosphatidylcholine containing the highest amount of label. (4) The lipid peroxidation potency of CCl 4 revealed subtle differences compared to other peroxidative substances, viz., ADP-Fe 3+ and cumol hydroperoxide, respectively. (5) CCl 4 , but not the other peroxidative substances, decreased the rate of triacylglycerol secretion as very low density lipoproteins. (6) The anti-oxidant vitamin E (Ξ±-tocopherol) blocked lipid peroxidation, but not covalent binding, and secretion of lipoproteins remained inhibited. (7) The radical scavenger piperonyl butoxide prevented CCl 4 -induced lipid peroxidation as well as covalent bindΒing of CCI 4 metabolites to cell components, and also restored lipoprotein metabolism. The results confirm that covalent binding of the CCl 3 * radical to cell components initiates the inhibition of lipoprotein secretion and thus steatosis, whereas reaction with oxygen, to form CCI 3 *-OO*, initiates lipid peroxidation. The two processes are independent of each other, and the extent to which either process occurs depends on partial oxygen pressure. The former process may result in adduct formation and, ultimately, cancer initiation, whereas the latter results in loss of calcium homeostasis and, ultimately, apoptosis and cell death
Website Age:
1 years and 8 months (reg. 2023-10-11).
Matching Content Categories {π}
- Health & Fitness
- Insurance
- Science
Content Management System {π}
What CMS is degruyterbrill.com built with?
Custom-built
No common CMS systems were detected on Degruyterbrill.com, but we identified it was custom coded using Bootstrap (CSS).
Traffic Estimate {π}
What is the average monthly size of degruyterbrill.com audience?
π Monumental Traffic: 20M - 50M visitors per month
Based on our best estimate, this website will receive around 34,952,939 visitors per month in the current month.
check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush
How Does Degruyterbrill.com Make Money? {πΈ}
We find it hard to spot revenue streams.
Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Degruyterbrill.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.
Keywords {π}
carbon, search, mechanism, tetrachlorideinduced, hepatotoxicity, hepatocellular, damage, reactive, tetrachloride, metabolites, article, access, published, journal, membrane, content, author, gruyter, brill, zeitschrift, naturforschung, issue, species, responses, propolis, chemical, composition, insect, model, senex, fibres, policy, skip, main, authors, librarians, subjects, services, home, open, cite, meinrad, boll, lutz, eberhard, becker, andreas, stampfl, publishedcopyright, june,
Topics {βοΈ}
carbon tetrachloride-induced hepatotoxicity respiratory redox-cyclers enforced albania computer-aided design hydrocarbon enzyme-catalyzed decomposition man-made vitreous fibres search home mechanism newsletter institutional access tanacetum species growing dibucaine-induced modification insect growth regulator 1515/znc-2001-7-826 creative commons fern notholaena sulphurea scrophularia genus flavon achillea pannonica scheele cortex oleoresin variability abies alba mill pseudomonas aeruginosa grown organic solvents triaziflam steady state levels thylakoid membrane proteins cucumis sativus cotyledons hemolymph glucose level delayed apoptotic response conditions legal notice 2014 download article journal https Ξ²-dihydroagarofurans access work chemical composition privacy policy membrane derangement behavioral responses model membranes subjects services hepatocellular damage eberhard becker author 2001-3-28 published online diprenyl coumarin zanthoxylum dimorphophyllum polyene pigment melanogaster broomeianus taxonomic significance bulgaria iridoids silver fir pyridinochelin production peptidoglycolipid bioemulsifier dibenzoyl peroxide aristolochia aff orbicularis roots
Questions {β}
- Have an idea on how to improve our website?
- How does access work?
Schema {πΊοΈ}
Article:
author:
type:Person
name:Meinrad Boll
type:Person
name:W. D. Lutz
type:Person
name:Eberhard Becker
type:Person
name:Andreas Stampfl
editor:
audience:
datePublished:2001-08-01
headline:
keywords:
isAccessibleForFree:1
publisher:
type:Organization
name:De Gruyter
context:https://schema.org
name:Mechanism of Carbon Tetrachloride-Induced Hepatotoxicity. Hepatocellular Damage by Reactive Carbon Tetrachloride Metabolites
image:https://www.degruyterbrill.com/document/cover/journal_key/ZNC/thumbnail
url:https://doi.org/10.1515/znc-2001-7-826
Person:
name:Meinrad Boll
name:W. D. Lutz
name:Eberhard Becker
name:Andreas Stampfl
Organization:
name:De Gruyter
Social Networks {π}(4)
External Links {π}(9)
- How much revenue does https://blog.degruyter.com/ generate?
- What is the monthly revenue of https://scholar.google.com/scholar?as_q=&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Meinrad Boll%22&as_publication=&as_ylo=&as_yhi=&hl=en&as_sdt=0%2C5?
- https://scholar.google.com/scholar?as_q=&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22W. D. Lutz%22&as_publication=&as_ylo=&as_yhi=&hl=en&as_sdt=0%2C5's revenue stream
- Get to know what's the income of https://scholar.google.com/scholar?as_q=&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Eberhard Becker%22&as_publication=&as_ylo=&as_yhi=&hl=en&as_sdt=0%2C5
- What's the revenue for https://scholar.google.com/scholar?as_q=&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Andreas Stampfl%22&as_publication=&as_ylo=&as_yhi=&hl=en&as_sdt=0%2C5?
- Revenue of https://mc.manuscriptcentral.com/znc
- What are the total earnings of https://doi.org/10.1515/znc-2001-7-826?
- How much does https://creativecommons.org/licenses/by-nc-nd/3.0/ gross monthly?
- See how much https://bsky.app/profile/degruyterbrill.bsky.social makes per month
Analytics and Tracking {π}
- Google Analytics
- Google Tag Manager
Libraries {π}
- Bootstrap
- Clipboard.js
Emails and Hosting {βοΈ}
Mail Servers:
- degruyterbrill-com.mail.protection.outlook.com
Name Servers:
- ns-1335.awsdns-38.org
- ns-1776.awsdns-30.co.uk
- ns-379.awsdns-47.com
- ns-617.awsdns-13.net