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Keywords {🔍}

doi, pubmed, google, scholar, plant, mirnas, sirnas, arabidopsis, pmc, small, article, phasirnas, free, target, nblrrs, gene, genes, secondary, mirna, nucleotide, levels, loci, nblrr, tas, rnas, plants, rna, phased, families, regulation, function, zhai, biogenesis, family, cell, xia, tasirnas, targets, transcript, species, role, transcripts, proteins, silencing, hypothesis, regulatory, transacting, site, triggers, chen,

Topics {✒️}

dobzhansky-muller-type incompatibility syndrome trans-acting sirna-mediated repression double-stranded black/blue precursors nb-lrr–mirna interactions worth rna-dependent rna polymerases international brachypodium initiative nb-lrr–suppressive regulatory machinery rna-dependent rna polymerase rna-mediated chromatin-based silencing low-copy protein-coding genes nb-lrr-encoding genes snc1 nb-lrr–derived phased sirnas nb-lrr–encoding genes comprise numerous nb-lrr–targeting mirnas long-term evolutionary benefits pmc beta search mir173-programmed risc-cleaved rna nb-lrr-targeting mirna families additional nb-lrr–targeting mirnas directing ago1-dependent slicing rna-directed dna methylation trans-acting sirna formation r-gene-mediated resistance trans-acting sirna biogenesis modulates rps2-mediated resistance nbs-lrr-encoding genes plant nb-lrrs nb-lrrs nbs-encoding resistance genes increasing nb-lrr levels nb-lrr–mediated responses numerous protein-coding genes producing trans-acting sirnas nb-lrr transcript levels endogenous nb-lrr silencing van der biezen highly diversified nb-lrrs ��540 nb-lrr–coding genes rna-induced silencing complex nb-lrr levels triggered phased sirna-producing transcripts activating pamp-triggered immunity symmetrical stem-loop precursor transcripts encoding nb-lrrs small rna-based suppression pcr-based experimental approach protein-coding gene families mirna-mediated regulatory network house nitrogen-fixing rhizobia long-term benefits plant disease-resistance proteins

Questions {❓}

• , 2012), but is this indicative of greater redundancy of control for individual NB-LRRs or more specialization of targeting by individual miRNAs?
• Are the data consistent with this hypothesis?
• Could pNLs function in this interaction between genomes?
• If such a network exists, is it regulated dynamically in response to microbes?
• To return to the central question of this hypothesis: Are the data consistent with a hypothetical role in globally modulating plant defenses via suppression of NB-LRRs to promote beneficial microbial interactions?
• What is still missing from these studies to directly implicate miRNAs in the regulation of NB-LRR levels during defense responses?
• Yet after consideration of a variety of possibilities for the function of these small RNAs, we are left with a number of questions: (1) Why posttranscriptionally suppress NB-LRRs at all?

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