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Title:
NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds | SpringerLink
Description:
G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human...
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Balasubramanian S, Hurley LH, Neidle S (2011) Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

Schema {🗺️}

ScholarlyArticle:
      headline:NMR Studies of G-Quadruplex Structures and G-Quadruplex-Interactive Compounds
      pageEnd:176
      pageStart:157
      image:https://media.springernature.com/w153/springer-static/cover/book/978-1-4939-9666-7.jpg
      genre:
         Springer Protocols
      isPartOf:
         name:G-Quadruplex Nucleic Acids
         isbn:
            978-1-4939-9666-7
            978-1-4939-9665-0
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         name:Springer New York
         logo:
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      author:
            name:Clement Lin
            affiliation:
                  name:Purdue University
                  address:
                     name:Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jonathan Dickerhoff
            affiliation:
                  name:Purdue University
                  address:
                     name:Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Danzhou Yang
            affiliation:
                  name:College of Pharmacy, Purdue University
                  address:
                     name:Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
                  name:Purdue Center for Cancer Research
                  address:
                     name:Purdue Center for Cancer Research, West Lafayette, USA
                     type:PostalAddress
                  type:Organization
                  name:Purdue Institute for Drug Discovery
                  address:
                     name:Purdue Institute for Drug Discovery, West Lafayette, USA
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            email:[email protected]
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      keywords:NMR spectroscopy, G-quadruplex structures, G-quadruplex-interactive compounds
      description:G-quadruplexes are noncanonical, four-stranded nucleic acid secondary structures formed in sequences containing consecutive runs of guanines. These G-quadruplex structures have been found to form in nucleic acid regions of biological significance, including human telomeres, gene promoters, and untranslated regions of mRNA. Thus, they are considered attractive therapeutic targets. Nuclear magnetic resonance (NMR) spectroscopy is a powerful method for understanding the structures of G-quadruplexes and their interactions with small molecules under physiologically relevant conditions. Here, we present the NMR methodology used in our research group for the study of DNA G-quadruplex structures in physiologically relevant solution and their ligand interactions.
      datePublished:2019
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               type:PostalAddress
            type:Organization
      name:Jonathan Dickerhoff
      affiliation:
            name:Purdue University
            address:
               name:Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
               type:PostalAddress
            type:Organization
      name:Danzhou Yang
      affiliation:
            name:College of Pharmacy, Purdue University
            address:
               name:Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
               type:PostalAddress
            type:Organization
            name:Purdue Center for Cancer Research
            address:
               name:Purdue Center for Cancer Research, West Lafayette, USA
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               name:Purdue Institute for Drug Discovery, West Lafayette, USA
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      name:Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
      name:Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
      name:Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, USA
      name:Purdue Center for Cancer Research, West Lafayette, USA
      name:Purdue Institute for Drug Discovery, West Lafayette, USA
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