PMC . NCBI . NLM . NIH . GOV {
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We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC8448144/.
Title:
Epetraborole Is Active against Mycobacterium abscessus - PMC
Description:
Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Title:
Epetraborole Is Active against Mycobacterium abscessus - PMC
Description:
Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
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Keywords {🔍}
abscessus, doi, epetraborole, pmc, pubmed, google, scholar, clinical, article, resistance, mycobacterium, activity, free, subsp, leus, agents, active, antimicrob, chemother, aac, benzoxaborole, treatment, isolate, cfu, synthetase, discovery, fig, nlm, leucyltrna, infection, lung, tuberculosis, mic, strain, table, gramnegative, model, mice, day, ncbi, search, dick, reported, drug, leurs, bacteria, clarithromycin, zhang, alley, inhibitor,
Topics {✒️}
leucyl-trna synthetase inhibitor leucyl-trna synthetase inhibitors drug-free vehicle control target leucyl-trna synthetase broad-spectrum anti-mycobacterial activity pmc beta search 7-o-propanol substituent added nonfermentative gram-negative bacilli gram-negative bacterial species 300 mg/kg body weight showed high-level resistance drug-free vehicle aminoacyl-trna synthetase drug-free day 1 protein synthesis inhibitor publisher site pdf lung bacterial burden bacterial lung burden gram-negative infections license information pmcid advanced lead compounds blocking protein synthesis institutional animal care oxaborole trna-trapping improved antituberculosis activity benzoxaborole resistance emerging clinical candidate developed critical care medicine anti-gram-negative united states government middlebrook 7h9 medium lowest concentration suppressing nod scid mice including oral bioavailability daily oral administration yonsei university college award number r01ai132374 antibiotic-modifying enzymes del rio rg scangarella-oman ne hanh b-t benzoxaborole-based candidate national university hospital nonhalogenated benzoxaborole epetraborole abscessus lung disease apparent resistant colonies spontaneous resistance frequencies antibiotic-target-modifying gram-negative bacteria wild-type colonies
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