
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Targeting TGFβ signal transduction for cancer therapy - PMC
Description:
Transforming growth factor-β (TGFβ) family members are structurally and functionally related cytokines that have diverse effects on the regulation of cell fate during embryonic development and in the maintenance of adult tissue homeostasis. ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
Matching Content Categories {📚}
- Education
- Science
- Health & Fitness
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Custom-built
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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How Does Pmc.ncbi.nlm.nih.gov Make Money? {💸}
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Keywords {🔍}
doi, tgfβ, google, scholar, pubmed, cancer, pmc, article, free, cell, cells, tumor, growth, patients, nct, signaling, phase, combination, transforming, therapy, advanced, receptor, clinical, tumors, immune, protein, kinase, factor, study, biol, antitumor, activation, smad, inhibitor, monotherapy, breast, metastatic, factorβ, treatment, expression, solid, res, targeting, antibody, pathway, tβri, recruiting, completed, clin, latent,
Topics {✒️}
anti-transforming growth factor-β breast/lung/hepatocellular/colorectal/pancreatic/renal cancer overcome chemo/targeted/radio-therapy resistance tgf-β-induced epithelial–mesenchymal transition tgf-β-induced epithelial-mesenchymal transition tgf-β-mediated epithelial-mesenchymal transition recurrent/refractory high-grade glioma chimeric erythropoietin-tgf-β receptors transforming growth factor-β anti-pd-l1 antibody mpdl3280a tgf-β-induced foxp3 inhibits tgf-β-driven program transforming growth factor-β1 latent tgf-β1-binding protein cross-species single-cell analysis platelet-derived growth factor pan anti-tgfβ-neutralizing antibody pan-tgfβ ligand-neutralizing antibody transforming growth factor-β3 tgfβ-regulated mad-related protein anti-pd-1 immunotherapy-resistant tumors pd-l1-mediated signaling pathways target anti-tgf-β therapies triple-negative breast cancer receptor kinase-independent manner her2-negative breast cancer tgf-β utilizes smad3 anti-tgf-β2 antisense pd-l1 expressing advanced tgf-β1 receptor type phosphatidylinositol 3-kinase/akt-dependent pathway tgfβ/smad-induced target genes tgf-β-induced rhoa single-molecule force spectroscopy negatively regulates tgf-β tgf-β responsive signature acute myeloid leukemia ph-responsive clustered nanoparticles distinct tgf-β type cutaneous squamous-cell carcinomas tgf-β antibody uptake latent tgf-β structure α-smooth muscle actin c-myc gene transcription mitogen-activated protein kinase tgf-β orchestrates fibrogenic transforming growth factor tgf-β receptor complex tgf-β receptor signaling small-molecule kinase inhibitors
Questions {❓}
- On-target anti-TGF-β therapies are not succeeding in clinical cancer treatments: what are remaining challenges?
- Transforming growth factor β: tumor suppressor or promoter?
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