
PMC . NCBI . NLM . NIH . GOV {
}
Title:
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor - PMC
Description:
Nur77 is a nuclear orphan steroid receptor that has been implicated in negative selection. Expression of Nur77 in thymocytes and cell lines leads to apoptosis through a mechanism that remains unclear. In some cell lines, Nur77 was reported to act ...
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27 years and 9 months (reg. 1997-10-02).
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Keywords {🔍}
ndg, apoptosis, thymocytes, transgenic, cells, mice, doi, pubmed, google, scholar, caspase, expression, cell, bcl, genes, figure, protein, activation, analysis, apoptotic, pmc, data, death, levels, receptor, article, negative, microarray, selection, free, nurmediated, shown, antibodies, control, sequences, cytochrome, downstream, fold, αcd, upregulated, tcell, animals, transcription, thymocyte, transfected, trail, pathway, role, activity, caspases,
Topics {✒️}
tricolor-conjugated α-cd8 antibody nur77/n10-transgenic thymocytes involves conserved c-terminal cysteines c-terminal flag tag cell-permeable fluorogenic substrates t-cell receptor ligation ucb/ucsf custom microarray pmc beta search ucb/ucsf cdna microarray quantitative rt–pcr analysis 1093/emboj/cdg620 transcriptional activation t-cell tolerance quantitative rt–pcr analyses full-length cdna sequences c-terminal truncation mutants major histocompatibility complex-restricted nur77-regulated enhancers located rt–pcr data corroborate full-length dna sequences peptide/mhc induces activation fas/fas ligand pathway central gxxxgh motif treated with1 µm dexamethasone cell receptor-induced proliferation cd4+cd8+ double-positive f5-tcr transgenic mice cotransfected full-length caspase-3 antagonize nur77-mediated apoptosis ice-cold dounce homogenizer full-length variants t-cell activation ctla-4 antigen-induced negative selection ncbi web site nur77-mediated cell death lck proximal promoter proximal lck promoter cd4+cd8+7aad+ population caspase-3-dependent cell death f5-tcr transgenic animals quantitative rt–pcr rescue nur77-mediated death involves transcriptional activation dominant-negative nur77 protein β-actin control antibody gfp-positive gfp cells t-cell receptor full-length species cytochrome-c-specific antibodies ndg1/bcl-2 transgenic mice α-fas-treated cells
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