
PMC . NCBI . NLM . NIH . GOV {
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Title:
An Intralysosomal hsp70 Is Required for a Selective Pathway of Lysosomal Protein Degradation - PMC
Description:
Previous studies have implicated the heat shock cognate (hsc) protein of 73 kD (hsc73) in stimulating a lysosomal pathway of proteolysis that is selective for particular cytosolic proteins. This pathway is activated by serum deprivation in confluent ...
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Keywords {🔍}
doi, mab, hsc, protein, proteins, lysosomes, pubmed, lysosomal, google, scholar, lyhsc, fig, degradation, cell, cells, biol, dice, pathway, fibroblasts, pmc, serum, cytosolic, hsp, heat, article, endocytosed, shock, free, proteolysis, purified, terlecky, incubated, ncs, substrate, cuervo, membrane, pbp, lane, rnase, shown, μgml, lgp, trypsin, medium, antibodies, times, endocytosis, overnight, media, selective,
Topics {✒️}
lys-phe-glu-arg-gln pmc beta search pmc copyright notice 25 μci/ml [3h]l-leucine heat-shock cognate protein mammalian glucose-regulated protein x-omat ar film pta/hcl-precipitable radioactivity represents mixed ly-hsc73 major heat-inducible hsp70 publisher site pdf serum-supplemented nonconfluent cells 35s-labeled cytosolic proteins 70-kd heat-shock proteins heat shock cognate pta/hcl-soluble radioactivity serum/amino acid deprivation bovine brain cytosol license information pmcid heat shock protein serum-supplemented culture medium o'farrell [35s]l-methionine lysosomes contained ly-hsc73 cold spring harbor pmc disclaimer heat shock proteins peptide sequences related acid-soluble radioactivity thick optical section eightfold molar excess glucose-responsive genes black rectangle represents mouse spermatogenic cells amino acid sequence region gene segments igm recognizes α-1 fluid-phase marker endocytosis completely blocks endocytosed hrp released senescent human fibroblasts completely digest hsc73 united states government glyceraldehyde-3phosphate dehydrogenase glyceraldehyde-3-phosphate dehydrogenase maine biotechnology services jackson immunoresearch laboratories bio rad laboratories fluorescent double labeling external radioactive standard
Questions {❓}
- Can Hsp70 proteins act as force-generating motors?
- What drives the translocation of proteins?
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