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Title:
Porous hydroxyapatite carrier enables localized and sustained delivery of honokiol for glioma treatment - ScienceDirect
Description:
The objective of this study is to develop hydroxyapatite (HAp) particles for targeted delivery of honokiol to tumor sites after glioma surgical manageβ¦
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Keywords {π}
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Topics {βοΈ}
aptamer-functionalized peg-plga nanoparticles section snippets materials download high-res image chi-shun chiang laboratory inducing mitochondria-dependent apoptosis triple-negative breast cancer local long-term delivery tumor-treating fields world long-acting antidepression treatment anti-glioma chemotherapeutic agents open access content averages approximately 5Β mg/kg discover nano view graphical abstract download hydroxyapatite-based materials drug-carrier system protein powder suspensions hap-honokiol treatment shows high-grade gliomas long-term survival central nervous system drug loading capacity line chemotherapeutic agent form hap-honokiol particles possesses anti-oxidation create porous structures drug delivery carriers anti-depression effects locally release drugs kuo-chi chang compromising drug efficacy exhibits neuroprotective properties experimental malignant gliomas cancer cell uptake low drug penetration mesoporous hydroxyapatite high-dosage drugs yu-chen hsu neutral environments due apoptosis pathway induced surgical management remains bulky size limits achieving efficacious concentrations micro-particle form traditional simple diffusion organometallic tamoxifen derivative stand south asian inflammation-mediated pharmacokinetics cancer cells remaining kill cancer cells
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