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We are analyzing https://www.biorxiv.org/content/10.1101/2025.06.23.660997v1.

Title:
MEGaNorm: Normative Modeling of MEG Brain Oscillations Across the Human Lifespan | bioRxiv
Description:
Normative modeling provides a principled framework for quantifying individual deviations from typical brain development and is increasingly used to study heterogeneity in neuropsychiatric conditions. While widely applied to structural phenotypes, functional normative models remain underdeveloped. Here, we introduce MEGaNorm, the first normative modeling framework for charting lifespan trajectories of resting-state magnetoencephalography (MEG) brain oscillations. Using a large, multi-site dataset comprising 1,846 individuals aged 6–88 and spanning three MEG systems, we model relative oscillatory power in canonical frequency bands using hierarchical Bayesian regression, accounting for age, sex, and site effects. To support interpretation at multiple scales, we introduce Neuro-Oscillo Charts, visual tools that summarize normative trajectories at the population level and quantify individual-level deviations, enabling personalized assessment of functional brain dynamics. Applying this framework to a Parkinson’s disease cohort (n = 160), we show that normative deviation scores reveal disease-related abnormalities and uncover a continuum of patients in theta–beta deviation space. This work provides the first lifespan-encompassing normative reference for MEG oscillations, enabling population-level characterization and individualized benchmarking. All models and tools are openly available and designed for federated, continual adaptation as new data become available, offering a scalable resource for precision neuropsychiatry. ### Competing Interest Statement The authors have declared no competing interest.
Website Age:
12 years and 2 months (reg. 2013-04-08).

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  • Education
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Website use Drupal 7 (http://drupal.org).

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💥 Very Strong Traffic: 200k - 500k visitors per month


Based on our best estimate, this website will receive around 261,717 visitors per month in the current month.

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How Does Biorxiv.org Make Money? {💸}

We can't figure out the monetization strategy.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Biorxiv.org could have a money-making trick up its sleeve, but it's undetectable for now.

Keywords {🔍}

view, orcid, profile, biology, normative, meg, brain, medrxiv, subject, reviews, clinical, preprint, modeling, oscillations, framework, tools, biorxiv, university, trials, epidemiology, search, results, meganorm, lifespan, pdf, abstract, deviations, functional, models, introduce, trajectories, systems, site, support, enabling, deviation, competing, interest, authors, copyright, license, institute, technology, cancer, neuroscience, context, genetics, microbiology, papers, submitted,

Topics {✒️}

epidemiology subject categories clinical trials theta–beta deviation space lifespan-encompassing normative reference introduce neuro-oscillo charts biorxiv subject category quantify individual-level deviations genetics microbiology enabling population-level characterization reviews epidemiology papers health-related information normative modeling framework charting lifespan trajectories summarize normative trajectories augustijn de boer author/funder keyword advanced search quantifying individual deviations data functional brain dynamics enabling personalized assessment visual tools resting-state magnetoencephalography canonical frequency bands hierarchical bayesian regression chan zuckerberg initiative imperial college london vrije universiteit amsterdam articles animal behavior normative modeling typical brain development generous financial support competing interest statement context tools meg brain oscillations disease cohort population level meg systems brain oscillations introduce meganorm competing interest support interpretation site effects meg oscillations results follow //doi principled framework

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Mail Servers:

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