
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Oxidative stress inhibits distant metastasis by human melanoma cells - PMC
Description:
Solid cancer cells commonly enter the blood and disseminate systemically but are highly inefficient at forming distant metastases for poorly understood reasons. We studied human melanomas that differed in their metastasis histories in patients and ...
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27 years and 9 months (reg. 1997-10-02).
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Keywords {π}
cells, mice, melanoma, subcutaneous, tumours, doi, data, metastatic, figure, metastasis, melanomas, cancer, extended, scholar, pubmed, google, nodules, experiments, metastasizing, circulating, pmc, analysis, acid, cell, article, blood, patients, nsg, free, compared, significantly, table, independent, mitochondrial, oxidative, stress, distant, formed, mouse, nature, injection, folate, nadph, efficiently, flow, transplantation, pathway, experiment, test, injected,
Topics {βοΈ}
anti-oxidant n-acetyl-cysteine oncogene-expressing mammary acini lc-ms/ms metabolomics analysis cb17-prkdcscid il2rgtm1wjl/szj d-luciferin monopotassium salt polar-rp hplc column fusion-rp hplc column pmc beta search performed lc-ms/ms metabolomics pgipz mirna-based construct real-time imaging reveals parametric kruskal-wallis test 2g/kg body mass uniformly 13c-labelled glucose hif-dependent antitumorigenic effect mouse cd31/cd45/ter119 showed parametric mann-whitney test tumor-forming melanoma cells [u-13c]glucose mice nadph-regenerating enzyme aldh1l2 n-acetyl-cysteine anti-oxidant pathways circulating serine/glycine pools tumour-forming cells total nadph/nadp glo-assay produced de novo uniformly 13c-labelled small-cell lung cancer folate pathway inhibition lower gsh/gssg ratio mouse cd45/cd31/ter119 suggesting increased flux supplementary materials included cancer cell lines folate pathway showed [u-13c]glucose undergo additional metabolic nadph-regenerating enzyme folate pathway enzymes folate pathway involves interestβ measurement tools anti-oxidants inhibit serine synthesis pathway total replicates/treatment shown folate metabolism enzymes michigan medical school withstand oxidative stress oxidative stress management29β31 transient oxidative stress melanoma cells undergo
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