
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Heterogeneity of Inflammatory and Cytokine Networks in Chronic Plaque Psoriasis - PMC
Description:
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response ...
Website Age:
27 years and 8 months (reg. 1997-10-02).
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- Education
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π Phenomenal Traffic: 5M - 10M visitors per month
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Keywords {π}
transcripts, expression, subjects, psoriasis, skin, signature, figure, inflammatory, patients, doi, figures, cytokine, cell, data, signatures, tif, respect, calculated, scholar, samples, google, based, lesional, patterns, risk, scores, pubmed, lesions, groups, strong, gene, ilweak, additional, identified, click, file, cells, weak, elevated, keratinocytes, significant, treatment, patient, moderate, subject, cytokineresponsive, versus, profiles, population, average,
Topics {βοΈ}
nk cell/activated t-cells blood-derived cd4+ t-cells pmc beta search immunohistochemical il-13rΞ±1 staining genome-wide expression profiles cytokine-encoding mrna levels genome-wide expression patterns th2-type cytokine produced pp-elevated/pp-decreased ratios wilcoxon rank-sum test intra-individual variation attributable fdr-corrected p-values raw p-values prior anti-tnf-alpha treatment risk allele frequency cd4+ t-cells relative helper t-cells/monocytes ige-mediated skin inflammation bone-marrow progenitor cells heightened cytokine-response patterns tnf-responsive transcripts elevated monoclonal antibody approved risk allele burden il-19-induced cytokine signature pp-decreased signature transcripts gene expression omnibus patient-specific genomic data assess inflammatory-cytokine relationships cytokine-responsive transcripts elevated body surface area genome-wide expression patient-specific inflammatory networks il-13-strong cytokine signatures pp-elevated transcripts varied il-13 mrna levels highly-ranked cell populations generate cytokine-response signatures pp-elevated signature transcripts/ cumulative risk score patient-specific transcriptome data pp-increased/pp-decreased expression level differences cytokine-responsive transcripts identified gene expression signatures activated t-cells οΏ½il-13-weakβ pattern identified sharply demarcated lesions il-13-weak cytokine group gene expression patterns publisher site pdf
Questions {β}
- How to individualize treatments?
- Type I interferon: potential therapeutic target for psoriasis?
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