
PMC . NCBI . NLM . NIH . GOV {
}
Title:
M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer - PMC
Description:
The immunological microenvironment of primary high-grade serous carcinomas (HGSCs) has a major impact on disease outcome. Conversely, little is known on the microenvironment of metastatic HGSCs and its potential influence on patient survival. Here, ...
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27 years and 9 months (reg. 1997-10-02).
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Custom-built
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Keywords {๐}
cells, mtme, cancer, ptme, patients, tumor, doi, pubmed, google, scholar, study, figure, immune, group, tams, hgsc, mlike, metastatic, pmc, samples, article, primary, microenvironment, cell, ovarian, data, free, dclamp, functional, supplementary, prognostic, density, survival, paired, versus, analysis, table, macrophages, infiltration, determined, online, impact, compared, clinical, nkp, gene, pdl, expression, based, hgscs,
Topics {โ๏ธ}
muscle-invasive bladder cancer anti-ifn-ฮณ pe-cy7 project bbmri-cz lm2015089 high-grade serous carcinoma 10โยตg/ml anti-tim-3 antibodies p-tme versus m-tme m-tme versus p-tme web-based tool reactome pmc beta search 10โยตg/ml anti-pd-1 myeloid-derived suppressor cells pmc copyright notice tam-dependent cytokine signaling functional t-cell exhaustion long-term clinical outcome ifn-ฮณ+ cd3+cd8+ clinically relevant immunosupression p-tme-infiltrating counterparts cd8+ t-cell populations multivariate cox regression m-tme largely failed dual pd-1/tim-3 blockage multivariate cox regressions tumor-infiltrating mononuclear cells pd-1/pd-l1 axis cancer-immune set point m-tme-infiltrating cd8+ m-tme immune infiltrate chemotherapy-naive hgsc samples dc-lamp+ mature dcs robust m-tme infiltration m-tme including nkp46+ cd20+ tumor-infiltrating lymphocytes coinhibitory ligand pd-l1 m-tme dc-lamp phorbol 12-myristate13-acetate immune effector functions univariate cox analysis exhausted pd-1+tim-3+ cd8+ t-cell exhaustion p-tme versus identify molecular signatures m-tme influenced os lethal peritoneal cancers university hospital motol cell expressing cd163 ๏ฟฝ๏ฟฝ versus pd-l1+ underlie inhibited immunity +1โยตg/ml ionomycin cytotoxic effector granzyme
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