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Title:
Exocyclic DNA Adducts as Oxidative Stress Markers in Colon Carcinogenesis: Potential Role of Lipid Peroxidation, Dietary Fat and Antioxidants
Description:
Molecular pathways to colorectal cancer involve multiple genetic changes, whereby extensive oxyradical damage causes mutations in cancerrelated genes and leads to a cycle of cell death and regeneration. Besides direct oxidative DNAdamage, reactive oxygen and nitrogen species can induce etheno ()DNA adducts mainly via trans-4-hydroxy-2-nonenal, generated as the major aldehyde by lipid peroxidation (LPO) of Ο-6 PUFAs. Patients with familial adenomatous polyposis (FAP) develop multiple colorectal adenomas. In affected tissues increased LPO could be triggered due to increased arachidonic acid metabolism as a result of elevated cyclooxygenases. Our studies demonstrated an increased DNA adduct level in affected colon epithelia of FAP patients. DNA adducts are promutagenic and can cause genomic instability that drives colorectal adenoma to malignancy. We have further investigated the potential chemopreventive properties of olive oil and its polyphenolic components. Mediterranean diet, of which olive oil is a major fatty acid source, has protective effects against human breast and colorectal cancers. Olive oil extracts and the newly identified lignan fractions showed high antioxidant capacity in vitro. As DNA adducts are biomarkers for oxidative stress and LPO induced DNA damage, they can verify the efficacy of newly identified antioxidants, e.g. from olive oil, as chemopreventive agents against colon carcinogenesis.
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Keywords {π}
dna, oxidative, colon, carcinogenesis, search, exocyclic, adducts, stress, markers, potential, role, lipid, peroxidation, dietary, fat, antioxidants, journal, human, protein, content, article, author, gruyter, brill, issue, repair, analysis, methylation, cancer, polymorphism, cathepsin, access, policy, skip, main, authors, librarians, subjects, services, home, cite, helmut, bartsch, jagadeesan, nair, robert, owen, publishedcopyright, june, published,
Topics {βοΈ}
exocyclic dna adducts dna repair glycosylases antioxidants dna polymorphisms cancer recent aspects oxidative dna damage human transferrin receptor oxidative stress markers antioxidants helmut bartsch yeast msh2-msh6 ceramide level alters conditions legal notice mammalian genomes methylation newsletter institutional access owen published/copyright journal https issue highlight dna methylation prion protein colon carcinogenesis privacy policy author access work subjects services potential role lipid peroxidation dietary fat jagadeesan nair homologous recombination rassf1a gene guanine lesions substrate specificity versatile modulator lysosomal targeting proteoliposomes processing distinct positions stalk region neutrophil elastase primates reveals discount subscribe main content polymorphism 2005 published content skip authors librarians robert june 1 subject //doi
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Article:
author:
type:Person
name:Helmut Bartsch
type:Person
name:Jagadeesan Nair
type:Person
name:Robert W. Owen
editor:
audience:
datePublished:2002-06-26
headline:
keywords:
isAccessibleForFree:
publisher:
type:Organization
name:De Gruyter
context:https://schema.org
name:Exocyclic DNA Adducts as Oxidative Stress Markers in Colon Carcinogenesis: Potential Role of Lipid Peroxidation, Dietary Fat and Antioxidants
image:https://www.degruyterbrill.com/document/cover/journal_key/BCHM/thumbnail
url:https://doi.org/10.1515/BC.2002.098
Person:
name:Helmut Bartsch
name:Jagadeesan Nair
name:Robert W. Owen
Organization:
name:De Gruyter
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