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Title:
Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells - ScienceDirect
Description:
Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases. …
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Keywords {🔍}
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Topics {✒️}
single ultra-low doses long half-lives owing long-lived il-2 correlates il-2 fusion proteins autoimmune disease indications treg-specific epigenetic signatures recommended articles long half-lives open access content tregs abstract regulatory engineered il-2 molecules multiple-dose proleukin pleiotropic cytokine increasing treg specificity reduced treg function anne freimoser-grundschober common autoimmune diseases subsequent sustained increases suprathreshold pstat5a induction greatly expand tregs common pleiotropic effects treg expansion autoimmunity volume 56 issue articles found authors contributed equally il-2 pathway cells treg induction prolonged state regulatory increases tregs autoimmunity fusion increases affinity contributed equally support terms search pages 66-80 sustained increasingly sustained il-2 lower doses vivo effects main contentskip account sign yongliang sun jan clark sarah howlett xin yang oliver ast
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