
PMC . NCBI . NLM . NIH . GOV {
}
Title:
AXL mediates resistance to cetuximab therapy - PMC
Description:
The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired resistance to this agent is a common clinical problem. In this study we show that overexpression of the oncogenic receptor kinase AXL is sufficient to mediate ...
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27 years and 9 months (reg. 1997-10-02).
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Keywords {π}
axl, cetuximab, doi, egfr, cells, ctxr, resistance, cell, cancer, clones, figure, pubmed, google, scholar, expression, growth, activation, proliferation, signaling, pmc, tumors, acquired, resistant, mapk, article, data, treated, analysis, free, receptor, hnscc, tyrosine, sirna, increased, tumor, control, igg, antibody, role, treatment, pdxs, usa, mab, mrna, antiaxl, prior, kinase, overexpressed, factor, line,
Topics {βοΈ}
hrp-conjugated goat-anti-rabbit igg robust anti-proliferative responses robust anti-proliferative effects elicited anti-proliferative responses patient-derived tumor xenografts donkey-anti-goat igg bamh1/ecor1 restriction sites triple-negative breast cancers patient-derived xenografts established anti-axl monoclonal antibody pmc beta search ras/raf/mek/erk mapk/c-jun signaling pathway goat-anti-mouse igg small-cell lung cancer line taxane/carboplatin chemotherapy transcription factor c-jun early-stage colon cancer shown anti-tumorigenic effects hyperactivated mapk/c-jun signaling phospho axl-y779 antibody ctxr clones post-treatment ctxs cell line de novo models treat cetuximab-resistant cancers tumor xenograft assays squamous-cell carcinoma hp-axl stable cells united states government paxl-y779 expression levels gene expression profile anti-axl tki r428 small interfering rna receptor tyrosine kinases license information pmcid monoclonal antibody mab173 supplementary materials included single cell clones cetuximab-sensitive parental cells nih national center egfr-dependent ctxr cells researchers demonstrated axl ctxs parental cells growth inhibitory effects igg grew rapidly anti-axl antibody early passaged pdxs axl receptor played egfr kinase inhibitors positive feedback loop
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