
PMC . NCBI . NLM . NIH . GOV {
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Title:
Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption - PMC
Description:
Nuclear factor erythroid 2–related factor 2 (Nrf2) is a transcription factor that promotes the transcription of cytoprotective genes in response to oxidative and electrophilic stresses. Most functions of Nrf2 were identified by studying biological ...
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Keywords {🔍}
nrf, mice, doi, genes, gene, activation, pubmed, google, scholar, nrfnull, wildtype, nadph, keaphko, expression, keapkd, analysis, pmc, involved, doseresponse, induced, liver, pathway, stress, mrna, article, oxidative, model, protein, fig, free, keap, gsh, higher, study, acid, lower, data, mouse, transcription, glutathione, lipid, suppressed, role, target, increased, fatty, livers, hepatic, yamamoto, metabolism,
Topics {✒️}
clara-cell-specific keap1-ko mice high-performance liquid chromatography high-fat diet-induced obesity gene dose-response approach synthetic triterpenoid cddo-imidazolide real-time pcr analysis hepatocyte-specific keap1-null mouse formaldehyde-agarose gel electrophoresis �gene dose-response” model gene dose-response model pmc beta search nrf2-mediated adaptive response cul3-based e3 ligase tata-box binding protein cddo-im activates smad keap1-null mutation leads differentiation-induced gene expression uplc-ms/ms analysis uplc-ms-ms analysis free intracellular concentration high-fat diet related stress responses keap1-null mice died acetaminophen-induced liver injury oxidative stress-induced toxicity prevents uncontrolled surges pathway-specific gene expression wild-type mice found primary nrf2-dependent pathways supplementary materials included anit-induced cholestasis free ion storage keap1-hepatocyte knockout mouse stearoyl-coa desaturase crossing keap1-kd mice acute drug toxicity reverse-phase hplc column nrf2-null mice tended wild-type mice showed canonical pathway–cased analysis negative regulatory system albumin-cre loxp system keap1-hko mouse increase nrf2-null mice showed reactive oxygen species publisher site pdf constitutive androstane receptor oligonucleotide primers specific 1093/toxsci/kfr183 beneficial role mutant sod1 alters
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