
PMC . NCBI . NLM . NIH . GOV {
}
Title:
The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy - PMC
Description:
In response to lysosomal damage, cells engage several quality-control mechanisms, including the selective isolation and degradation of damaged lysosomes by lysophagy. Here, we report that the selective autophagy adaptor SQSTM1/p62 is recruited to ...
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Keywords {🔍}
cells, hsp, cat, cell, doi, google, scholar, pubmed, lysosomes, hela, llome, lysosomal, lysophagy, damaged, pmc, article, free, figures, experiments, autophagy, puncta, quantification, neurons, damage, lot, sirna, rrid, observed, condensates, protein, recruitment, area, figure, intensity, condition, test, number, treatment, egfpp, control, egfphsp, domain, treated, selective, images, abcam, autophagosome, endogenous, representative, transfected,
Topics {✒️}
pflag-cmv2-hsp27-s15a/s78a/s82a pflag-cmv2-hsp27-s15d/s78d/s82d p62-si+wt/p62-si+lirmut sheep polyclonal anti-lamp1/cd107a axonal charcot-marie-tooth disease 5 mg/ml poly-l-lysine mouse monoclonal anti-ha-tag goat anti-mouse igg p62-si+wt/p62-si+mcherry control-si+mcherry/p62-si+mcherry control-si+mcherry/p62-si+wt atg8-family proteins gabarap/l1/l2 egfp-s15a/s78a/s82a hsp27 p62-si+wt/p62-si+δpb1 p62-si+wt/p62-si+δuba rabbit anti-α/β-tubulin identifier antibodies ο/β-tubulin egfp-s15d/s78d/s82d hsp27 p0781 poly-l-lysine halotag-lc3 pulse-chase assay p1274 poly-l-ornithine rabbit monoclonal anti-gabarap chicken polyclonal anti-mcherry chicken polyclonal anti-gfp rabbit monoclonal anti-tau rabbit polyclonal anti-galectin-8 phase-separated protein droplets rabbit polyclonal anti-fip200 mouse monoclonal anti-tau rabbit polyclonal anti-lamp1 rabbit polyclonal anti-lc3b rabbit polyclonal anti-optn rabbit polyclonal anti-halotag rabbit monoclonal anti-hsp90 mouse monoclonal anti-galectin-3 rabbit polyclonal anti-ndp52 mouse monoclonal anti-hsp27 rabbit anti-pser78 hsp27 mouse monoclonal anti-gfp mouse monoclonal anti-p62 poly-l-ornithine overnight rabbit monoclonal anti-tax1bp1 parkin-induced mitochondrial clustering liquid-phase separated condensates 49na oil-immersion objective 40na oil-immersion objective ab_2798306 gabarap/l1/l2 anti-ha magnetic beads 3x-phospho-mimetic mutant α-gabarap band intensities
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