
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Autonomous Extracellular Matrix Remodeling Controls a Progressive Adaptation in Muscle Stem Cell Regenerative Capacity during Development - PMC
Description:
Muscle stem cells (MuSCs) exhibit distinct behavior during successive phases of developmental myogenesis. However, how their transition to adulthood is regulated is poorly understood. Here, we show that fetal MuSCs resist progenitor specification ...
Website Age:
27 years and 9 months (reg. 1997-10-02).
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Keywords {π}
muscs, fetal, doi, cell, muscle, adult, cells, pubmed, google, scholar, musc, figure, stem, days, pmc, niche, article, transplantation, expression, satellite, repair, development, free, donor, mice, potential, figures, ecm, tnc, myofibers, tdtomato, collagen, pax, regenerative, growth, quantification, skeletal, levels, selfrenewal, isolated, myod, posttransplantation, regeneration, shown, performed, images, data, tissue, expressed, freshly,
Topics {βοΈ}
hind-limb-irradiated nod/scid mice donor-derived gfp+ myofibers nod/scid recipients confirmed donor-derived gfp+ cells time points post-ransplantation high-throughput cre reporting promoting tnf-mediated apoptosis supplemental experimental procedures tnf/p38Ξ±/polycomb signaling references bentzinger cf pmc beta search cusella-de angelis mg qrt-pcr analysis revealed pax7-positive satellite cells fluorescence-activated cell sorting musc time-lapse recording tissue-engineering strategies aimed supplementary materials included pax7-expressing satellite cells fluorescent-based cell sorting fifteen thousand pax7-creerβ’ fetal-derived paracrine factors tdtomato+ donor myofibers musc-mediated muscle repair 21 days post-transplantation freshly isolated pax7-creerβ’ gfp+ donor myofibers pax3/pax7-dependent population 3 days post-injury luciferase/egfp musc transplantation barium chloride suspended canonical wnt-signaling pathways Ξ±7-integrin expression defined hind limb muscle license information pmcid collagen vi assembly experimental procedures animals myogenic lineage progression 3 weeks post-transplantation stem cell pool satellite cell niche satellite cell transplantation tdtomato reporter gene hind limb muscles terminal myogenic differentiation inhibiting terminal differentiation regulatory factors underlie sousa-victor cell stem cell satellite cell expansion
Questions {β}
- Muscle satellite cells adopt divergent fates: a mechanism for self-renewal?
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