PUBMED . NCBI . NLM . NIH . GOV {
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Title:
PRPF8 defects cause missplicing in myeloid malignancies - PubMed
Description:
Mutations of spliceosome components are common in myeloid neoplasms. One of the affected genes, PRPF8, encodes the most evolutionarily conserved spliceosomal protein. We identified either recurrent somatic PRPF8 mutations or hemizygous deletions in 15/447 and 24/450 cases, respectively. Fifty percen …
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Keywords {🔍}
prpf, doi, pmc, pmid, mutations, pubmed, splicing, myeloid, leukemia, epub, neoplasms, figure, free, article, nih, states, genes, gene, similar, articles, defects, review, hhsunited, main, ncbi, conflict, cited, references, mesh, resources, missplicing, protein, somatic, cases, cells, sequencing, cell, chen, aug, blood, hematologic, nature, sequence, rnabinding, proteins, hhs, page, content, homepage, navigation,
Topics {✒️}
united states government rna deep sequencing cell proliferation funding linkout rna splicing process hematologic malignancies main page content gene prpf8 knockdown leukemogenic gene hhs affect pre-mrna splicing dna sequencing myeloid neoplasms literature sources yeast saccharomyces cerevisiae resources leukemia similar articles cited chronic myelomonocytic leukemia aberrant alternative splicing extramural research support pubmed central male germ cells aberrant splicing alternative splicing primary cells somatic u2af1 mutations targeting splicing splicing machinery conveyed poor prognosis block experimentally produced proof-reading functions functional consequences suggests competing financial interests hypoxia-induced mitophagy natl cancer inst clin transl oncol strong heart study somatic sf3b1 mutation homologous mutations introduced frequent pathway mutations prpf8 defects correlated human services increased myeloblasts mclellan md affected genes prpf8 defects pubmed papaemmanuil pubmed wordmark pubmed logo
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