PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC7015061/.
Title:
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression - PMC
Description:
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) induces ferroptosis in cancer cells. Mechanistically, IR induces ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
Title:
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression - PMC
Description:
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) induces ferroptosis in cancer cells. Mechanistically, IR induces ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
Matching Content Categories {๐}
- Science
- Education
- Health & Fitness
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Custom-built
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Traffic Estimate {๐}
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๐ Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {๐}
ferroptosis, cancer, cell, cells, doi, fig, lipid, peroxidation, tumor, slca, acsl, expression, pubmed, irinduced, google, scholar, supplementary, information, treatment, pmc, article, staining, free, calculated, gpx, bars, values, means, fins, survival, exposure, error, independent, sulfasalazine, unpaired, students, ttest, radiotherapy, repeats, twotailed, response, radioresistance, ferrostatin, lines, data, hne, death, samples, radiation, induces,
Topics {โ๏ธ}
ros scavenger n-acetyl-l-cysteine 5โmm n-acetyl-l-cysteine long-chain fatty-acid-coenzyme cystine/glutamate transporter-deficient mice foxo-bnip3 axis exerts high-energy ionizing radiation apoptosis inhibitor z-vad-fmk keap1-mutant lung cancer glioma-induced brain edema unstable carbon-centered radicals keap1-mutant lung cancers tab patient-derived xenograft cold phosphate-buffered saline form fatty-acid radicals bar graph showing author contributions pmc beta search ir-induced h2ax phosphorylation equation volumeโ=โlengthโรโwidth2โรโ1/2 5โฮผm z-vad-fmk nod scid gamma ir-induced lipid peroxidation ir-induced dna damage ir-induced cell death xenograft tumors derived 4-hne mild/moderate group tsc-mtor signaling pathways ir-induced tumor suppression evidence-based clinical guidelines necroptosis inhibitor necrostatin-1s quantitative real-time pcr dampens ir-induced ferroptosis post-radiotherapy tumor samples mild/moderate 4-hne staining qrt-pcr qrt-pcr lncrna nbr2 engages anti-phospho-histone h2a converting pufa-pl-ooh ferroptosis inhibition-mediated radioresistance drives pufa-pl peroxidation pre-radiotherapy tumor samples slc7a11-mediated ferroptosis inhibition master transcription factor renal tumor growth generate acsl4 knockout significantly sensitizes tumors z-vad-fmk competing interests slc7a11-expressing h1299 cells inhibiting ir-induced ferroptosis
Questions {โ}
- Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
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