PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC4216740/.
Title:
Toll like receptor agonist imiquimod facilitates antigen-specific CD8+ T cell accumulation in the genital tract leading to tumor control through interferon-γ - PMC
Description:
Imiquimod is a toll-like receptor 7 agonist utilized topically to manage genital warts and basal cell carcinoma. We examine the combination of topical imiquimod with intramuscular administration of CRT/E7, a therapeutic HPV vaccination that ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Title:
Toll like receptor agonist imiquimod facilitates antigen-specific CD8+ T cell accumulation in the genital tract leading to tumor control through interferon-γ - PMC
Description:
Imiquimod is a toll-like receptor 7 agonist utilized topically to manage genital warts and basal cell carcinoma. We examine the combination of topical imiquimod with intramuscular administration of CRT/E7, a therapeutic HPV vaccination that ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Matching Content Categories {📚}
- Science
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Custom-built
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Traffic Estimate {📈}
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🌠 Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {🔍}
cells, imiquimod, doi, mice, hpv, google, scholar, cervicovaginal, tract, pubmed, vaccination, dna, treatment, pmc, cxcl, cancer, tumor, antigenspecific, cell, figure, article, especific, application, expression, vaginal, free, vaccine, local, therapeutic, tissue, immune, treated, genital, ifnγ, cxcr, accumulation, tlr, responses, compared, crte, antitumor, journal, number, pbs, tracts, significantly, effects, hung, clinical, generated,
Topics {✒️}
fc blocker anti-cd16/cd32 fitc-labeled anti-cd8a antibodies ifn-alpha-mediated antitumor reactivity anti-mouse fitc ifn-γ luciferase-expressing e7-specific cd8+ anti-mouse cd103 apc-mab induce immune-mediated rejection induce antigen-specific tissue-resident mucosal-homing e7-specific cd8+ cell-mediated immune responses hla-a2 transgenic mice h2-kb e7 tetramer therapeutic anti-lesion effects quantitative real-time pcr mesothelin-expressing ovarian cancer e7-expressing orthotopic tumors ifn-γ sense-acaatgaacgctacacactgcat dna prime-vaccinia boost β-actin sense-actgggacgacatggagaag tlr7-myd88-dependent signaling low-dose cyclophosphamide administered ifn-γ-secreting cd8+ dendritic cell-mediated induction detect ifn-γ secretion crt-e7 dna plasmid systemic e7-specific cd8+ β-actin housekeeping gene enhance site-specific immunity anti-mouse pe cd8 pmc beta search combining crt/e7 vaccination crt/e7 dna vaccine local e7-specific cd8+ mesothelin peptide-specific cd8+ ifn-γ receptor 1-deficient single dose enhances cxcr3/cd183 apc-mab induced mucosal-specific cd8+ antigen-expressing dendritic cells pngvl4a-crt-e7 vaccine tumor-specific immunity virus-derived antigen target antigen-specific cxcr3+ cd8+ intramuscular crt/e7 vaccination activated e7-specific cd8+ clin cancer res naked dna vector 40μg pngvl4a-crt-e7 potent immune response single-cell suspended splenocytes
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