
PMC . NCBI . NLM . NIH . GOV {
}
Title:
TGF-β induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression - PMC
Description:
TGF-β/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we show that TGF-β ...
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27 years and 9 months (reg. 1997-10-02).
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Keywords {🔍}
cells, mirb, fig, supplementary, doi, tgfβ, pdac, cell, expression, data, mirna, mirnas, panc, pubmed, google, scholar, levels, cancer, analysis, pmc, article, transcripts, free, pancreatic, tumor, linb, genes, targets, leta, performed, mirhg, smad, significantly, clones, rnaseq, emt, lines, downregulated, enriched, control, overexpression, treated, shown, regulated, pathways, test, ish, response, stem, signaling,
Topics {✒️}
org/packages/release/bioc/html/deseq2 tgf-β-smads-signaling induces mir100hg primary multi-cistronic mirna-transcript author contributions crispr-cas9-mediated ko lines slight tgf-β-mediated decrease tgf-β/activin induce epithelial discussion tgf-β pmc beta search nodal/activin signaling drives cancer research airc/start anti-mir-125b significantly sensitized reduced disease-free survival mir-125b-target chimeras showed tgf-beta tumor suppression competing interests tgf-β-regulated factor ultra-low attachment plates ethanol/sodium acetate precipitation tgf-β-mediated response indicating avoid intra-tumoral heterogeneity additional tgf-β responsive parental wild-type cells chip-seq library preparation crispr-cas9 genome editing 20 mm tris-hcl ph7 panc-1 crispr-cas9 clones digital-cell imaging labs additional rna-binding proteins panc-1 tgf-β stables specific hrp-conjugated antibody tgf-β signaling components canonical/noncanonical-mediated repression wound-healing scratch assays redifect red-fluc-puromycin tgf-β induces mir-100 tgf-β treatment induced tgf-β cell responses super frost + glass slides mir-125b negatively affected tgf-β stable overexpression tgf-β-mediated tumourigenesis tgf-β activates smad2/3 footnotes publisher' mirna–target interactions inferred discovered mirna–target interactions tgf-β-mediated increase vivo tumor-initiating capacity tgf-β tumorigenesis assay tgf-β-induced tumourigenesis
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