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Title:
IMGTÂź Tools for the Nucleotide Analysis of Immunoglobulin (IG) and T Cell Receptor (TR) V-(D)-J Repertoires, Polymorphisms, and IG Mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS | SpringerLink
Description:
IMGT/V-QUEST is the highly customized and integrated online IMGT® tool for the standardized analysis of the immunoglobulin (IG) or antibody and T cell receptor (TR) rearranged nucleotide sequences. The analysis of these antigen receptors represents a crucial...
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Keywords {đ}
lefranc, google, scholar, imgt, article, pubmed, cas, analysis, giudicelli, cell, immunoglobulin, immunogenetics, receptor, information, imgtvquest, duroux, system, sequences, gene, chapter, nucleic, acids, res, montpellier, protocol, vdj, standardized, imgthighvquest, tool, antibody, receptors, genes, chaume, international, kaas, nomenclature, privacy, cookies, content, data, publish, tools, nucleotide, online, access, sequence, immunology, eds, imgtontology, database,
Topics {âïž}
imgt/v-quest integrates imgt/junctionanalysis antigen receptors-high-throughput version month download article/chapter standardized sequence-structure representations formal imgt-ontology paradigm imgt/v-quest identifies marie-paule lefranc colliers de perles imgtÂź home page high-throughput version privacy choices/manage cookies nova science publishers yousfi-monod imgt/highv-quest high-throughput system national transplant services device instant download rio de janeiro antigen receptors represents v-region mutations imgt/v-quest 13th international congress ighv gene insertions imgt unique numbering wolters kluwer health author information authors editor information editors cell receptors report imgt standardized criteria gene-centered information imgtÂź immunoinformatics tools adaptive immune response disease-related situations imgt reference directory hot spot positions integrated software program imgt/3dstructure-db imgt/structural query imgtÂź received funding rĂ©gion languedoc-roussillon cell receptor v immunogenetics sequence annotation imgt/gene-db imgt gene identification journal finder publish conditions privacy policy tr standardized v imgtÂź Âstandardized analysis chronic lymphocytic leukemia royal melbourne hospital
Questions {â}
- Kaas Q, Ehrenmann F, Lefranc M-P (2007) IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?
Schema {đșïž}
ScholarlyArticle:
headline:IMGTÂź Tools for the Nucleotide Analysis of Immunoglobulin (IG) and T Cell Receptor (TR) V-(D)-J Repertoires, Polymorphisms, and IG Mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS
pageEnd:604
pageStart:569
image:https://media.springernature.com/w153/springer-static/cover/book/978-1-61779-842-9.jpg
genre:
Springer Protocols
isPartOf:
name:Immunogenetics
isbn:
978-1-61779-842-9
978-1-61779-841-2
type:Book
publisher:
name:Humana Press
logo:
url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
type:ImageObject
type:Organization
author:
name:Eltaf Alamyar
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, the International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
type:Person
name:Patrice Duroux
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
type:Person
name:Marie-Paule Lefranc
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142, Montpellier, France
type:PostalAddress
type:Organization
email:[email protected]
type:Person
name:Véronique Giudicelli
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
type:Person
keywords:IMGT, Immunogenetics, Immunoinformatics, Immunoglobulin, Antibody, T cell receptor, Somatic hypermutation, Allelic polymorphism, High-throughput sequencing, IMGT-ONTOLOGY
description:IMGT/V-QUEST is the highly customized and integrated online IMGTÂź tool for the standardized analysis of the immunoglobulin (IG) or antibody and T cell receptor (TR) rearranged nucleotide sequences. The analysis of these antigen receptors represents a crucial challenge for the study of the adaptive immune response in normal and disease-related situations. The expressed IG and TR repertoires represent a potential of 1012 IG and 1012 TR per individual. This huge diversity results from mechanisms that occur at the DNA level during the IG and TR molecular synthesis. These mechanisms include the combinatorial rearrangements of the variable (V), diversity (D) and joining (J) genes, the N-diversity (deletion and addition at random of nucleotides during the V-(D)-J rearrangement) and, for IG, somatic hypermutations. IMGT/V-QUEST identifies the V, D, J genes and alleles by alignment with the germline IG and TR gene and allele sequences of the IMGT reference directory. The tool describes the V-REGION mutations and identifies the hot spot positions in the closest germline V gene. IMGT/V-QUEST integrates IMGT/JunctionAnalysis for a detailed analysis of the V-J and V-D-J junctions and IMGT/Automat for a complete annotation of the sequences and also provides IMGT Collier de Perles. IMGT/HighV-QUEST, the high-throughput version of IMGT/V-QUEST, implemented to answer the needs of deep sequencing data analysis from Next Generation Sequencing (NGS), allows the analysis of thousands of IG and TR sequences in a single run. IMGT/V-QUEST and IMGT/HighV-QUEST are available at the IMGTÂź Home page,
http://www.imgt.org
.
datePublished:2012
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Book:
name:Immunogenetics
isbn:
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978-1-61779-841-2
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name:Humana Press
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address:
name:IMGTÂź, the International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
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address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
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address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142, Montpellier, France
type:PostalAddress
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
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name:Eltaf Alamyar
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, the International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
name:Patrice Duroux
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
name:Marie-Paule Lefranc
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142, Montpellier, France
type:PostalAddress
type:Organization
email:[email protected]
name:Véronique Giudicelli
affiliation:
name:UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142
address:
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
type:PostalAddress
type:Organization
PostalAddress:
name:IMGTÂź, the International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS1142, Montpellier, France
name:IMGTÂź, The International ImMunoGeneTics Information SystemÂź, UniversitĂ© Montpellier 2, Laboratoire dâImmunoGĂ©nĂ©tique MolĂ©culaire (LIGM), Institut de GĂ©nĂ©tique Humaine (IGH), UPR CNRS 1142, Montpellier, France
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