PMC . NCBI . NLM . NIH . GOV {
}
We are analyzing https://pmc.ncbi.nlm.nih.gov/articles/PMC3358904/.
Title:
Crystal structure of a Trypanosoma brucei metacaspase - PMC
Description:
Metacaspases are distantly related caspase-family cysteine peptidases implicated in programmed cell death in plants and lower eukaryotes. They differ significantly from caspases because they are calcium-activated, arginine-specific peptidases that ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Title:
Crystal structure of a Trypanosoma brucei metacaspase - PMC
Description:
Metacaspases are distantly related caspase-family cysteine peptidases implicated in programmed cell death in plants and lower eukaryotes. They differ significantly from caspases because they are calcium-activated, arginine-specific peptidases that ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
Matching Content Categories {π}
- Books & Literature
- Video & Online Content
- Education
Content Management System {π}
What CMS is pmc.ncbi.nlm.nih.gov built with?
Custom-built
No common CMS systems were detected on Pmc.ncbi.nlm.nih.gov, and no known web development framework was identified.
Traffic Estimate {π}
What is the average monthly size of pmc.ncbi.nlm.nih.gov audience?
π Phenomenal Traffic: 5M - 10M visitors per month
Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Pmc.ncbi.nlm.nih.gov Make Money? {πΈ}
We can't figure out the monetization strategy.
Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Pmc.ncbi.nlm.nih.gov could be getting rich in stealth mode, or the way it's monetizing isn't detectable.
Keywords {π}
doi, mca, pubmed, google, scholar, loop, structure, residues, fig, caspases, metacaspases, substrate, domain, nterminal, site, cell, caspase, pmc, article, active, activation, binding, catalytic, metacaspase, activity, free, death, Ξ²sheet, dyad, biol, crystal, protein, structural, pocket, terminus, calcium, shown, mcaca, cysteine, conserved, mcaac, structures, region, brucei, found, position, data, enzyme, mcacg, linker,
Topics {βοΈ}
peptide inhibitor z-vrpr-fmk inhibitor z-vrpr-fmk binds fluorogenic substrate z-ggr-amc arginine/lysine-specific cysteine proteases pmc beta search org/lookup/suppl/doi Ξ²-sheet/Ξ²-sheet dimerization found z-ggr-amc compared membrane-linked virulence factor n-terminal region remains mcii-pa metacaspase full-length recombinant enzyme n-terminal domain acting identify calcium-binding sites define calcium-binding sites caspase-independent cell death cysteine protease domain simple Ξ±/Ξ²-fold putative calcium-binding site cysteine protease zymogen z-ggr-amc wild-type human procathepsin supplementary materials included programmed cell death vibrio cholerae rtx unusual n-terminal domain n-terminal region reveals n-terminal region crossing n-terminal domain shown supporting information online core caspase/hemoglobinase fold arginine-specific substrate specificity predicted n-terminal prodomain peptide inhibitors bound fluorogenic peptide substrate calcium-induced loop movement arginine-specific peptidases poorer electron density license information pmcid cysteine peptidases found calcium-soaked crystals revealed cysteine peptidase domain cell cycle progression cell death pathways undergoes significant conformational n-terminal domain bloodstream form-specific rab11-positive endosomes aspartic acid residues mca2c213g-sm structure shows
Questions {β}
- Are metacaspases caspases?
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